Generic placeholder image

Recent Advances in Food, Nutrition & Agriculture

Editor-in-Chief

ISSN (Print): 2772-574X
ISSN (Online): 2772-5758

Review Article

A Systemic Review on Nutraceutical Supplements used in the Management of Osteoarthritis

Author(s): Zulfa Nooreen*, Pranay Wal and Fariha Summaiyya

Volume 15, Issue 1, 2024

Published on: 22 January, 2024

Page: [33 - 45] Pages: 13

DOI: 10.2174/012772574X270405231102054920

Price: $65

Abstract

Osteoarthritis (OA) is a progressive degenerative joint disease. It basically impairs the structural integrity of articulate cartilage and imbalances the catabolic and anabolic signals in the joint. A degenerative disease is characterized by swelling, pain, and joint stiffness. The treatment and management of osteoarthritis are based on analgesic and anti-inflammatory agents, whereas the exact cause of OA is not known yet. The negative effects of synthetic medications have led to a daily rise in the usage of nutraceuticals and dietary supplements. Clinicians are aware of these treatments, and they also recommend nutraceuticals in addition to the currently preferred therapy. Many in-vitro and in-vivo experiments have been performed in past years to evaluate the function of these on osteoarthritis.

The collection of articles was published on search engines like PubMed, Scopus, Google Scholar, ResearchGate, and ScienceDirect. The evaluation covers every potential nutraceutical utilized in osteoarthritis, together with its supporting data and mode of action.

The present review discusses nutraceuticals, including devil’s claw, vitamin D, boswellic acid, capsaicin, ginger, curcumin, krill oil, ginger, and avocado/soybean unsaponifiable.

Graphical Abstract

[1]
Musumeci G, Aiello F, Szychlinska M, Di Rosa M, Castrogiovanni P, Mobasheri A. Osteoarthritis in the XXIst century: Risk factors and behaviours that influence disease onset and progression. Int J Mol Sci 2015; 16(12): 6093-112.
[http://dx.doi.org/10.3390/ijms16036093] [PMID: 25785564]
[2]
Musumeci G. Effects of exercise on physical limitations and fatigue in rheumatic diseases. World J Orthop 2015; 6(10): 762-9.
[http://dx.doi.org/10.5312/wjo.v6.i10.762] [PMID: 26601057]
[3]
Reynard LN, Loughlin J. Genetics and epigenetics of osteoarthritis. Maturitas 2012; 71(3): 200-4.
[http://dx.doi.org/10.1016/j.maturitas.2011.12.001] [PMID: 22209350]
[4]
Brandt KD, Dieppe P, Radin EL. Etiopathogenesis of Osteoarthritis. Rheum Dis Clin North Am 2008; 34(3): 531-59.
[http://dx.doi.org/10.1016/j.rdc.2008.05.011] [PMID: 18687271]
[5]
Lorenz H, Richter W. Osteoarthritis: Cellular and molecular changes in degenerating cartilage. Prog Histochem Cytochem 2006; 40(3): 135-63.
[http://dx.doi.org/10.1016/j.proghi.2006.02.003] [PMID: 16759941]
[6]
Martel-Pelletier J, Pelletier JP. Is osteoarthritis a disease involving only cartilage or other articular tissues? Eklem Hastalik Cerrahisi 2010; 21(1): 2-14.
[PMID: 20302555]
[7]
Nordenvall R, Bahmanyar S, Adami J, Stenros C, Wredmark T, Felländer-Tsai L. A population-based nationwide study of cruciate ligament injury in Sweden, 2001-2009: Incidence, treatment, and sex differences. Am J Sports Med 2012; 40(8): 1808-13.
[http://dx.doi.org/10.1177/0363546512449306] [PMID: 22684536]
[8]
Palthur MP, Sajala Palthur SS, Chitta SK. Nutraceuticals: Concept and Regulatory Scenario. Int J Pharm Pharm Sci 2010; 2: 14-20.
[9]
AlAli M, Alqubaisy M, Aljaafari MN, et al. Nutraceuticals: Transformation of conventional foods into health promoters/disease preventers and safety considerations. Molecules 2021; 26(9): 2540.
[http://dx.doi.org/10.3390/molecules26092540] [PMID: 33925346]
[10]
Nasri H, Ardalan MR, Rafieian-Kopaei M. On the occasion of world hypertension day 2014: A nephrology point of view. J Res Med Sci 2014; 19(9): 911.
[11]
Gharipour M, Ramezani MA, Sadeghi M, et al. Sex based levels of C-reactive protein and white blood cell count in subjects with metabolic syndrome: Isfahan Healthy Heart Program. J Res Med Sci 2013; 18(6): 467.
[12]
Mankin HJ, Dorfman H, Lippiello L, Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 1971; 53(3): 523-37.
[http://dx.doi.org/10.2106/00004623-197153030-00009] [PMID: 5580011]
[13]
Norn S, Permin H, Kruse PR, Kruse E. [From willow bark to acetylsalicylic acid]. Dan Medicinhist Arbog 2009; 37: 79-98.
[PMID: 20509453]
[14]
Valsamidou E, Amerikanou C, Tzavara C, et al. Nutraceuticals for knee osteoarthritis pain relief. results from a preliminary randomised clinical trial. Dietetics 2021; 1(1): 2-14.
[http://dx.doi.org/10.3390/dietetics1010002]
[15]
Awwad GEH LM, Awwad GE, Bradshaw AR. A review of nutraceuticals in joint arthritis. J Pain Relief 2015; 4(3)
[http://dx.doi.org/10.4172/2167-0846.1000180]
[16]
Boote DN, Beile P. Scholars before researchers: On the centrality of the dissertation literature review in research preparation. Educ Res 2005; 34(6): 3-15.
[17]
Reza Samadzadeh G, Rigi T, Reza Ganjali A. Comparison of Four Search Engines and their efficacy With Emphasis on Literature Research in Addiction (Prevention and Treatment). Int J High Risk Behav Addict 2013; 1(4): 166-71.
[http://dx.doi.org/10.5812/ijhrba.6551] [PMID: 24971257]
[18]
Anders ME, Evans DP. Comparison of PubMed and Google Scholar literature searches. Respir Care 2010; 55(5): 578-83.
