Antimalarial Effects of Nano Chloroquine Loaded Curcumin In vivo

Title:Antimalarial Effects of Nano Chloroquine Loaded Curcumin In vivo

Volume: 24 Issue: 8

Author(s): Taher Elmi, Fatemeh Tabatabaie*, Mehdi Shafiee Ardestani, Abdolhossein Dalimi, Fatemeh Ghaffarifar, Zahra Zamani and Fatemeh Maleki*

Affiliation:

• Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

• Department of Parasitology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran

Abstract:

Background: Malaria is still the deadliest parasitic disease caused by Plasmodium spp. Due to drug resistance and their unpleasant side effects, of conventional researchers are enormously seeking to achieve antimalarial drugs with more curative effective, less toxic and cost-affordable drugs using more advanced technology such as nanodrugs.

Purpose: The present study aimed to examine the antimalarial effects of a novel synthesized nonochloroquine-loaded curcumin relying on dendrimer G2 in susceptible mice.

Methods: Antimalarial activity and toxicity of the nanocomposite were examined on BALB/C mice with microscopy, checking RBCs morphology and related enzymatic activity rate.

Results: The maximum inhibitory effect of the nanocomposite was seen at 10 mg/kg, killing 98% of P. berghei compared to sole chloroquine, whereas ED50 was reported at 5.5 mg/kg. The safety of the synthesized nanocomposite was confirmed with biochemical tests with no detrimental effects on mice. The sustainability and longevity of the nanodrug increased significantly with the NDC-CQ assay compared to the control groups.

Conclusion: The study showed that nonochloroquine-loaded curcumin had a promising inhibitory effect on P. berghei growth in infected mice compared to standard drugs. However, further studies and clinical trials with large samples are recommended to study different aspects of using nanodrug.

Cite this article as:

Elmi Taher, Tabatabaie Fatemeh*, Ardestani Shafiee Mehdi, Dalimi Abdolhossein, Ghaffarifar Fatemeh, Zamani Zahra and Maleki Fatemeh*, Antimalarial Effects of Nano Chloroquine Loaded Curcumin In vivo, Infectious Disorders - Drug Targets 2024; 24 (8) : e110324227851 . https://dx.doi.org/10.2174/0118715265276270240222070244