Abstract
The reactivity of 5-hydroxy-6-methyluracil (HMU) towards peroxyl radicals generated from the aerobic thermal decomposition of 2,2-azo-bis(2-amidinopropane)dihydrochloride (AAPH) has been investigated. The oxidation product of HMU is dihydro-5,5,6-trihydroxy-6-methylpyrimidin-2,4-dion-e (94%). The relative oxidation rate of HMU vs. quercetin by peroxyl radicals generated from AAPH has been measured as 0.20 ± 0.04 at 54.6°C, hence HMU is the effective scavenger of peroxyl radicals. The overall kinetic parameters and the efficiency of radical generation from AAPH in water solution at pH 7.0 (0.1 M phosphate buffer) have been determined using HMU in temperature range 26° - 84°C.
Current Organic Chemistry
Title: 5-Hydroxy-6-methyluracil, an Efficient Scavenger of Peroxyl Radical in Water
Volume: 13 Issue: 17
Author(s): S. A. Grabovskiy, A. R. Abdrakhmanova, Y. I. Murinov and N. N. Kabal'nova
Affiliation:
Abstract: The reactivity of 5-hydroxy-6-methyluracil (HMU) towards peroxyl radicals generated from the aerobic thermal decomposition of 2,2-azo-bis(2-amidinopropane)dihydrochloride (AAPH) has been investigated. The oxidation product of HMU is dihydro-5,5,6-trihydroxy-6-methylpyrimidin-2,4-dion-e (94%). The relative oxidation rate of HMU vs. quercetin by peroxyl radicals generated from AAPH has been measured as 0.20 ± 0.04 at 54.6°C, hence HMU is the effective scavenger of peroxyl radicals. The overall kinetic parameters and the efficiency of radical generation from AAPH in water solution at pH 7.0 (0.1 M phosphate buffer) have been determined using HMU in temperature range 26° - 84°C.
Export Options
About this article
Cite this article as:
Grabovskiy A. S., Abdrakhmanova R. A., Murinov I. Y. and Kabal'nova N. N., 5-Hydroxy-6-methyluracil, an Efficient Scavenger of Peroxyl Radical in Water, Current Organic Chemistry 2009; 13 (17) . https://dx.doi.org/10.2174/138527209789578081
DOI https://dx.doi.org/10.2174/138527209789578081 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements