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Current Cardiology Reviews

Editor-in-Chief

ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

Meta-Analysis

Impact of Caffeine Intake Strategies on Heart Rate Variability during Post-Exercise Recovery: A Systematic Review and Meta-Analysis

Author(s): Bianca Araujo Almeida*, Anderson Pontes Morales, José Ricardo Claudino Ribeiro, Felipe Sampaio-Jorge, Yasmin Garcia Ribeiro, Thiago Barth and Beatriz Gonçalves Ribeiro

Volume 20, Issue 3, 2024

Published on: 14 March, 2024

Article ID: e140324227991 Pages: 14

DOI: 10.2174/011573403X289842240307114736

Price: $65

Abstract

Objectives: The objective of this systematic review and meta-analysis is to evaluate the influence of caffeine (CAF) intake strategies, taking into account their form, timing, and dosage, on heart rate variability (HRV) indices in the post-exercise recovery period.

Methods: The meta-analysis adhered to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines and is registered in the PROSPERO database (CRD42023425885). A comprehensive literature search was carried out across MEDLINE, Web of Science, LILACS, and SCOPUS, concluding in May 2023. We concentrated on randomized clinical trials comparing CAF supplementation effects to placebo on HRV indices post-exercise in active adults aged 18 and above. The primary endpoint was the assessment of HRV indices, measured both prior to and following exercise.

Results: Of the 10 studies included, 7 were used for the meta-analysis, and all contributed to the systematic review. The research explored a variety of CAF strategies, spanning different forms (capsule, drink, gum), times (10, 45, 60 min) and doses (2.1 to 6.0 mg/kg). The outcomes revealed no substantial variations between the placebo and CAF conditions in terms of both the square root of the average of successive squared differences between adjacent RR intervals (RMSSD) (standardized mean difference (SMD) -0.03, 95% CI -0.265 to 0.197, p=0.77) and high frequency (HF) index (SMD -0.061, 95% CI -0.272 to 0.150, p=0.57). Furthermore, metaregression analysis, employing a fixed-effects model and accounting for the administered CAF doses, revealed no significant correlation between caffeine doses and HRV indices (p>0.05).

Conclusion: In conclusion, there is moderate-certainty evidence suggesting that different CAF intake strategies, encompassing aspects such as form, time, and dose, do not have a significant impact on HRV indices recovery post-exercise (i.e., vagal modulation).

