The Control of Endoplasmic Reticulum-Initiated Apoptosis by the BCL-2 Family of Proteins

Title: The Control of Endoplasmic Reticulum-Initiated Apoptosis by the BCL-2 Family of Proteins

Volume: 6 Issue: 1

Author(s): Scott A. Oakes, Stephen S. Lin and Michael C. Bassik

Affiliation:

Keywords: BH4-domain, mitochondrion, Homeostasis, Cell Death, IP3 Receptor, transcription factor, NOXA expression

Abstract: Irreversible perturbations in the homeostasis of the endoplasmic reticulum (ER) are thought to lead to apoptosis and cell loss in a number of important human diseases, including Alzheimer disease, Parkinson disease, and type 2 diabetes. However, the exact mechanisms that lead from ER stress to cell death remain incompletely understood. Recent work has shown that the BCL-2 family of proteins plays a central role in regulating this form of cell death, both locally at the ER and from a distance at the mitochondrial membrane.

Cite this article as:

Oakes A. Scott, Lin S. Stephen and Bassik C. Michael, The Control of Endoplasmic Reticulum-Initiated Apoptosis by the BCL-2 Family of Proteins, Current Molecular Medicine 2006; 6 (1) . https://dx.doi.org/10.2174/156652406775574587