[PMID: 20420728]
[19]
What is Science Direct? 2012. Available From: www.cityu.edu.hk/lib/instruct/guides/eresguid/sd.pdf
[20]
Falagas ME, Pitsouni EI, Malietzis GA, Pappas G. Comparison of PubMed, Scopus, Web of Science, and Google Scholar: Strengths and weaknesses. FASEB J 2008; 22(2): 338-42.
[http://dx.doi.org/10.1096/fj.07-9492LSF] [PMID: 17884971]
[21]
Ekram R, Nazer MS. Hospital Admission Profile Due to Osteoarthritis: An Ecological Study. Cureus 2023; 15(5): e38435.
[http://dx.doi.org/10.7759/cureus.38435] [PMID: 37273367]
[22]
Srikanth VK, Fryer JL, Zhai G, Winzenberg TM, Hosmer D, Jones G. A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis. Osteoarthritis Cartilage 2005; 13(9): 769-81.
[http://dx.doi.org/10.1016/j.joca.2005.04.014] [PMID: 15978850]
[23]
Musumeci G, Loreto C, Imbesi R, et al. Advantages of exercise in rehabilitation, treatment and prevention of altered morphological features in knee osteoarthritis. A narrative review. Histol Histopathol 2014; 29(6): 707-19.
[24]
Theiler R, Sangha O, Schaeren S, et al. Superior responsiveness of the pain and function sections of WOMAC Index as compared to the Lequesne-algofunctional Index in patients with osteoarthritis of the lower extremities. Osteoarthritis Cartilage 1999; 515-9.
[http://dx.doi.org/10.1053/joca.1999.0262] [PMID: 10558848]
[25]
Musumeci G, Castrogiovanni P, Trovato FM, Di G, Loreto C, Castorina S. Microscopic and macroscopic anatomical features in healthy and osteoarthritic knee cartilage. OA Anatomy 2013; 1(3): 30.
[http://dx.doi.org/10.13172/2052-7829-1-3-898]
[26]
Ruan MZC, Patel RM, Dawson BC, Jiang MM, Lee BHL. Pain, motor and gait assessment of murine osteoarthritis in a cruciate ligament transection model. Osteoarthritis Cartilage 2013; 21(9): 1355-64.
[http://dx.doi.org/10.1016/j.joca.2013.06.016] [PMID: 23973150]
[27]
Castrogiovanni P, Trovato F, Loreto C, Nsir H, Szychlinska M, Musumeci G. Nutraceutical supplements in the management and prevention of osteoarthritis. Int J Mol Sci 2016; 17(12): 2042.
[http://dx.doi.org/10.3390/ijms17122042] [PMID: 27929434]
[28]
Egloff C, Hügle T, Valderrabano V. Biomechanics and pathomechanisms of osteoarthritis. Swiss Med Wkly 2012; 142(2930): w13583.
[PMID: 22815119]
[29]
Roos H, Adalberth T, Dahlberg L, Lohmander LS. Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: The influence of time and age. Osteoarthritis Cartilage 1995; 3(4): 261-7.
[http://dx.doi.org/10.1016/S1063-4584(05)80017-2] [PMID: 8689461]
[30]
Sartori-Cintra AR, Aikawa P, Cintra DE. Obesity versus osteoarthritis: Beyond the mechanical overload. Einstein (Sao Paulo) 2014; 12(3): 374-9.
[http://dx.doi.org/10.1590/s1679-45082014rb2912] [PMID: 25184806]
[31]
Khan IM, Redman SN, Williams R, Dowthwaite GP, Oldfield SF, Archer CW. The development of synovial joints. Curr Top Dev Biol 2007; 79: 1-36.
[http://dx.doi.org/10.1016/S0070-2153(06)79001-9] [PMID: 17498545]
[32]
Adams ME, Lussier AJ, Peyron JG. A risk-benefit assessment of injections of hyaluronan and its derivatives in the treatment of osteoarthritis of the knee. Drug Saf 2000; 23(2): 115-30.
[http://dx.doi.org/10.2165/00002018-200023020-00003] [PMID: 10945374]
[33]
Felson DT. Osteoarthritis of the Knee. N Engl J Med 2006; 354(8): 841-8.
[http://dx.doi.org/10.1056/NEJMcp051726] [PMID: 16495396]
[34]
Man GS, Mologhianu G. Osteoarthritis pathogenesis - a complex process that involves the entire joint. J Med Life 2014; 7(1): 37-41.
[PMID: 24653755]
[35]
