Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications

Title: Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications

Volume: 11 Issue: 3

Author(s): C. Oberle and C. Blattner

Affiliation:

Keywords: DNA double strand breaks, homologous recombination, non-homologous endjoining, cell cycle arrest, post-translational modifications

Abstract: Damage to the genetic material can affect cellular function in many ways. Therefore, maintenance of the genetic integrity is of primary importance for all cells. Upon DNA damage, cells respond immediately with proliferation arrest and repair of the lesion or apoptosis. All these consequences require recognition of the lesion and transduction of the information to effector systems. The accomplishment of DNA repair, but also of cell cycle arrest and apoptosis furthermore requires protein-protein interactions and the formation of larger protein complexes. More recent research shows that the formation of many of these aggregates depends on post-translational modifications. In this article, we have summarized the different cellular events in response to a DNA double strand break, the most severe lesion of the DNA.

Cite this article as:

Oberle C. and Blattner C., Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications, Current Genomics 2010; 11 (3) . https://dx.doi.org/10.2174/138920210791110979