Hypothalamic Neuropeptide Systems as Targets for Potential Anti-Obesity Drugs

E.      Dozio; M.      Ruscica; M.      Motta; P.      Magni

doi:10.2174/138955707779317894

Abstract

Food intake and energy homeostasis are controlled by peripheral humoral signals, afferent neuronal pathways to the brain and central signals, represented, in particular, by neuropeptides. This review reports the status of development of novel compounds targeting some hypothalamic neuropeptide systems which are currently viewed as potential targets to treat obesity.

Keywords: NPY, AgRP, MCH, orexins, galanin, POMC, CART, CRH