Abstract
MiRNAs are confirmed to be a kind of short and eminently conserved noncoding RNAs, which regulate gene expression at the post-transcriptional level via binding to the 3'- untranslated region (3’-UTR) of targeting multiple target messenger RNAs. Recently, growing evidence stresses the point that they play a crucial role in a variety of pathological processes, including human cancers. Dysregulated miRNAs act as oncogenes or tumor suppressor genes in many cancer types. Among them, we noticed that miR-122 has been widely reported to significantly influence carcinogenicity in a variety of tumors by regulating target genes and signaling pathways. Here, we focused on the expression of miR-122 in regulatory mechanisms and tumor biological processes. We also discussed the effects of miR-122 dysregulation in various types of human malignancies and the potential to develop new molecular miR-122-targeted therapies. The present review suggests that miR-122 may be a potentially useful cancer diagnosis and treatment biomarker. More clinical diagnoses need to be further launched in the future. A promising direction to improve the outcomes for cancer patients will likely combine miR-122 with other traditional tumor biomarkers.
Graphical Abstract
[http://dx.doi.org/10.2147/OTT.S183600] [PMID: 30410367]
[http://dx.doi.org/10.1016/S0092-8674(04)00045-5] [PMID: 14744438]
[http://dx.doi.org/10.1186/1476-4598-11-56] [PMID: 22900969]
[http://dx.doi.org/10.1016/j.febslet.2013.12.028] [PMID: 24440352]
[http://dx.doi.org/10.1016/j.febslet.2011.03.039] [PMID: 21439283]
[http://dx.doi.org/10.1016/S0960-9822(02)00809-6] [PMID: 12007417]
[http://dx.doi.org/10.4161/rna.1.2.1066] [PMID: 17179747]
[http://dx.doi.org/10.1172/JCI63539] [PMID: 22820288]
[http://dx.doi.org/10.1172/JCI63455] [PMID: 22820290]
[http://dx.doi.org/10.1126/science.1114519] [PMID: 15919954]
[http://dx.doi.org/10.1101/gad.1781009] [PMID: 19487572]
[http://dx.doi.org/10.1002/hep.23818] [PMID: 20842632]
[http://dx.doi.org/10.1038/nsmb.2982] [PMID: 25730776]
[PMID: 28337380]
[http://dx.doi.org/10.1002/ijc.30433] [PMID: 27632639]
[http://dx.doi.org/10.1186/s12935-019-0922-y] [PMID: 31384177]
[http://dx.doi.org/10.1371/journal.pone.0047053] [PMID: 23056576]
[PMID: 26604787]
[PMID: 27508026]
[http://dx.doi.org/10.1016/j.cell.2011.03.019] [PMID: 21458665]
[http://dx.doi.org/10.1002/hep.29086] [PMID: 28130846]
[http://dx.doi.org/10.1038/onc.2009.211] [PMID: 19617899]
[http://dx.doi.org/10.1016/j.canlet.2011.06.027] [PMID: 21802841]
[http://dx.doi.org/10.1074/jbc.M109.016774] [PMID: 19726678]
[http://dx.doi.org/10.1158/0008-5472.CAN-08-4797] [PMID: 19584283]
[http://dx.doi.org/10.1371/journal.pone.0027740] [PMID: 22140464]
[http://dx.doi.org/10.1007/s00535-014-0932-4] [PMID: 24531873]
[http://dx.doi.org/10.1016/j.ebiom.2018.08.055] [PMID: 30195653]
[http://dx.doi.org/10.3390/jcm8020171] [PMID: 30717317]
[http://dx.doi.org/10.1016/j.yexmp.2018.10.009] [PMID: 30539797]
[http://dx.doi.org/10.1038/s41598-019-50594-2] [PMID: 31611609]
[http://dx.doi.org/10.1016/j.yexcr.2017.09.010] [PMID: 28890291]