Graphical Abstract

[1]
Mitchell DC, Knight CA, Hockenberry J, Teplansky R, Hartman TJ. Beverage caffeine intakes in the U.S. Food Chem Toxicol 2014; 63: 136-42.
[http://dx.doi.org/10.1016/j.fct.2013.10.042] [PMID: 24189158]
[2]
Southward K, Rutherfurd-Markwick KJ, Ali A. The effect of acute caffeine ingestion on endurance performance: A systematic review and meta-Analysis. Sports Med 2018; 48(8): 1913-28.
[http://dx.doi.org/10.1007/s40279-018-0939-8] [PMID: 29876876]
[3]
Ferreira RES, Pacheco RL, de Oliveira Cruz Latorraca C, Riera R, Eid RG, Martimbianco ALC. Effects of caffeine supplementation on physical performance of soccer players: Systematic review and meta-analysis. Sports Health 2021; 13(4): 347-58.
[http://dx.doi.org/10.1177/1941738121998712] [PMID: 33666113]
[4]
Grgic J, Grgic I, Pickering C, Schoenfeld BJ, Bishop DJ, Pedisic Z. Wake up and smell the coffee: Caffeine supplementation and exercise performance—an umbrella review of 21 published meta-analyses. Br J Sports Med 2020; 54(11): 681-8.
[http://dx.doi.org/10.1136/bjsports-2018-100278] [PMID: 30926628]
[5]
Southward K, Rutherfurd-Markwick K, Badenhorst C, Ali A. The role of genetics in moderating the inter-individual differences in the ergogenicity of caffeine. Nutrients 2018; 10(10): 1352.
[http://dx.doi.org/10.3390/nu10101352] [PMID: 30248915]
[6]
Karayigit R, Naderi A, Akca F, et al. Effects of different doses of caffeinated coffee on muscular endurance, cognitive performance, and cardiac autonomic modulation in caffeine naive female athletes. Nutrients 2020; 13(1): 2.
[http://dx.doi.org/10.3390/nu13010002] [PMID: 33374947]
[7]
Guest NS, VanDusseldorp TA, Nelson MT, et al. International society of sports nutrition position stand: Caffeine and exercise performance. J Int Soc Sports Nutr 2021; 18(1): 1.
[http://dx.doi.org/10.1186/s12970-020-00383-4] [PMID: 33388079]
[8]
Scientific opinion on the safety of caffeine. EFSA Journal 2015; 13(5): 1-4102.
[9]
EFSA Fact sheets on caffeine. Available from: http://www.efsa.europa.eu/en/corporate/pub/efsaexplainscaffeine150527 (Accessed on 31th May 2023).
[10]
BRAZIL. Ministry of health. National health surveillance agency (ANVISA). Resolution of the collegiate board. 2010. Available from: https://bvsms.saude.gov.br/bvs/saudelegis/anvisa/2010/res0018_27_04_2010.html (Accessed on 31th May 2023).
[11]
Sargent CT, Shahbal TK, Carrillo AE, et al. Effects of low dose caffeine on post-exercise heart rate variability: A double-blind placebo-controlled trial. Int J Exerc Sci 2021; 15(2): 103-12.
[PMID: 36895796]
[12]
Benjamim CJR, Monteiro LRL, Pontes YMM, et al. Caffeine slows heart rate autonomic recovery following strength exercise in healthy subjects. Portuguese J Cardio 2021; 40(6): 399-406.
[http://dx.doi.org/10.1016/j.repce.2020.07.021] [PMID: 34274079]
[13]
Schwabe U, Ukena D, Lohse MJ. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol 1985; 330(3): 212-21.
[http://dx.doi.org/10.1007/BF00572436] [PMID: 2997628]
[14]
Okudaira N, Kuwahara M, Hirata Y, Oku Y, Nishio H. A knock-in mouse model of N-terminal R420W mutation of cardiac ryanodine receptor exhibits arrhythmogenesis with abnormal calcium dynamics in cardiomyocytes. Biochem Biophys Res Commun 2014; 452(3): 665-8.
[http://dx.doi.org/10.1016/j.bbrc.2014.08.132] [PMID: 25193700]
[15]
Palatini P. Exercise capacity and mortality. N Engl J Med 2002; 347(4): 288-90.
[http://dx.doi.org/10.1056/NEJM200207253470413] [PMID: 12140308]
[16]
Nanas S, Anastasiou-Nana M, Dimopoulos S, et al. Early heart rate recovery after exercise predicts mortality in patients with chronic heart failure. Int J Cardiol 2006; 110(3): 393-400.
