Synthesis and Antinociceptive Behaviors of New Methyl and Hydroxyl Derivatives of Phencyclidine

Title: Synthesis and Antinociceptive Behaviors of New Methyl and Hydroxyl Derivatives of Phencyclidine

Volume: 19 Issue: 5

Author(s): A. Ahmadi, M. Kermani, N. Naderi, R. Hajikhani, N.M. Rezaee, M. Javadi and B.N. Niknafs

Affiliation:

Keywords: Antinociceptive behaviors, Formalin test, Phencyclidine, Writhing test, pharmacological behaviors, analgesic, anti-anxiety, anticonsulvant, analgesic effects

Abstract: Phencyclidine (I) and its derivatives show such pharmacological behaviors as analgesic, anticonsulvant, anti-anxiety and antidepressant, while interacting with central nervous system. In this study, new methyl and hydroxyl derivatives of PCP were synthesized and their antinociceptive behaviors in animals were examined by measuring the number of writhing in a writhing test of visceral pain and the pain scores in Formalin test. Compared to control and PCP groups, findings in experimental groups indicated the new synthesized analogues (compounds II, III and V, 10 mg/kg) of PCP were able to produce more analgesic effects in formalin and writhing tests, especially for compound V. It was concluded that the new synthesized derivatives of PCP could substantially and respectively diminish acute and chronic pains.

Cite this article as:

Ahmadi A., Kermani M., Naderi N., Hajikhani R., Rezaee N.M., Javadi M. and Niknafs B.N., Synthesis and Antinociceptive Behaviors of New Methyl and Hydroxyl Derivatives of Phencyclidine, Current Medicinal Chemistry 2012; 19 (5) . https://dx.doi.org/10.2174/092986712798992057