Abstract
Intra- and extracellular protein misfolding and aggregation is likely to contribute to a number of age-related central nervous system diseases (“proteinopathies”). Therefore, molecular chaperones, such as heat shock proteins (HSPs), that regulate protein folding, misfolding and adaption to cellular stress are emerging as therapeutic targets. Here we review the current knowledge of HSP-modulating drugs and discuss the opportunities and difficulties of their therapeutic use to treat proteinopathies such as Alzheimers- and Parkinsons disease, the polyglutamine- and prion disorders and Amyotrophic Lateral Sclerosis.
Keywords: Protein misfolding, neuroprotection, proteinopathies, molecular chaperones
Current Pharmaceutical Biotechnology
Title: Heat Shock Proteins: Therapeutic Drug Targets for Chronic Neurodegeneration?
Volume: 11 Issue: 2
Author(s): M. U. Sajjad, B. Samson and A. Wyttenbach
Affiliation:
Keywords: Protein misfolding, neuroprotection, proteinopathies, molecular chaperones
Abstract: Intra- and extracellular protein misfolding and aggregation is likely to contribute to a number of age-related central nervous system diseases (“proteinopathies”). Therefore, molecular chaperones, such as heat shock proteins (HSPs), that regulate protein folding, misfolding and adaption to cellular stress are emerging as therapeutic targets. Here we review the current knowledge of HSP-modulating drugs and discuss the opportunities and difficulties of their therapeutic use to treat proteinopathies such as Alzheimers- and Parkinsons disease, the polyglutamine- and prion disorders and Amyotrophic Lateral Sclerosis.
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Cite this article as:
Sajjad U. M., Samson B. and Wyttenbach A., Heat Shock Proteins: Therapeutic Drug Targets for Chronic Neurodegeneration?, Current Pharmaceutical Biotechnology 2010; 11 (2) . https://dx.doi.org/10.2174/138920110790909641
DOI https://dx.doi.org/10.2174/138920110790909641 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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