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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

HIV-1 RNase H: Recent Progress in an Exciting, yet Little Explored, Drug Target

Author(s): Enzo Tramontano

Volume 6, Issue 6, 2006

Page: [727 - 737] Pages: 11

DOI: 10.2174/138955706777435733

Price: $65

Abstract

HIV-1 reverse transcriptase-associated ribonuclease H (RNase H) is an attractive non traditional target for drug development which has been, so far, little explored. All drugs shown to inhibit HIV-1 RNase H are reported, including the recently described classes of compounds that interact with the metal ions in the active site.

Keywords: HIV-1, Reverse transcriptase, Ribonuclease H, Inhibition, Drug development, N-hydroxyimides, Diketo acids

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