Musumeci G, Trovato FM, Pichler K, Weinberg AM, Loreto C, Castrogiovanni P. Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: An in vivo and in vitro study on lubricin expression. J Nutr Biochem 2013; 24(12): 2064-75.
[http://dx.doi.org/10.1016/j.jnutbio.2013.07.007] [PMID: 24369033]
[36]
Maldonado M, Nam J. The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis. BioMed Res Int 2013; 2013: 1-10.
[http://dx.doi.org/10.1155/2013/284873] [PMID: 24069595]
[37]
Yunus MHM, Nordin A, Kamal H. Pathophysiological perspective of osteoarthritis. Medicina (Kaunas) 2020; 56(11): 614.
[http://dx.doi.org/10.3390/medicina56110614] [PMID: 33207632]
[38]
Nagaosa Y, Lanyon P, Doherty M. Characterisation of size and direction of osteophyte in knee osteoarthritis: A radiographic study. Ann Rheum Dis 2002; 61(4): 319-24.
[http://dx.doi.org/10.1136/ard.61.4.319] [PMID: 11874834]
[39]
Hunter DJ, McDougall JJ, Keefe FJ. The symptoms of osteoarthritis and the genesis of pain. Rheum Dis Clin North Am 2008; 34(3): 623-43.
[http://dx.doi.org/10.1016/j.rdc.2008.05.004] [PMID: 18687276]
[40]
Orange DE, Blachere NE, DiCarlo EF, et al. Rheumatoid arthritis morning stiffness is associated with synovial fibrin and neutrophils. Arthritis Rheumatol 2020; 72(4): 557-64.
[http://dx.doi.org/10.1002/art.41141] [PMID: 31612614]
[41]
Heidari B. Knee osteoarthritis prevalence, risk factors, pathogenesis and features: Part I. Caspian J Intern Med 2011; 2(2): 205-12.
[PMID: 24024017]
[42]
Shakibaei M, Mobasheri A, Buhrmann C. Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro. Genes Nutr 2011; 6(2): 171-9.
[http://dx.doi.org/10.1007/s12263-010-0179-5] [PMID: 21484156]
[43]
Abhishek A, Doherty M. Diagnosis and clinical presentation of osteoarthritis. Rheum Dis Clin North Am 2013; 39(1): 45-66.
[http://dx.doi.org/10.1016/j.rdc.2012.10.007] [PMID: 23312410]
[44]
Lawand NB, McNearney T, Westlund KN. Amino acid release into the knee joint: Key role in nociception and inflammation. Pain 2000; 86(1): 69-74.
[http://dx.doi.org/10.1016/S0304-3959(99)00311-5] [PMID: 10779662]
[45]
Bagge E, Bjelle A, Edén S, Svanborg A. A longitudinal study of the occurrence of joint complaints in elderly people. Age Ageing 1992; 21(3): 160-7.
[http://dx.doi.org/10.1093/ageing/21.3.160] [PMID: 1615775]
[46]
Felson DT, Anderson JJ, Naimark A, Kannel W, Meenan RF. The prevalence of chondrocalcinosis in the elderly and its association with knee osteoarthritis: The Framingham Study. J Rheumatol 1989; 16(9): 1241-5.
[PMID: 2810282]
[47]
Guermazi A, Zaim S, Taouli B, Miaux Y, Peterfy CG, Genant HK. MR findings in knee osteoarthritis. Eur Radiol 2003; 13(6): 1370-86.
[http://dx.doi.org/10.1007/s00330-002-1554-4] [PMID: 12764655]
[48]
Crema MD, Roemer FW, Marra MD, Guermazi A. Magnetic resonance imaging assessment of subchondral bone and soft tissues in knee osteoarthritis. Rheum Dis Clin North Am 2009; 35(3): 557-77.
[http://dx.doi.org/10.1016/j.rdc.2009.08.003] [PMID: 19931803]
[49]
Conaghan PG, Felson DT. Structural associations of osteoarthritis pain: Lessons from magnetic resonance imaging.Osteoarthritic Joint Pain: Novartis Foundation Symposium 260. Hoboken, New Jersey: Wiley 2004.
[http://dx.doi.org/10.1002/0470867639.ch13]
[50]
Roemer FW, Eckstein F, Guermazi A. Magnetic resonance imaging-based semiquantitative and quantitative assessment in osteoarthritis. Rheum Dis Clin North Am 2009; 35(3): 521-55.
[http://dx.doi.org/10.1016/j.rdc.2009.08.006] [PMID: 19931802]
[51]
Podlipská J, Guermazi A, Lehenkari P, et al. Comparison of diagnostic performance of semi-quantitative knee ultrasound and knee radiography with MRI: Oulu knee osteoarthritis study. Sci Rep 2016; 6(1): 22365.
[http://dx.doi.org/10.1038/srep22365] [PMID: 26926836]
[52]
Chinese Orthopaedic Association. Diagnosis and treatment of osteoarthritis. Orthop Surg 2010; 2(1): 1-6.
[http://dx.doi.org/10.1111/j.1757-7861.2009.00055.x] [PMID: 22009900]
[53]
Arian CJ, Michael D, Br J. The treatment of osteoarthritis. clin. Pharmac 1992; 33: 357-63.
[54]
Singh G, Fort JG, Goldstein JL, et al. Celecoxib versus naproxen and diclofenac in osteoarthritis patients: SUCCESS-I Study. Am J Med 2006; 119(3): 255-66.
[http://dx.doi.org/10.1016/j.amjmed.2005.09.054] [PMID: 16490472]
[55]
Wiesenhutter CW, Boice JA, Ko A, et al. Evaluation of the comparative efficacy of etoricoxib and ibuprofen for treatment of patients with osteoarthritis: A randomized, double-blind, placebo-controlled trial. Mayo Clin Proc 2005; 80(4): 470-9.
[http://dx.doi.org/10.4065/80.4.470] [PMID: 15819283]
[56]
Primorac D, Molnar V, Matišić V. et al. Comprehensive review of knee osteoarthritis pharmacological treatment and the latest professional societies’ guidelines. Pharmaceuticals (Basel) 2021; 14(3): 205.
[http://dx.doi.org/10.3390/ph14030205] [PMID: 33801304]
[57]
Hafez AR, Alenazi AM, Kachanathu SJ, Alroumi AM, Mohamed ES. Knee Osteoarthritis: A Review of Literature. Phys Med Rehabil Int 2014; 1(5): 8.
[58]
Primorac D, Molnar V, Rod E, et al. Knee osteoarthritis: A review of pathogenesis and state-of-the-art non-operative therapeutic considerations. Genes (Basel) 2020; 11(8): 854.
[http://dx.doi.org/10.3390/genes11080854] [PMID: 32722615]
[59]
D’Adamo S, Cetrullo S, Panichi V, Mariani E, Flamigni F, Borzì RM. Nutraceutical activity in osteoarthritis biology: A focus on the nutrigenomic role. Cells 2020; 9(5): 1232.
[http://dx.doi.org/10.3390/cells9051232] [PMID: 32429348]
[60]
Godkar PB, Gordon RK, Ravindran A, Doctor BP. Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate-induced injury in embryonic rat forebrain neuronal cells. Phytomedicine 2006; 13(1-2): 29-36.
[http://dx.doi.org/10.1016/j.phymed.2003.11.011] [PMID: 16360930]
[61]
Zhang Z, Leong DJ, Xu L, et al. Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model. Arthritis Res Ther 2016; 18(1): 128.
[http://dx.doi.org/10.1186/s13075-016-1025-y] [PMID: 27260322]
[62]
Henrotin Y, Clutterbuck AL, Allaway D, et al. Biological actions of curcumin on articular chondrocytes. Osteoarthritis Cartilage 2010; 18(2): 141-9.
[http://dx.doi.org/10.1016/j.joca.2009.10.002] [PMID: 19836480]
[63]
Virk RS, Rehman MAU, Munawar MA, et al. Curcumincontaining orthopedic implant coatings deposited on poly-etherether-ketone/bioactive glass/hexagonal boron nitride layers by electrophoretic deposition. Coatings 2019; 9(9): 572.
[http://dx.doi.org/10.3390/coatings9090572]
[64]
Murugan S, Bethapudi B, Purusothaman D, Chandrasekaran PR, Velusami CC. Antiarthritic effect of polar extract of Curcuma longa on monosodium iodoacetate induced osteoarthritis in rats. Antiinflamm Antiallergy Agents Med Chem 2017; 16(3): 193-202.
[65]
Paultre K, Cade W, Hernandez D, Reynolds J, Greif D, Best TM. Therapeutic effects of turmeric or curcumin extract on pain and function for individuals with knee osteoarthritis: A systematic review. BMJ Open Sport Exerc Med 2021; 7(1): e000935.
[http://dx.doi.org/10.1136/bmjsem-2020-000935] [PMID: 33500785]
[66]
Hsiao AF, Lien YC, Tzeng IS, Liu CT, Chou SH, Horng YS. The efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic review and meta-analysis. Complement Ther Med 2021; 63: 102775.
