Abstract
Lamotrigine (LTG) is a modern, effective and well-tolerated antiepileptic drug (AED) with an expected low teratogenic potential and therefore regarded as a relative safe drug for women of reproductive age. Recent studies, however, have demonstrated that co-administration of LTG and combined oral contraceptives (OCs) and pregnancy interfere with the metabolism of LTG with the risk of therapeutic failure. It is therefore recommended that plasma level of LTG should be closely monitored before and after introduction or discontinuation of OCs and monthly during pregnancy.
Keywords: Lamotrigine, pharmacokinetics, anticonception, pregnancy, interaction
Letters in Drug Design & Discovery
Title: Lamotrigine Pharmacokinetics During Anticonception and Pregnancy
Volume: 3 Issue: 5
Author(s): A. Sabers
Affiliation:
Keywords: Lamotrigine, pharmacokinetics, anticonception, pregnancy, interaction
Abstract: Lamotrigine (LTG) is a modern, effective and well-tolerated antiepileptic drug (AED) with an expected low teratogenic potential and therefore regarded as a relative safe drug for women of reproductive age. Recent studies, however, have demonstrated that co-administration of LTG and combined oral contraceptives (OCs) and pregnancy interfere with the metabolism of LTG with the risk of therapeutic failure. It is therefore recommended that plasma level of LTG should be closely monitored before and after introduction or discontinuation of OCs and monthly during pregnancy.
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Sabers A., Lamotrigine Pharmacokinetics During Anticonception and Pregnancy, Letters in Drug Design & Discovery 2006; 3 (5) . https://dx.doi.org/10.2174/157018006777574267
DOI https://dx.doi.org/10.2174/157018006777574267 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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