Abstract
The considerable biological and medicinal activities of purine nucleoside derivatives have simulated the recent interest in the synthesis of some new purine nucleosides. The present work described the reaction of inosine (1) with triphenylphosphine which led to the formation of 5-chloro-5-deoxy inosine (2), which on reaction with methylamine and morphorine afforded the compounds (3) and (4) respectively. The benzoylation of inosine (1) with benzoylchloride led to the formation of 1-benzoyl inosine (5) followed by reaction with sodium hydroxide affording compound (6). While the treatement of inosine (1) with dichlorodimethylsilane gave the compound (7), which on reaction with ethylacrylate gave 1-etheoxycarbonylethyl-3, 5-O-(di-methylsilanediyl) ether inosine (8). Treatment of inosine (1) with methane sulfonylchloride led to the formation 3,5-dimethanesulfonylinosine (9) which reacted with bormine to give 8-bromo-3,5- dimethanesulfonylinosine (10) was allowed to react with thiourea to give 8-mercapto -3,5-dimehanesulfonylinosine (11). The biological activities of the prepared compounds were also described.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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