[http://dx.doi.org/10.1016/j.ctim.2021.102775] [PMID: 34537344]
[67]
Muhammad ZA, Ahmad T. Therapeutic uses of pineappleextracted bromelain in surgical care - A review. J Pak Med Assoc 2017; 67(1): 121-5.
[PMID: 28065968]
[68]
Walker AF, Bundy R, Hicks SM, Middleton RW. Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine 2002; 9(8): 681-6.
[http://dx.doi.org/10.1078/094471102321621269] [PMID: 12587686]
[69]
Brien S, Lewith G, Walker AF, Middleton R, Prescott P, Bundy R. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: A randomized placebo-controlled pilot study. QJM 2006; 99(12): 841-50.
[http://dx.doi.org/10.1093/qjmed/hcl118] [PMID: 17121765]
[70]
Brien S, Lewith G, Walker A, Hicks SM, Middleton D. Bromelain as a treatment for osteoarthritis: A review of clinical studies. Evid Based Complement Alternat Med 2004; 1(3): 251-7.
[http://dx.doi.org/10.1093/ecam/neh035] [PMID: 15841258]
[71]
Nayak SK. Nutraceuticals as supplements in the management of arthritis: A review. Int J Pharmaceut Res 2023; 15(3): 1-15.
[http://dx.doi.org/10.31838/ijpr/2021.13.01.074]
[72]
Funk JL, Frye JB, Oyarzo JN, Timmermann BN. Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis. J Nat Prod 2009; 72(3): 403-7.
[http://dx.doi.org/10.1021/np8006183] [PMID: 19216559]
[73]
Haghighi M, Khalvat A, Toliat T, Jallaei SH. Comparing the effects of ginger (Zingiber officinale) extract and ibuprofen on patients with osteoarthritis. Arch Iran Med 2005; 8(4): 267-71.
[74]
Hosseinzadeh A, Bahrampour Juybari K, Fatemi MJ, et al. Protective effect of ginger (Zingiber officinale roscoe) extract against oxidative stress and mitochondrial apoptosis induced by interleukin-1β in cultured chondrocytes. Cells Tissues Organs 2017; 204(5-6): 241-50.
[http://dx.doi.org/10.1159/000479789] [PMID: 28877520]
[75]
Kravchenko I, Eberle L, Nesterkina M, Kobernik A. Anti-inflammatory and analgesic activity of ointment based on dense ginger extract (Zingiber officinale). Journal of Herbmed Pharmacology 2019; 8(2): 126-32.
[http://dx.doi.org/10.15171/jhp.2019.20]
[76]
Viswanath J, Cheekavolu C, Sankaraiah S, Dixit R. Effect of cissus quadrangularis linn and zingiber officinale rosc in osteoarthritis patients. International Journal of Research in Medical Sciences 2017; 5(8): 3540.
[http://dx.doi.org/10.18203/2320-6012.ijrms20173558]
[77]
Hwang JH, Jung HW, Oh SY, Kang JS, Kim JP, Park YK. Effects of Zingiber officinale extract on collagen-induced arthritis in mice and IL-1β-induced inflammation in human synovial fibroblasts. Eur J Inflamm 2017; 15(3): 168-78.
[http://dx.doi.org/10.1177/1721727X17727997]
[78]
Akhtar N, Haqqi TM. Current nutraceuticals in the management of osteoarthritis: A review. Ther Adv Musculoskelet Dis 2012; 4(3): 181-207.
[http://dx.doi.org/10.1177/1759720X11436238] [PMID: 22850529]
[79]
Belcaro G, Cesarone MR, Errichi S, et al. Treatment of osteoarthritis with Pycnogenol®. The SVOS (San Valentino osteo-arthrosis study). evaluation of signs, symptoms, physical performance and vascular aspects. Phytother Res 2008; 22(4): 518-23.
[http://dx.doi.org/10.1002/ptr.2376] [PMID: 18386255]
[80]
Zhu X, Sang L, Wu D, Rong J, Jiang L. Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: A meta-analysis of randomized controlled trials. J Orthop Surg Res 2018; 13(1): 170.
[http://dx.doi.org/10.1186/s13018-018-0871-5] [PMID: 29980200]
[81]
Duc HN, Oh H, Kim MS. Effects of antioxidant vitamins, curry consumption, and heavy metal levels on metabolic syndrome with comorbidities: A Korean community-based cross-sectional study. Antioxidants 2021; 10(5): 808.
[http://dx.doi.org/10.3390/antiox10050808] [PMID: 34069726]
[82]
Takuma M, Haruka K, Mutsuto W, et al. Olive leaf extract prevents cartilage degeneration in osteoarthritis of STR/ort mice. Biosci Biotechnol Biochem 2018; 82(7): 1101-6.
[http://dx.doi.org/10.1080/09168451.2018.1451741] [PMID: 29587623]
[83]
Heydari Nasrabadi M, Parsivand M, Mohammadi N, Asghari Moghaddam N. Comparison of Elaeagnus angustifolia L. extract and quercetin on mouse model of knee osteoarthritis. J Ayurveda Integr Med 2022; 13(2): 100529.
[http://dx.doi.org/10.1016/j.jaim.2021.10.001] [PMID: 34862093]
[84]
Chu C, Deng J, Man Y, Qu Y. Green tea extracts epigallocatechin-3-gallate for different treatments. BioMed Res Int 2017; 2017: 1-9.
[http://dx.doi.org/10.1155/2017/5615647] [PMID: 28884125]
[85]
Nadeem M, Imran M, Aslam Gondal T, et al. Therapeutic potential of rosmarinic acid: A comprehensive review. Appl Sci (Basel) 2019; 9(15): 3139.
[http://dx.doi.org/10.3390/app9153139]
[86]
Liu FC, Wang CC, Lu JW, et al. Chondroprotective effects of genistein against osteoarthritis induced joint inflammation. Nutrients 2019; 11(5): 1180.
[http://dx.doi.org/10.3390/nu11051180] [PMID: 31137797]
[87]
Rizvi W, Fayazuddin M, Shariq S, et al. Anti-inflammatory activity of roots of Cichorium intybus due to its inhibitory effect on various cytokines and antioxidant activity. Anc Sci Life 2014; 34(1): 44-9.
[http://dx.doi.org/10.4103/0257-7941.150780] [PMID: 25737610]
[88]
Cavin C, Delannoy M, Malnoe A, et al. Inhibition of the expression and activity of cyclooxygenase-2 by chicory extract. Biochem Biophys Res Commun 2005; 327(3): 742-9.
[http://dx.doi.org/10.1016/j.bbrc.2004.12.061] [PMID: 15649409]
[89]
Kromer TO, de Bie RA, Bastiaenen CHG. Effectiveness of individualized physiotherapy on pain and functioning compared to a standard exercise protocol in patients presenting with clinical signs of subacromial impingement syndrome. A randomized controlled trial. BMC Musculoskelet Disord 2010; 11(1): 114.
[http://dx.doi.org/10.1186/1471-2474-11-114] [PMID: 20534140]
[90]
Ripoll C, Schmidt BM, Ilic N, et al. Anti-inflammatory effects of a sesquiterpene lactone extract from chicory (Cichorium intybus L.) roots. Nat Prod Commun 2007; 2(7)
[91]
Bayazid AB, Park SH, Kim JG, Lim BO. Green chicory leaf extract exerts anti-inflammatory effects through suppressing LPS-induced MAPK/NF-κB activation and hepatoprotective activity in vitro. Food Agric Immunol 2020; 31(1): 513-32.
[http://dx.doi.org/10.1080/09540105.2020.1742667]
[92]
Itkonen S, Erkkola M, Lamberg-Allardt C. Vitamin D fortification of fluid milk products and their contribution to vitamin D intake and vitamin D status in observational studies:a review. Nutrients 2018; 10(8): 1054.
[http://dx.doi.org/10.3390/nu10081054] [PMID: 30096919]
[93]
Sahay M, Sahay R. Rickets-vitamin D deficiency and dependency. Indian J Endocrinol Metab 2012; 16(2): 164-76.
[http://dx.doi.org/10.4103/2230-8210.93732] [PMID: 22470851]
[94]
Khazai N, Judd SE, Tangpricha V. Calcium and vitamin D: Skeletal and extraskeletal health. Curr Rheumatol Rep 2008; 10(2): 110-7.
[http://dx.doi.org/10.1007/s11926-008-0020-y] [PMID: 18460265]
[95]
Park CY. Vitamin D in the prevention and treatment of osteoarthritis: From clinical interventions to cellular evidence. Nutrients 2019; 11(2): 243.
[http://dx.doi.org/10.3390/nu11020243] [PMID: 30678273]
[96]
