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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Mini-Review Article

Synthesis and Biological Applications of Coumarinyl-Chalcones

Author(s): Sayed K. Ramadan*, Sameh A. Rizk and Eman A.E. El-Helw

Volume 28, Issue 12, 2024

Published on: 10 May, 2024

Page: [897 - 904] Pages: 8

DOI: 10.2174/0113852728248318240418092208

Price: $65

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Abstract

This survey provides information on the synthesis and biological applications of coumarinyl-chalcones. Chalcones are unsaturated ketones involving the reactive ketoethylenic group (CO-CH=CH). Chalcones are naturally abundant in many medical plants, including vegetables, fruits, and foods. Natural and synthetic chalcone compounds exhibit a broad spectrum of biological properties like anticancer, anti-inflammatory, anti-HIV, antioxidant, antimalarial, and antimicrobial. Some conventional, microwave, and grinding techniques have been utilized for the synthesis of chalcones. Noteworthy, the Claisen- Schmidt condensation reaction remains the most popular and effective method for synthesis. It summarizes information about its synthetic methods as building blocks in some reactions like cyclization reactions and medical applications. This review article presents an overview of approaches and biological data for chalcones bearing a coumarin scaffold.

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Graphical Abstract

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