[http://dx.doi.org/10.1016/j.ijcard.2005.10.032] [PMID: 16371237]
[17]
Sampaio-Jorge F, Morales AP, Pereira R, Barth T, Ribeiro BG. Caffeine increases performance and leads to a cardioprotective effect during intense exercise in cyclists. Sci Rep 2021; 11(1): 24327.
[http://dx.doi.org/10.1038/s41598-021-03158-2] [PMID: 34934054]
[18]
Gonzaga LA, Vanderlei LCM, Gomes RL, Valenti VE. Caffeine affects autonomic control of heart rate and blood pressure recovery after aerobic exercise in young adults: A crossover study. Sci Rep 2017; 7(1): 14091.
[http://dx.doi.org/10.1038/s41598-017-14540-4] [PMID: 29075019]
[19]
Bunsawat K, White DW, Kappus RM, Baynard T. Caffeine delays autonomic recovery following acute exercise. Eur J Prev Cardiol 2015; 22(11): 1473-9.
[http://dx.doi.org/10.1177/2047487314554867] [PMID: 25297344]
[20]
Thomas RM, Algrain HA, Ryan EJ, et al. Influence of a CYP1A2 polymorphism on post-exercise heart rate variability in response to caffeine intake: A double-blind, placebo-controlled trial. Ir J Med Sci 2017; 186(2): 285-91.
[http://dx.doi.org/10.1007/s11845-016-1478-7] [PMID: 27363424]
[21]
Sarshin A, Naderi A, da Cruz CJG, et al. The effects of varying doses of caffeine on cardiac parasympathetic reactivation following an acute bout of anaerobic exercise in recreational athletes. J Int Soc Sports Nutr 2020; 17(1): 44.
[http://dx.doi.org/10.1186/s12970-020-00373-6] [PMID: 32819393]
[22]
Yeragani VK, Krishnan S, Engels HJ, Gretebeck R. Effects of caffeine on linear and nonlinear measures of heart rate variability before and after exercise. Depress Anxiety 2005; 21(3): 130-4.
[http://dx.doi.org/10.1002/da.20061] [PMID: 15965989]
[23]
Nawrot P, Jordan S, Eastwood J, Rotstein J, Hugenholtz A, Feeley M. Effects of caffeine on human health. Food Addit Contam 2003; 20(1): 1-30.
[http://dx.doi.org/10.1080/0265203021000007840] [PMID: 12519715]
[24]
Benjamim CJR, Kliszczewicz B, Garner DM, et al. Is caffeine recommended before exercise? A systematic review to investigate its impact on cardiac autonomic control via heart rate and its variability. J Am Coll Nutr 2020; 39(6): 563-73.
[http://dx.doi.org/10.1080/07315724.2019.1705201] [PMID: 31860391]
[25]
Porto AA, Benjamim CJR, Gonzaga LA, et al. Caffeine intake and its influences on heart rate variability recovery in healthy active adults after exercise: A systematic review and meta-analysis. Nutr Metab Cardiovasc Dis 2022; 32(5): 1071-82.
[http://dx.doi.org/10.1016/j.numecd.2022.01.015] [PMID: 35272883]
[26]
Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. Rev Esp Cardiol 2021; 74(9): 790-9.
[http://dx.doi.org/10.1016/j.rec.2021.07.010] [PMID: 34446261]
[27]
Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. Cochrane handbook for systematic reviews of interventions. Chichester, UK: John Wiley & Sons 2019; pp. 1-694.
[http://dx.doi.org/10.1002/9781119536604]
[28]
Eldridge S, Campbell M, Campbell M, Dahota A, Giraudeau B, Higgins J, et al. Revised cochrane risk of bias tool for randomized trials (RoB 2.0): Additional considerations for cluster-randomized trials. Cochrane Meth Cochrane Database Syst Rev 2016; 126: 37-44.
[29]
Atkins D, Best D, Briss PA, et al. Grading quality of evidence and strength of recommendations. BMJ 2004; 328(7454): 1490.
[http://dx.doi.org/10.1136/bmj.328.7454.1490] [PMID: 15205295]
[30]
Guyatt GH, Oxman AD, Vist G, et al. GRADE guidelines: 4. Rating the quality of evidence—study limitations (risk of bias). J Clin Epidemiol 2011; 64(4): 407-15.
