A Facile One-Pot Synthesis of New Spiro Pyrrolidine-Oxindoles Under Ultrasonic Irradiation in DMSO-H2O

Javad      Azizian; Ali      Saffar-Teluri; Ali      Asadi

doi:10.2174/157017806779468068

Abstract

Ultrasonic irradiation effectively promotes the 1,3-dipolar cycloaddition reaction of azomethine ylides generated from L-phenyl alanine and isatin derivatives via the decarboxylative with N-aryl maleimides in aqueous solution under stereoselective cycloaddition via endo-transition state to give new spiro pyrrolidine cycloadducts.

Keywords: Ultrasonic, 1,3-dipolar cycloaddition, spiro pyrolidines, azomethine ylides, stereoselective, endo-transition state

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Letters in Organic Chemistry

Title: A Facile One-Pot Synthesis of New Spiro Pyrrolidine-Oxindoles Under Ultrasonic Irradiation in DMSO-H2O

Volume: 3 Issue: 12

Author(s): Javad Azizian, Ali Saffar-Teluri and Ali Asadi

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Keywords: Ultrasonic, 1,3-dipolar cycloaddition, spiro pyrolidines, azomethine ylides, stereoselective, endo-transition state

Abstract: Ultrasonic irradiation effectively promotes the 1,3-dipolar cycloaddition reaction of azomethine ylides generated from L-phenyl alanine and isatin derivatives via the decarboxylative with N-aryl maleimides in aqueous solution under stereoselective cycloaddition via endo-transition state to give new spiro pyrrolidine cycloadducts.

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Azizian Javad, Saffar-Teluri Ali and Asadi Ali, A Facile One-Pot Synthesis of New Spiro Pyrrolidine-Oxindoles Under Ultrasonic Irradiation in DMSO-H2O, Letters in Organic Chemistry 2006; 3 (12) . https://dx.doi.org/10.2174/157017806779468068