Abstract
The use of nanoscale structures and features is becoming increasingly popular in tissue engineering, and for good reason. Devices that have features in the nano-length scale offer many benefits that their counterparts do not. These features can alter cellular behavior including cell attachment, degree of cell spreading, and cellular alignment. These properties affect the arrangement of extracellular matrix material produced by attached cells. Nano to micro-scale porosity is important for cellular infiltration into long term or degradable implants. Features of this length scale model the structures that cells typically see in vivo, therefore they tend to respond positively when placed on nano length structures. The inclusion of nanoscale features or use of nanoscale structures improves the cellular response to the implant and increases tissue bonding thereby reducing the chances of implant failure. Nanoscale structures can also enhance device strength; by combining nanoscale, high moduli particles with more flexible, weaker materials one can create high strength composites for bone tissue engineering. There are a host of ways to create nanostructures or create nanoscale features on an implant including electrospinning, nanoetching, and the creation of nanospheres. They all produce roughness, pores, or alignment in the nanoscale which is essential for tissue engineering success. These techniques encompass a wide range of materials and methods. Several of these techniques and their applications will be discussed in this paper.
Current Bioactive Compounds
Title: Nanostructures for Treating Musculoskeletal Conditions
Volume: 5 Issue: 3
Author(s): Joseph W. Freeman and M. Nichole Rylander
Affiliation:
Abstract: The use of nanoscale structures and features is becoming increasingly popular in tissue engineering, and for good reason. Devices that have features in the nano-length scale offer many benefits that their counterparts do not. These features can alter cellular behavior including cell attachment, degree of cell spreading, and cellular alignment. These properties affect the arrangement of extracellular matrix material produced by attached cells. Nano to micro-scale porosity is important for cellular infiltration into long term or degradable implants. Features of this length scale model the structures that cells typically see in vivo, therefore they tend to respond positively when placed on nano length structures. The inclusion of nanoscale features or use of nanoscale structures improves the cellular response to the implant and increases tissue bonding thereby reducing the chances of implant failure. Nanoscale structures can also enhance device strength; by combining nanoscale, high moduli particles with more flexible, weaker materials one can create high strength composites for bone tissue engineering. There are a host of ways to create nanostructures or create nanoscale features on an implant including electrospinning, nanoetching, and the creation of nanospheres. They all produce roughness, pores, or alignment in the nanoscale which is essential for tissue engineering success. These techniques encompass a wide range of materials and methods. Several of these techniques and their applications will be discussed in this paper.
Export Options
About this article
Cite this article as:
Freeman W. Joseph and Rylander Nichole M., Nanostructures for Treating Musculoskeletal Conditions, Current Bioactive Compounds 2009; 5 (3) . https://dx.doi.org/10.2174/157340709789054731
DOI https://dx.doi.org/10.2174/157340709789054731 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cell-penetrating Peptide-based Intelligent Liposomal Systems for Enhanced Drug Delivery
Current Pharmaceutical Biotechnology Radial Approach for Percutaneous Coronary Intervention
Reviews on Recent Clinical Trials Chalcones Incorporated Pyrazole Ring Inhibit Proliferation, Cell Cycle Progression, Angiogenesis and Induce Apoptosis of MCF7 Cell Line
Anti-Cancer Agents in Medicinal Chemistry Passive Targeting of Cyclophosphamide-Loaded Carbonate Apatite Nanoparticles to Liver Impedes Breast Tumor Growth in a Syngeneic Model
Current Pharmaceutical Design In Silico Design, Synthesis and Bioactivity of N-(2, 4-Dinitrophenyl)-3-oxo- 3-phenyl-N-(aryl) Phenyl Propanamide Derivatives as Breast Cancer Inhibitors
Current Computer-Aided Drug Design Structure and Ligand Based Drug Design Strategies in the Development of Novel 5- LOX Inhibitors
Current Medicinal Chemistry Osteoporosis Requires Bone-Specific Statins
Current Pharmaceutical Design Development of Peptide and Protein Based Radiopharmaceuticals
Current Pharmaceutical Design Alginates in Pharmaceutics and Biomedicine: Is the Future so Bright?
Current Pharmaceutical Design HIF-1α Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms
Mini-Reviews in Medicinal Chemistry Scaffold Vascularization: A Challenge for Three-Dimensional Tissue Engineering
Current Medicinal Chemistry Nitric Oxide and Disorders of the Erythrocyte: Emerging Roles and Therapeutic Targets
Cardiovascular & Hematological Disorders-Drug Targets Dibenzofurans from Lichens – A Pharmacological Overview
Current Topics in Medicinal Chemistry Novel Strategies for the Treatment of Asthma
Recent Patents on Inflammation & Allergy Drug Discovery Impact of Inhibitors of the Renin-Angiotensin-Aldosterone System on Liver Fibrosis and Portal Hypertension
Current Medicinal Chemistry RNA Interference as a Therapeutic Strategy for the Treatment of Liver Diseases
Current Pharmaceutical Design Mechanism of Drug Sensitivity and Resistance in Melanoma
Current Cancer Drug Targets Effectors of Fatty Acid Oxidation Reduction: Promising New Anti-Ischaemic Agents
Current Pharmaceutical Design Targeting Lipoxygenases (LOs): Drug Design And Discovery
Current Enzyme Inhibition The Therapeutic Potential of Cell-Internalizing Aptamers
Current Topics in Medicinal Chemistry