Convergent Synthetic Studies Towards the Ribosyl-Diazepanone Core of the Liposidomycins

Christine      Greck; Bruno      Drouillat; Yann      Bourdreux

doi:10.2174/157017806776611827

Abstract

New types of ribosyl-diazepanone derivatives of nucleoside antibiotic liposidomycins, 12a and 12b, have been synthesised. The ribosyl 7-membered heterocycles were formed by reductive amination of the α-ribosylamino acid 9 derived from D-ribose and the amino aldehydes 10a or 10b, followed by a peptidic coupling reaction.

Keywords: ribosylamino acid, liposidomycin, lactamisation, diazepanone, Antibiotic

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Letters in Organic Chemistry

Title: Convergent Synthetic Studies Towards the Ribosyl-Diazepanone Core of the Liposidomycins

Volume: 3 Issue: 5

Author(s): Christine Greck, Bruno Drouillat and Yann Bourdreux

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Keywords: ribosylamino acid, liposidomycin, lactamisation, diazepanone, Antibiotic

Abstract: New types of ribosyl-diazepanone derivatives of nucleoside antibiotic liposidomycins, 12a and 12b, have been synthesised. The ribosyl 7-membered heterocycles were formed by reductive amination of the α-ribosylamino acid 9 derived from D-ribose and the amino aldehydes 10a or 10b, followed by a peptidic coupling reaction.

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Greck Christine, Drouillat Bruno and Bourdreux Yann, Convergent Synthetic Studies Towards the Ribosyl-Diazepanone Core of the Liposidomycins, Letters in Organic Chemistry 2006; 3 (5) . https://dx.doi.org/10.2174/157017806776611827