Abstract
Ethyl-4-thienyl-6-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine carboxyl ate (4) was obtained by the reaction of thiophene-2-carbaldehyde, urea and ethylbenzoylacetate. Reaction of (4) with phosphorous oxy chloride followed by hydrazine hydrate afforded the hydrazide (6), condensation of (6) with D-glucose followed by acetylation gave the acetylated compound (8), which cyclized into triazolopyrimidine derivatives (9) in presence of bromine/acetic acid the deprotection of compound (9) in presence of TEA/MeOH afforded the deprotected compound (10). Selected members of the compounds were screened for antimicrobial activity.
Current Organic Chemistry
Title: Synthesis of Tetrahydropyrimidine Derivatives and its Glycosides
Volume: 13 Issue: 18
Author(s): Wesam S. Shehab
Affiliation:
Abstract: Ethyl-4-thienyl-6-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine carboxyl ate (4) was obtained by the reaction of thiophene-2-carbaldehyde, urea and ethylbenzoylacetate. Reaction of (4) with phosphorous oxy chloride followed by hydrazine hydrate afforded the hydrazide (6), condensation of (6) with D-glucose followed by acetylation gave the acetylated compound (8), which cyclized into triazolopyrimidine derivatives (9) in presence of bromine/acetic acid the deprotection of compound (9) in presence of TEA/MeOH afforded the deprotected compound (10). Selected members of the compounds were screened for antimicrobial activity.
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Cite this article as:
Shehab S. Wesam, Synthesis of Tetrahydropyrimidine Derivatives and its Glycosides, Current Organic Chemistry 2009; 13 (18) . https://dx.doi.org/10.2174/138527209789630451
DOI https://dx.doi.org/10.2174/138527209789630451 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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