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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

The Chemistry of Aldehydes and Ketones in the Synthesis of Heterocycles - Historical Reactions with a New and Green Perspective

Author(s): Flavia Martins da Silva, Joel Jones Junior* and July A. Hernández Muñoz

Volume 28, Issue 13, 2024

Published on: 18 March, 2024

Page: [1023 - 1045] Pages: 23

DOI: 10.2174/0113852728295534240223044735

Price: $65

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Abstract

The reactivity of aldehydes and ketones carries great potential for multicomponent heterocyclizations. These reactions are convergent and highly versatile in the development of synthetic methodologies for compound families, displaying variations in substituents in their structures. Therefore, they have been regarded as an important tool in the field of Green Chemistry. Furthermore, they prove to be very useful in studies of biological activity, where small structural modifications can result in significant differences. Many heterocyclizations date back to the mid-19th and early 20th centuries. In this review, we aim to demonstrate, through some of these reactions, their continuously growing potential and improvements concerning synthetic development. Additionally, we present the original studies as reported, enabling us to appreciate the evolution of chemical representations over the years until reaching the standardization we have today.

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