Abstract
Changes in DNA methylation patterns is a prominent characteristic of human tumors. Tumor cells display reduced levels of genomic DNA methylation and site-specific CpG island hypermethylation. Methylation of CpG dinucleotides is catalyzed by the enzyme family of DNA methyltransferases (DNMTs). In this review, the role of DNA methylation and DNMTs as key determinants of carcinogenesis is further elucidated. The chromatin modifying proteins that are known to interact with DNMTs are also described. Finally, the role of DNMTs as potential therapeutic targets is addressed.
Keywords: Biomarkers, cancer, chromatin modification, CpG methylation, DNMTs, epigenetic therapy, oncogenes, tumor suppressor genes, DNA cytosine-5 methyltransferases, DNA methyltransferases, Aberrant methylation, histone proteins, histone acetyltransferases (HATs), histone methyltransferases, retinoblastoma-associated histone-binding proteins, lymphoid-specific helicase, estrogenreceptor, restriction landmark genomic scanning, RLGS, methylation-specific PCR, heterochromatin, 5-aza-2'-deoxycytidine, Polycomb Repressive Complex 2, PRC2, 5-azacytidine (Vidaza), 5-aza-2'-deoxycytidine (Decitabine), myelodysplastic syndromes, MDS
Current Genomics
Title: Cytosine Methyltransferases as Tumor Markers
Volume: 11 Issue: 8
Author(s): Athanasia Pavlopoulou and Sophia Kossida
Affiliation:
Keywords: Biomarkers, cancer, chromatin modification, CpG methylation, DNMTs, epigenetic therapy, oncogenes, tumor suppressor genes, DNA cytosine-5 methyltransferases, DNA methyltransferases, Aberrant methylation, histone proteins, histone acetyltransferases (HATs), histone methyltransferases, retinoblastoma-associated histone-binding proteins, lymphoid-specific helicase, estrogenreceptor, restriction landmark genomic scanning, RLGS, methylation-specific PCR, heterochromatin, 5-aza-2'-deoxycytidine, Polycomb Repressive Complex 2, PRC2, 5-azacytidine (Vidaza), 5-aza-2'-deoxycytidine (Decitabine), myelodysplastic syndromes, MDS
Abstract: Changes in DNA methylation patterns is a prominent characteristic of human tumors. Tumor cells display reduced levels of genomic DNA methylation and site-specific CpG island hypermethylation. Methylation of CpG dinucleotides is catalyzed by the enzyme family of DNA methyltransferases (DNMTs). In this review, the role of DNA methylation and DNMTs as key determinants of carcinogenesis is further elucidated. The chromatin modifying proteins that are known to interact with DNMTs are also described. Finally, the role of DNMTs as potential therapeutic targets is addressed.
Export Options
About this article
Cite this article as:
Pavlopoulou Athanasia and Kossida Sophia, Cytosine Methyltransferases as Tumor Markers, Current Genomics 2010; 11 (8) . https://dx.doi.org/10.2174/138920210793360916
DOI https://dx.doi.org/10.2174/138920210793360916 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
New insights on Pediatric Tumors and Associated Cancer Predisposition Syndromes
Because of the broad spectrum of children cancer susceptibility, the diagnosis of cancer risk syndromes in children is rarely used in direct cancer treatment. The field of pediatric cancer genetics and genomics will only continue to expand as a result of increasing use of genetic testing tools. It's possible that ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Single-cell Sequencing in the Field of Stem Cells
Current Genomics Self-Assembling Peptides: Potential Role in Tumor Targeting
Current Pharmaceutical Biotechnology Lymphatics and Inflammation
Current Medicinal Chemistry Nutritional and Therapeutic Potential of Garlic and Onion (Allium sp.)
Current Nutrition & Food Science Cancer Invasion and Metastasis: Discovering New Targets For Diagnosis and Therapeutics
Current Signal Transduction Therapy Microfilament Actin Remodeling as a Potential Target for Cancer Drug Development
Current Cancer Drug Targets Pharmacological Modulation of Nitric Oxide Release: New Pharmacological Perspectives, Potential Benefits and Risks
Current Medicinal Chemistry MtDNA As a Cancer Marker: A Finally Closed Chapter?
Current Genomics Down-Regulation of DDR1 Induces Apoptosis and Inhibits EMT through Phosphorylation of Pyk2/MKK7 in DU-145 and Lncap-FGC Prostate Cancer Cell Lines
Anti-Cancer Agents in Medicinal Chemistry The Role of B-Lymphocyte Stimulator in Neuroendocrine Tumors: Correlation with Tumor Differentiation, Disease status and the Presence of Metastases
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Perspectives on Medicinal Properties of Mangiferin
Mini-Reviews in Medicinal Chemistry Putative Breast Tumor Suppressor TACC2 Suppresses the Aggressiveness of Breast Cancer Cells through a PLCγ Pathway
Current Signal Transduction Therapy Hypoxia Responsive Drug Delivery Systems in Tumor Therapy
Current Pharmaceutical Design Recent Advances in Azo Dye Degrading Enzyme Research
Current Protein & Peptide Science Targeted Drug Delivery to Cancer Stem Cells through Nanotechnological Approaches
Current Stem Cell Research & Therapy Vascular Endothelial Growth Factor as an Anti-Angiogenic Target for Cancer Therapy
Current Drug Targets Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy
Current Genomics Multimodality Imaging of CXCR4 in Cancer: Current Status towards Clinical Translation
Current Molecular Medicine Antidotal Effects of Curcumin Against Agents-Induced Cardiovascular Toxicity
Cardiovascular & Hematological Disorders-Drug Targets Potential Role of Rho Kinase Inhibitors in Combating Diabetes-Related Complications Including Diabetic Neuropathy-A Review
Current Diabetes Reviews