Green Synthesis of Silver Nanoparticles and their Potential Applications in Mitigating Cancer

Title:Green Synthesis of Silver Nanoparticles and their Potential Applications in Mitigating Cancer

Volume: 30 Issue: 31

Author(s): Reyaz Hassan Mir, Mudasir Maqbool, Prince Ahad Mir, Md. Sadique Hussain, Shahid Ud Din Wani, Faheem Hyder Pottoo*Roohi Mohi-ud-din*

Affiliation:

• Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia

• Department of General Medicine, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Jammu and Kashmir 190001, India

Abstract: In recent years, the field of nanotechnology has brought about significant advancements that have transformed the landscape of disease diagnosis, prevention, and treatment, particularly in the realm of medical science. Among the various approaches to nanoparticle synthesis, the green synthesis method has garnered increasing attention. Silver nanoparticles (AgNPs) have emerged as particularly noteworthy nanomaterials within the spectrum of metallic nanoparticles employed for biomedical applications. AgNPs possess several key attributes that make them highly valuable in the biomedical field. They are biocompatible, cost-effective, and environmentally friendly, rendering them suitable for various bioengineering and biomedical applications. Notably, AgNPs have found a prominent role in the domain of cancer diagnosis. Research investigations have provided evidence of AgNPs' anticancer activity, which involves mechanisms such as DNA damage, cell cycle arrest, induction of apoptosis, and the regulation of specific cytokine genes. The synthesis of AgNPs primarily involves the reduction of silver ions by reducing agents. Interestingly, natural products and living organisms have proven to be effective sources for the generation of precursor materials used in AgNP synthesis. This comprehensive review aims to summarize the key aspects of AgNPs, including their characterization, properties, and recent advancements in the field of biogenic AgNP synthesis. Furthermore, the review highlights the potential applications of these nanoparticles in combating cancer.

Cite this article as:

Mir Hassan Reyaz, Maqbool Mudasir, Mir Ahad Prince, Hussain Sadique Md., Wani Shahid Ud Din, Pottoo Hyder Faheem*, Mohi-ud-din Roohi*, Green Synthesis of Silver Nanoparticles and their Potential Applications in Mitigating Cancer, Current Pharmaceutical Design 2024; 30 (31) . https://dx.doi.org/10.2174/0113816128291705240428060456