Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

NK Cell Receptors and Their Interactions with MHC

Author(s): Roberto Biassoni, Elisabetta Ugolotti and Andrea De Maria

Volume 15, Issue 28, 2009

Page: [3301 - 3310] Pages: 10

DOI: 10.2174/138161209789105225

Price: $65

Abstract

MHC-specific Natural Killer inhibitory receptors display a conserved and fundamental function in the regulation of NK-mediated cytolysis. Their importance is substantiated by the fact that during speciation different molecular receptor structures have evolved to maintain inhibitory regulation of NK cells. The information gained during these last twenty years begins to be fruitfully used in the therapy of leukemias, but a lot has to be still done. In particular, we need to understand the role of activating KIR and their ligand(s), since their role in the course of different viral diseases is still intriguing.

Keywords: Killer inhibitory receptor, human leukocyte antigen, activating receptors, sialoadhesin


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy