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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Synthesis of N1-caffeoyl-N10-dihydrocaffeoylspermidine (Scotanamine D)

Author(s): Jingwen Ji, Zafar Iqbal*, Liuyan Li, Jian Sun, Pengjuan Zhou, Lijuan Zhai, Lili He, Dong Tang, Jinbo Ji, Haikang Yang and Zhixiang Yang*

Volume 21, Issue 8, 2024

Published on: 25 January, 2024

Page: [720 - 726] Pages: 7

DOI: 10.2174/0115701786282079231229050431

Price: $65

Abstract

N1-caffeoyl-N10-dihydrocaffeoylspermidine (Scotanamine D), a spermidine alkaloid isolated from various plants, is a medicinally valuable natural product. Recent studies have pointed out several health benefits of this compound. However, its synthetic procedures are still not described in the literature. We report the synthesis of this compound following two different schemes comprising multiple steps with excellent overall yields, which are 57% and 81%, respectively. These two synthetic schemes, which use commercially available and cheaper starting materials, can facilitate the large-scale manufacturing of Scotanamine D.

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