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Nanoscience & Nanotechnology-Asia

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ISSN (Print): 2210-6812
ISSN (Online): 2210-6820

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Research Article

Formulation and Evaluation of Transdermal Niosomal Gel for Antihyperlipidemic Agent

Author(s): Pravin Patil*, Priyanka Bhagwat, Pournima Sankpal, Sachinkumar Patil and Shashikant Dhawale

Volume 14, Issue 2, 2024

Published on: 18 April, 2024

Article ID: e180424229068 Pages: 10

DOI: 10.2174/0122106812257984240416113059

Price: $65

Abstract

Aims: The current study aims to create a formulation of Fluvastatin sodium (FVS) loaded niosome for the treatment of antihyperlipidemia using thin film hydration. The developed formulations were statistically optimized by two factors, three levels by 3-level factorial design and were evaluated for vesicle size, entrapment efficiency, zeta potential, transmission electron microscopy, and in-vitro drug release.

Methods: The optimized FVS niosome being transformed to gel formulation was likewise analyzed for in-vitro skin permeability study, lipase action, and stability study.

Results: The composition of an improved FVS niosome revealed vesicle size, entrapment effectiveness, zeta potential of 105.3 ± 12.4nm, 74.5 ± 0.86% and -36.2 ± 7mV, respectively, with spherical morphology.

Conclusion: The FVS Niosomal gel demonstrated improved skin permeation compared to Orlistat. Furthermore, lipase activity showed better activity when compared with standard Orlistat drugs. Niosomal particles were discovered as a reliable nanovesicular carrier for the transdermal administration of FVS.

Graphical Abstract

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