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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis of C7-Substituted Estra-1,3,5(10),6-Tetraen-3,17 β-Diols

Author(s): Thies Thiemann, G. Ribeiro M. and Maria C. d. Neves Oliveira

Volume 3, Issue 3, 2006

Page: [214 - 219] Pages: 6

DOI: 10.2174/157017806775789796

Price: $65

Abstract

A series of C7-substituted estra-1,3,5(10),6-tetraene-3,17β-diols were prepared as precursors to radiodiagnostic agents of breast cancer. The introduction of the olefin moiety at C6/C7 in the molecules was achieved through thermal elimination of the 6-hydroxy group in the corresponding estra-1,3,5(10)-triene- 3,17β-diols.

Keywords: thermal dehydration, conjugate addition, steroids, Estranes


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