Abstract
Traditionally, nutrients such as fatty acids have been viewed as substrates for the generation of high-energy molecules and as precursors for the biosynthesis of macromolecules. However, accumulating data from multiple lines of evidence suggest that dietary fatty acids are linked not only to health promotion but also to disease pathogenesis. Metabolism in humans is regulated by complex hormonal signals and substrate interactions. For many years, the clinical focus has centered on a wide metabolic picture after an overnight fast. Nonetheless, the postprandial state (i.e., “the period that comprises and follows a meal”) is an important one, and silent disturbances in this period are involved in the genesis of numerous pathological conditions, including atherosclerosis. In this review article, we present an overview of the evidence demonstrating the relevance of oleic acid in olive oil on different nutritionrelated issues. We also discuss the impact of oleic acid in olive oil and its clinical relevance to major risk factors for cardiovascular disease in the context of the postprandial state and with regard to other dietary fatty acids.
Keywords: Oleic acid, olive oil, postprandial state, cardiovascular risk factors, biosynthesis, pathogenesis, esterified, ingestion, stereochemical, Lampante, arachidic acid, behenic acid, Gastric lipase, duodenal, cholecystokinin, stereospecific, eicosapentaenoyl, reacylation, basolateral
Current Pharmaceutical Design
Title: Oleic Acid in Olive Oil: From a Metabolic Framework Toward a Clinical Perspective
Volume: 17 Issue: 8
Author(s): Beatriz Bermudez, Sergio Lopez, Almudena Ortega, Lourdes M. Varela, Yolanda M. Pacheco, Rocio Abia and Francisco J.G. Muriana
Affiliation:
Keywords: Oleic acid, olive oil, postprandial state, cardiovascular risk factors, biosynthesis, pathogenesis, esterified, ingestion, stereochemical, Lampante, arachidic acid, behenic acid, Gastric lipase, duodenal, cholecystokinin, stereospecific, eicosapentaenoyl, reacylation, basolateral
Abstract: Traditionally, nutrients such as fatty acids have been viewed as substrates for the generation of high-energy molecules and as precursors for the biosynthesis of macromolecules. However, accumulating data from multiple lines of evidence suggest that dietary fatty acids are linked not only to health promotion but also to disease pathogenesis. Metabolism in humans is regulated by complex hormonal signals and substrate interactions. For many years, the clinical focus has centered on a wide metabolic picture after an overnight fast. Nonetheless, the postprandial state (i.e., “the period that comprises and follows a meal”) is an important one, and silent disturbances in this period are involved in the genesis of numerous pathological conditions, including atherosclerosis. In this review article, we present an overview of the evidence demonstrating the relevance of oleic acid in olive oil on different nutritionrelated issues. We also discuss the impact of oleic acid in olive oil and its clinical relevance to major risk factors for cardiovascular disease in the context of the postprandial state and with regard to other dietary fatty acids.
Export Options
About this article
Cite this article as:
Bermudez Beatriz, Lopez Sergio, Ortega Almudena, M. Varela Lourdes, M. Pacheco Yolanda, Abia Rocio and J.G. Muriana Francisco, Oleic Acid in Olive Oil: From a Metabolic Framework Toward a Clinical Perspective, Current Pharmaceutical Design 2011; 17 (8) . https://dx.doi.org/10.2174/138161211795428957
DOI https://dx.doi.org/10.2174/138161211795428957 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Do We Need More Research on Platelet Function in South Asian Immigrants?
Inflammation & Allergy - Drug Targets (Discontinued) The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders
Current Topics in Medicinal Chemistry Prevalence, Incidence, Risk and Protective Factors of Amnestic Mild Cognitive Impairment in the Elderly in Shanghai
Current Alzheimer Research Biomarkers for Risk Assessment and Prevention of Breast Cancer
Current Cancer Drug Targets Current Applications of Therapeutic Gases in Neonatal Intensive Care
Current Pediatric Reviews Prevention and Treatment of Venous Thromboembolism and Pulmonary Embolism: The Role of Novel Oral Anticoagulants
Current Clinical Pharmacology Systemic Biomarkers in the Evaluation and Management of COPD Patients: Are We Getting Closer to Clinical Application?
Current Drug Targets Lipoprotein(a): Current Perspectives
Current Vascular Pharmacology Nocturnal Blood Pressure Abnormalities in Obstructive Sleep Apnea - Clinical Predictors
Current Respiratory Medicine Reviews Potential Prognostic, Diagnostic and Therapeutic Markers for In-stent Reocclusion in Advanced Age Patients After Coronary Stenting
Current Pharmaceutical Design Impact of Prone Position on Myocardial Perfusion SPECT Interpretation in Women with Suspected Coronary Disease
Current Medical Imaging Antisense DNA and RNA: Potential Therapeutics for Viral Infection
Anti-Infective Agents in Medicinal Chemistry The Glycogen Synthase Kinase-3 in the Regulation of Ion Channels and Cellular Carriers
Current Medicinal Chemistry The Metabolic Syndrome and Chronic Liver Disease
Current Pharmaceutical Design A New Perspective of Cannabinoid 1 Receptor Antagonists: Approaches Toward Peripheral CB1R Blockers without Crossing the Blood-Brain Barrier
Current Topics in Medicinal Chemistry Cellular and Molecular Regulation of Inflammatory Pain, Nociception and Hyperalgesia - The Role of the Transcription Factor NF-κB as the Lynchpin Nocisensor: Hyperalgesic or Analgesic Effect?
Current Immunology Reviews (Discontinued) Novel Peptides: An Alternative Approach for the Treatment of Diabetes Mellitus
Current Drug Therapy Sepsis-induced Cardiomyopathy
Current Cardiology Reviews Cardiovascular Disease and Dyslipidemia: Beyond LDL
Current Pharmaceutical Design Sterol 14α-Demethylase from Trypanosomatidae Parasites as a Promising Target for Designing New Antiparasitic Agents
Current Topics in Medicinal Chemistry