Convenient Preparation of Original Vinylic Chlorides with Antiparasitic Potential in Quinoline Series

Pierre      Verhaeghe; Pascal      Rathelot; Sylvain      Rault; Patrice      Vanelle

doi:10.2174/157017806779467997

Abstract

The synthesis of various original vinylic chlorides from trichloromethylated substrates in the quinoline series is described herein. This reaction takes place under mild operating conditions via a monoelectronic transfer mechanism and presents elevated yields.

Keywords: Quinoline, antiparasitic drugs, SRN1, ERC1, vinylic chloride

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Letters in Organic Chemistry

Title: Convenient Preparation of Original Vinylic Chlorides with Antiparasitic Potential in Quinoline Series

Volume: 3 Issue: 12

Author(s): Pierre Verhaeghe, Pascal Rathelot, Sylvain Rault and Patrice Vanelle

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Keywords: Quinoline, antiparasitic drugs, SRN1, ERC1, vinylic chloride

Abstract: The synthesis of various original vinylic chlorides from trichloromethylated substrates in the quinoline series is described herein. This reaction takes place under mild operating conditions via a monoelectronic transfer mechanism and presents elevated yields.

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Verhaeghe Pierre, Rathelot Pascal, Rault Sylvain and Vanelle Patrice, Convenient Preparation of Original Vinylic Chlorides with Antiparasitic Potential in Quinoline Series, Letters in Organic Chemistry 2006; 3 (12) . https://dx.doi.org/10.2174/157017806779467997