[http://dx.doi.org/10.1016/j.jclinepi.2010.07.017] [PMID: 21247734]
[31]
Melsen WG, Bootsma MCJ, Rovers MM, Bonten MJM. The effects of clinical and statistical heterogeneity on the predictive values of results from meta-analyses. Clin Microbiol Infect 2014; 20(2): 123-9.
[http://dx.doi.org/10.1111/1469-0691.12494] [PMID: 24320992]
[32]
Catai AM, Pastre CM, Godoy MF, Silva E, Takahashi ACM, Vanderlei LCM. Heart rate variability: Are you using it properly? Standardisation checklist of procedures. Braz J Phys Ther 2020; 24(2): 91-102.
[http://dx.doi.org/10.1016/j.bjpt.2019.02.006] [PMID: 30852243]
[33]
Gonçalves Ribeiro B, Pontes Morales A, Sampaio-Jorge F, Tinoco FS, Matos AA, Leite TC. Acute effects of caffeine intake on athletic performance: A systematic review and meta-analysis. Rev Chil Nutr 2017; 44(3): 283-91.
[http://dx.doi.org/10.4067/S0717-75182017000300283]
[34]
Ribeiro BG, Morales AP, Sampaio-Jorge F, et al. Caffeine attenuates decreases in leg power without increased muscle damage. J Strength Cond Res 2016; 30(8): 2354-60.
[http://dx.doi.org/10.1519/JSC.0000000000001332] [PMID: 26808856]
[35]
Lahiri MK, Chicos A, Bergner D, et al. Recovery of heart rate variability and ventricular repolarization indices following exercise. Ann Noninvasive Electrocardiol 2012; 17(4): 349-60.
[http://dx.doi.org/10.1111/j.1542-474X.2012.00527.x] [PMID: 23094881]
[36]
da Silva Rolim P, da Costa Matos RA, Von Koenig Soares EMK, Molina GE, da Cruz CJG. Caffeine increases parasympathetic reactivation without altering resting and exercise cardiac parasympathetic modulation: A balanced placebo design. Eur J Sport Sci 2019; 19(4): 490-8.
[http://dx.doi.org/10.1080/17461391.2018.1532532] [PMID: 30326789]
[37]
Wickham KA, Spriet LL. Administration of caffeine in alternate forms. Sports Med 2018; 48(S1): 79-91.
[http://dx.doi.org/10.1007/s40279-017-0848-2] [PMID: 29368182]
[38]
Graham TE. Caffeine and exercise. Sports Med 2001; 31(11): 785-807.
[http://dx.doi.org/10.2165/00007256-200131110-00002] [PMID: 11583104]
[39]
Turnbull D, Rodricks JV, Mariano GF, Chowdhury F. Caffeine and cardiovascular health. Regul Toxicol Pharmacol 2017; 89: 165-85.
[http://dx.doi.org/10.1016/j.yrtph.2017.07.025] [PMID: 28756014]
[40]
Morales AP, Sampaio-Jorge F, Barth T, Pierucci APTR, Ribeiro BG. Caffeine supplementation for 4 days does not induce tolerance to the ergogenic effects promoted by acute intake on physiological, metabolic, and performance parameters of cyclists: A randomized, double-Blind, crossover, placebo-controlled study. Nutrients 2020; 12(7): 2101.
[http://dx.doi.org/10.3390/nu12072101] [PMID: 32708555]
[41]
Beaumont R, Cordery P, Funnell M, Mears S, James L, Watson P. Chronic ingestion of a low dose of caffeine induces tolerance to the performance benefits of caffeine. J Sports Sci 2017; 35(19): 1920-7.
[http://dx.doi.org/10.1080/02640414.2016.1241421] [PMID: 27762662]
[42]
Ruiz-Moreno C, Lara B, Salinero JJ, Brito de Souza D, Ordovás JM, Del Coso J. Time course of tolerance to adverse effects associated with the ingestion of a moderate dose of caffeine. Eur J Nutr 2020; 59(7): 3293-302.
[http://dx.doi.org/10.1007/s00394-019-02167-2] [PMID: 31900579]
[43]
van Dam RM, Hu FB, Willett WC. Coffee, caffeine, and health. N Engl J Med 2020; 383(4): 369-78.
[http://dx.doi.org/10.1056/NEJMra1816604] [PMID: 32706535]
[44]
Godos J, Pluchinotta FR, Marventano S, et al. Coffee components and cardiovascular risk: Beneficial and detrimental effects. Int J Food Sci Nutr 2014; 65(8): 925-36.
[http://dx.doi.org/10.3109/09637486.2014.940287] [PMID: 25046596]