Corrado A, Neve A, Macchiarola A, Gaudio A, Marucci A, Cantatore FP. RANKL/OPG ratio and DKK-1 expression in primary osteoblastic cultures from osteoarthritic and osteoporotic subjects. J Rheumatol 2013; 40(5): 684-94.
[http://dx.doi.org/10.3899/jrheum.120845] [PMID: 23457386]
[97]
Burr DB, Gallant MA. Bone remodelling in osteoarthritis. Nat Rev Rheumatol 2012; 8(11): 665-73.
[http://dx.doi.org/10.1038/nrrheum.2012.130] [PMID: 22868925]
[98]
Siddiqui MZ. Boswellia serrata, a potential antiinflammatory agent: An overview. Indian J Pharm Sci 2011; 73(3): 255-61.
[http://dx.doi.org/10.4103/0250-474X.93507] [PMID: 22457547]
[99]
Yu G, Xiang W, Zhang T, Zeng L, Yang K, Li J. Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: Asystematic review and meta-analysis. BMC Complement Med Ther 2020; 20(1): 225.
[http://dx.doi.org/10.1186/s12906-020-02985-6]
[100]
Singh GB, Atal CK. Pharmacology of an extract of salai guggal ex-Boswellia serrata, a new non-steroidal anti-inflammatory agent. Agents Actions 1986; 18(3-4): 407-12.
[http://dx.doi.org/10.1007/BF01965005] [PMID: 3751752]
[101]
Basch E, Boon H, Heerema TD, et al. Boswellia. J Herb Pharmacother 2004; 4(3): 63-83.
[http://dx.doi.org/10.1080/J157v04n03_06] [PMID: 15829470]
[102]
Majeed M, Nagabhushanam K, Lawrence L, Nallathambi R, Thiyagarajan V, Mundkur L. Boswellia serrata extract containing 30% 3-acetyl-11-keto-boswellic acid attenuates inflammatory mediators and preserves extracellular matrix in collagen-induced arthritis. Front Physiol 2021; 12: 735247.
[http://dx.doi.org/10.3389/fphys.2021.735247] [PMID: 34650445]
[103]
Razavi SZ, Karimi M, Kamalinejad M. The efficacy of topical oliban oil (Boswellia Carterii B.) in relieving the symptoms of knee osteoarthritis. JPMRE 2019; 1(1): 7-13.
[104]
Mariano A, Bigioni I, Mattioli R, et al. Harpagophytum procumbens root extract mediates anti-inflammatory effects in osteoarthritis synoviocytes through CB2 Activation. Pharmaceuticals (Basel) 2022; 15(4): 457.
[http://dx.doi.org/10.3390/ph15040457] [PMID: 35455454]
[105]
Fiebich BL, Muñoz E, Rose T, Weiss G, McGregor GP. Molecular targets of the antiinflammatory Harpagophytum procumbens (devil’s claw): Inhibition of TNFα and COX-2 gene expression by preventing activation of AP-1. Phytother Res 2012; 26(6): 806-11.
[http://dx.doi.org/10.1002/ptr.3636] [PMID: 22072539]
[106]
Chantre P, Cappelaere A, Leblan D, Guedon D, Vandermander J, Fournie B. Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine 2000; 7(3): 177-83.
[http://dx.doi.org/10.1016/S0944-7113(00)80001-X] [PMID: 11185727]
[107]
Gagnier JJ, Chrubasik S, Manheimer E. Harpgophytum procumbens for osteoarthritis and low back pain: A systematic review. BMC Complement Altern Med 2004; 4(1): 13.
[http://dx.doi.org/10.1186/1472-6882-4-13] [PMID: 15369596]
[108]
Inaba K, Murata K, Naruto S, Matsuda H. Inhibitory effects of devil’s claw (secondary root of Harpagophytum procumbens) extract and harpagoside on cytokine production in mouse macrophages. J Nat Med 2010; 64(2): 219-22.
[http://dx.doi.org/10.1007/s11418-010-0395-8] [PMID: 20177800]
[109]
Loew D, Möllerfeld J, Schrödter A, Puttkammer S, Kaszkin M. Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo. Clin Pharmacol Ther 2001; 69(5): 356-64.
[http://dx.doi.org/10.1067/mcp.2001.115445] [PMID: 11372004]
[110]
Fiebich BL, Fiebich BL, Heinrich M, Hiller KO, Kammerer N. Inhibition of TNF-α synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap 69. Phytomedicine 2001; 8(1): 28-30.
[http://dx.doi.org/10.1078/0944-7113-00002] [PMID: 11292236]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy