The Role of PEDF in Tumor Growth and Metastasis

Title: The Role of PEDF in Tumor Growth and Metastasis

Volume: 10 Issue: 3

Author(s): D. Hoshina, R. Abe, S.-I. Yamagishi and H. Shimizu

Affiliation:

Keywords: PEDF, tumor, growth, metastasis

Abstract: Pigment epithelium-derived factor (PEDF), one of the non-inhibitory serpines, is widely expressed throughout the body. Although PEDF was initially identified as a neuronal differentiation factor, more attention has been paid to its anti-angiogenic activity. Additionally, recent researches have demonstrated that PEDF has an anti-tumor effect against several human neoplasms. This review focuses on the pathological role of PEDF in tumors, especially tumor growth and metastasis. PEDF is an endogenous anti-tumor factor and its clinical application seems quite promising, although there is much to be further investigated.

Cite this article as:

Hoshina D., Abe R., Yamagishi S.-I. and Shimizu H., The Role of PEDF in Tumor Growth and Metastasis, Current Molecular Medicine 2010; 10 (3) . https://dx.doi.org/10.2174/156652410791065327