Abstract
Introduction: By condensing 2-aminothiazole and phenacyl bromide, a novel catalystfree synthetic approach for the synthesis of imidazo[2,1-b]thiazole derivatives has been developed.
Methods: In this work, aloe vera/water (3:2) is used as a reusable, environmentally benign, greenpromoting media to synthesize desired products. This method enables the synthesis of a diverse range of aryl-substituted imidazo[2,1-b]thiazoles.
Results: This solvent system demonstrates remarkable efficiency and offers numerous advantages, including shorter reaction times, the absence of side product formation, costeffectiveness, excellent atom efficiency, straightforward operation, and high yields.
Conclusion: In conclusion, we successfully developed a green protocol for the environmentally benign synthesis of imidazo[2,1-b]thiazole derivatives using aloe vera water as green-promoting media.
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