Parallel Solution-Phase Synthesis of a 2-Aminothiazole Library Including Fully Automated Work-Up

Title: Parallel Solution-Phase Synthesis of a 2-Aminothiazole Library Including Fully Automated Work-Up

Volume: 14 Issue: 2

Author(s): Hans-Peter Buchstaller and Uwe Anlauf

Affiliation:

Keywords: Aminothiazole, combinatorial chemistry, solution phase synthesis, automation, Alzheimer's disease, chronic pain, Huntington's disease, Chemspeed ASW 2000 automated, triethylamine, H NMR spectroscopy, DMF

Abstract: A straightforward and effective procedure for the solution phase preparation of a 2-aminothiazole combinatorial library is described. Reaction, work-up and isolation of the title compounds as free bases was accomplished in a fully automated fashion using the Chemspeed ASW 2000 automated synthesizer. The compounds were obtained in good yields and excellent purities without any further purification procedure.

Cite this article as:

Buchstaller Hans-Peter and Anlauf Uwe, Parallel Solution-Phase Synthesis of a 2-Aminothiazole Library Including Fully Automated Work-Up, Combinatorial Chemistry & High Throughput Screening 2011; 14 (2) . https://dx.doi.org/10.2174/138620711794474024