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Infectious Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Editorial

The Intriguing Connection between Cholestasis and the Renin-Angiotensin System Dysregulation Induced by SARS-CoV-2 and/or the Vaccinal Spike Protein

Author(s): Ziad Fajloun, Ziad Abi Khattar and Jean-Marc Sabatier*

Volume 24, Issue 7, 2024

Published on: 08 March, 2024

Article ID: e080324227802 Pages: 3

DOI: 10.2174/0118715265304515240220105152

Price: $65

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[9]
Fajloun Z, Sabatier JM. The unsuspected role of the renin-angiotensin system (ras): could its dysregulation be at the root of all non-genetic human diseases? Infect Disord Drug Targets 2024; 24(1): e140923221085. Advance online publication
[http://dx.doi.org/10.2174/1871526524666230914114524] [PMID: 37711109]
[10]
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[11]
Glaser S S, Onori P, Wise C, et al. Recent advances in the regulation of cholangiocyte proliferation and function during extrahepatic cholestasis. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2010; 42(4): 245-52.
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[12]
Annweiler C, Cao Z, Wu Y, et al. Counter-regulatory ‘renin-angiotensin’ system-based candidate drugs to treat COVID-19 diseases in SARS-CoV-2-infected Patients. Infect Disord Drug Targets 2020; 20(4): 407-8.
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[13]
Coto E, Avanzas P, Gómez J. The renin–angiotensin–aldosterone system and coronavirus disease 2019. Eur Cardiol 2021; 16: e07.
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[14]
El-Arif G, Farhat A, Khazaal S, et al. The renin-angiotensin system: A key role in SARS-CoV-2-Induced COVID-19. Molecules 2021; 26(22): 6945.
[http://dx.doi.org/10.3390/molecules26226945] [PMID: 34834033]
[15]
El-Arif G, Khazaal S, Farhat A, et al. Angiotensin II type i receptor (AT1R): The gate towards COVID-19-associated diseases. Molecules 2022; 27(7): 2048.
[http://dx.doi.org/10.3390/molecules27072048] [PMID: 35408447]
[16]
Khazaal S, Harb J, Rima M, et al. The pathophysiology of long COVID throughout the renin-angiotensin system. Molecules 2022; 27(9): 2903.
[http://dx.doi.org/10.3390/molecules27092903] [PMID: 35566253]
[17]
Sabatier J-M, Fajloun Z, Legros C. COVID-19 and ehlers-danlos syndrome: The dangers of the spike protein of SARS-CoV-2. Infect Disord Drug Targets 2023; 23(3): e040123212375.
[http://dx.doi.org/10.2174/1871526523666230104145108] [PMID: 36600622]
[18]
Fajloun Z, Abi Khattar Z, Kovacic H, Legros C, Sabatier JM. Why do athletes develop very severe or fatal forms of covid after intense exercise following SARS-CoV-2 Infection or Anti-COVID Vaccination? Infect Disord Drug Targets 2023; 23(4): e110123212563.
[http://dx.doi.org/10.2174/1871526523666230111104355] [PMID: 36631923]
[19]
Fajloun Z, Abi Khattar Z, Kovacic H, Legros C, Sabatier JM. SIBO: The trail of a “new” human pathology associated with multiple severe and disabling COVID-19 and Long COVID symptoms or induced by the anti-covid-19 vaccine. Infect Disord Drug Targets 2023; 23(4): e100223213593.
[http://dx.doi.org/10.2174/1871526523666230210162334] [PMID: 36762752]
[20]
Fajloun Z, Abi Khattar Z, Kovacic H, Legros C, Sabatier JM. Anti-COVID-19 Vaccination, COVID-19, and female contraception: The exacerbated risks (thromboembolism) of the estrogen-progestin Pill. Infect Disord Drug Targets 2023; 23(4): e240223214000.
[http://dx.doi.org/10.2174/1871526523666230224094439] [PMID: 36823996]
[21]
Fajloun Z, Abi Khattar Z, Kovacic H, Legros C, Sabatier JM. Understanding and relieving of neuropathic disorders in the long COVID. Infect Disord Drug Targets 2023; 23(4): e270223214061.
[http://dx.doi.org/10.2174/1871526523666230227113205] [PMID: 36843369]
[22]
Fajloun Z, Abi Khattar Z, Kovacic H, Sabatier JM. COVID-19 and anti-COVID-19 vaccination: Potential damages to the thyroid gland. Infect Disord Drug Targets 2023; 23(6): e090523216698.
[http://dx.doi.org/10.2174/1871526523666230509112038] [PMID: 37165584]
[23]
Fajloun Z, Wu Y, Cao Z, Kovacic H, Sabatier JM. COVID-19 and alzheimer’s disease: The link finally established. Infect Disord Drug Targets 2023; 23(7): e290523217428.
[http://dx.doi.org/10.2174/1871526523666230529162633] [PMID: 37254552]
[24]
Fajloun Z, Wu Y, Cao Z, Kovacic H, Sabatier JM. COVID-19 and parkinson’s disease: The link also established! Infect Disord Drug Targets 2023; 23(8): e190623218061.
[http://dx.doi.org/10.2174/1871526523666230619104142] [PMID: 37340743]
[25]
Okamoto K, Tajima H, Nakanuma S, et al. Angiotensin II enhances epithelial-to-mesenchymal transition through the interaction between activated hepatic stellate cells and the stromal cell-derived factor-1/CXCR4 axis in intrahepatic cholangiocarcinoma. Int J Oncol 2012; 41(2): 573-82.
[http://dx.doi.org/10.3892/ijo.2012.1499] [PMID: 22664794]
[26]
Okamoto K, Tajima H, Ohta T, et al. Angiotensin II induces tumor progression and fibrosis in intrahepatic cholangiocarcinoma through an interaction with hepatic stellate cells. Int J Oncol 2010; 37(5): 1251-9.
[http://dx.doi.org/10.3892/ijo_00000776] [PMID: 20878072]

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