[45]
Fredholm BB. Adenosine receptors. Med Biol 1982; 60(6): 289-93.
[PMID: 6298509]
[46]
Johansson B, Georgiev V, Lindström K, Fredholm BB. A1 and A2A adenosine receptors and A1 mRNA in mouse brain: effect of long-term caffeine treatment. Brain Res 1997; 762(1-2): 153-64.
[http://dx.doi.org/10.1016/S0006-8993(97)00378-8] [PMID: 9262169]
[47]
Dubroqua S, Yee BK, Singer P. Sensorimotor gating is disrupted by acute but not chronic systemic exposure to caffeine in mice. Psychopharmacology 2014; 231(21): 4087-98.
[http://dx.doi.org/10.1007/s00213-014-3548-8] [PMID: 24728602]
[48]
Li Y, Zhang W, Shi R, et al. Prenatal caffeine damaged learning and memory in rat offspring mediated by ARs/PKA/CREB/BDNF pathway. Physiol Res 2018; 67(6): 975-83.
[http://dx.doi.org/10.33549/physiolres.933906] [PMID: 30204465]
[49]
Chern Y, Lai HL, Fong JC, Liang Y. Multiple mechanisms for desensitization of A2a adenosine receptor-mediated cAMP elevation in rat pheochromocytoma PC12 cells. Mol Pharmacol 1993; 44(5): 950-8.
[PMID: 8246918]
[50]
Karayigit R, Forbes SC, Osmanov Z, et al. Low and moderate doses of caffeinated coffee improve repeated sprint performance in female team sport athletes. Biology 2022; 11(10): 1498.
[http://dx.doi.org/10.3390/biology11101498] [PMID: 36290401]
[51]
Menezes JL, Aidar FJ, Badicu G, et al. Does caffeine supplementation associated with paralympic powerlifting training interfere with hemodynamic indicators? Biology 2022; 11(12): 1843.
[http://dx.doi.org/10.3390/biology11121843] [PMID: 36552351]
[52]
Glaister M, Williams BH, Muniz-Pumares D, Balsalobre-Fernández C, Foley P. The effects of caffeine supplementation on physiological responses to submaximal exercise in endurance-trained men. PLoS One 2016; 11(8): e0161375.
[http://dx.doi.org/10.1371/journal.pone.0161375] [PMID: 27532605]
[53]
Valero F, González-Mohíno F, Salinero JJ. Belief that caffeine ingestion improves performance in a 6-minute time trial test without affecting pacing strategy. Nutrients 2024; 16(2): 327.
[http://dx.doi.org/10.3390/nu16020327] [PMID: 38276565]
[54]
Mone P, Guerra G, Verderosa S, Santulli G, Komici K. Effects of moderate caffeine intake in athletes. Eur J Intern Med 2024; 119: 139-40.
[http://dx.doi.org/10.1016/j.ejim.2023.09.018] [PMID: 37775431]
[55]
Delleli S, Ouergui I, Messaoudi H, Ballmann CG, Ardigò LP, Chtourou H. Effects of caffeine consumption combined with listening to music during warm-up on taekwondo physical performance, perceived exertion and psychological aspects. PLoS One 2023; 18(10): e0292498.
[http://dx.doi.org/10.1371/journal.pone.0292498] [PMID: 37871019]
[56]
Venier S, Grgic J, Mikulic P. Acute enhancement of jump performance, muscle strength, and power in resistance-trained men after consumption of caffeinated chewing gum. Int J Sports Physiol Perform 2019; 14(10): 1415-21.
[http://dx.doi.org/10.1123/ijspp.2019-0098] [PMID: 30958062]
[57]
Siquier-Coll J, Delgado-García G, Soto-Méndez F, Liñán-González A, García R, González-Fernández FT. The effect of caffeine supplementation on female volleyball players’ performance and wellness during a regular training week. Nutrients 2023; 16(1): 29.
[http://dx.doi.org/10.3390/nu16010029] [PMID: 38201859]
[58]
Zhang Y, Diao P, Wang J, et al. The effect of post-activation potentiation enhancement alone or in combination with caffeine on anaerobic performance in boxers: A double-blind, randomized crossover study. Nutrients 2024; 16(2): 235.
[http://dx.doi.org/10.3390/nu16020235] [PMID: 38257128]

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