Anticancer Active Illudins: Recent Developments of a Potent Alkylating Compound Class

Title: Anticancer Active Illudins: Recent Developments of a Potent Alkylating Compound Class

Volume: 18 Issue: 6

Author(s): R. Schobert, S. Knauer, S. Seibt and B. Biersack

Affiliation:

Keywords: Alkylating agents, illudins, irofulven, anticancer drugs, fungal agents, spirocyclopropanes, metabolism, bionucleophiles, cyclophosphamide, basidiomycetes, lantern mushroom, mitomycins

Abstract: An overview of anticancer active spirocyclopropanes of the illudin class is provided. After a short introduction on the history and general chemistry of illudins M and S, new discoveries concerning their mode of action and metabolism are reported as well as new synthetic endeavors towards derivatives with improved selectivity for and efficacy against cancer cells. In addition, common and recently tapped biological sources and isolation procedures for known and new illudins are discussed. Pertinent literature is covered up to 2010.

Cite this article as:

Schobert R., Knauer S., Seibt S. and Biersack B., Anticancer Active Illudins: Recent Developments of a Potent Alkylating Compound Class, Current Medicinal Chemistry 2011; 18 (6) . https://dx.doi.org/10.2174/092986711794927766