[http://dx.doi.org/10.1371/journal.pone.0152090] [PMID: 27138141]
[http://dx.doi.org/10.3322/caac.21166] [PMID: 23335087]
[http://dx.doi.org/10.1200/JCO.2005.05.2308] [PMID: 16682732]
[http://dx.doi.org/10.3748/wjg.v20.i7.1635] [PMID: 24587643]
[http://dx.doi.org/10.3892/or.2014.3004] [PMID: 24481716]
[http://dx.doi.org/10.1016/j.biopha.2017.10.066] [PMID: 29091895]
[http://dx.doi.org/10.1093/abbs/gmz141] [PMID: 31828293]
[http://dx.doi.org/10.1177/1724600821990677] [PMID: 33752480]
[http://dx.doi.org/10.1002/jcp.28812] [PMID: 31152437]
[http://dx.doi.org/10.1002/ijc.29210] [PMID: 25220842]
[http://dx.doi.org/10.1002/ijc.30812] [PMID: 28567967]
[http://dx.doi.org/10.1177/1533033819871300] [PMID: 31564215]
[http://dx.doi.org/10.7150/jca.33022] [PMID: 31942186]
[http://dx.doi.org/10.1159/000495832] [PMID: 30522111]
[http://dx.doi.org/10.1186/s40364-017-0087-6] [PMID: 28239461]
[http://dx.doi.org/10.1186/s12957-021-02232-3] [PMID: 33865422]
[http://dx.doi.org/10.3322/caac.21254] [PMID: 25559415]
[http://dx.doi.org/10.1038/srep45411] [PMID: 28345619]
[http://dx.doi.org/10.4149/neo_2014_082] [PMID: 25150312]
[http://dx.doi.org/10.1007/s11033-019-04727-5] [PMID: 30835039]
[http://dx.doi.org/10.1002/jcb.28910] [PMID: 31155753]
[http://dx.doi.org/10.1002/1878-0261.12483] [PMID: 30938061]
[http://dx.doi.org/10.1038/ncb3094] [PMID: 25621950]
[http://dx.doi.org/10.3322/caac.20121] [PMID: 21685461]
[http://dx.doi.org/10.3390/ijms160922137] [PMID: 26389880]
[http://dx.doi.org/10.1038/s41417-018-0050-1] [PMID: 30341415]
[http://dx.doi.org/10.1016/S0140-6736(16)31678-6] [PMID: 27733282]
[http://dx.doi.org/10.1002/ijc.25516] [PMID: 21351269]
[http://dx.doi.org/10.1111/j.1349-7006.2008.00735.x] [PMID: 18377416]
[http://dx.doi.org/10.3892/ol.2018.9118] [PMID: 30127997]
[http://dx.doi.org/10.3322/caac.21208] [PMID: 24399786]
[http://dx.doi.org/10.1102/1470-7330.2013.9035] [PMID: 24061106]
[http://dx.doi.org/10.1177/1010428317691184] [PMID: 28231730]
[http://dx.doi.org/10.1002/ijc.31050] [PMID: 28921581]
[http://dx.doi.org/10.7314/APJCP.2013.14.9.5017] [PMID: 24175769]
[http://dx.doi.org/10.3892/ijo.2019.4694] [PMID: 30483771]
[http://dx.doi.org/10.3892/ijo.2017.4016] [PMID: 28534944]
[http://dx.doi.org/10.3322/caac.20107] [PMID: 21296855]
[http://dx.doi.org/10.1002/cbin.11052] [PMID: 30136751]
[http://dx.doi.org/10.3322/caac.21492] [PMID: 30207593]
[http://dx.doi.org/10.1177/1352458515581438] [PMID: 25921047]
[http://dx.doi.org/10.1200/JCO.2016.67.9613] [PMID: 27573661]
[http://dx.doi.org/10.1016/j.bbrc.2019.04.102] [PMID: 31023531]
[PMID: 24634588]
[PMID: 25392833]
[PMID: 26546436]
[http://dx.doi.org/10.1056/NEJMra0708126] [PMID: 18669428]
[PMID: 30070328]
[http://dx.doi.org/10.1007/s10072-017-2912-y] [PMID: 28367610]
[http://dx.doi.org/10.1007/s13277-014-2089-4] [PMID: 24863942]
[http://dx.doi.org/10.1038/bjc.2017.357] [PMID: 29065104]
[http://dx.doi.org/10.4103/0019-509X.204762] [PMID: 28485337]
[http://dx.doi.org/10.14715/cmb/2018.64.13.5] [PMID: 30403591]
[http://dx.doi.org/10.3892/mmr.2018.8894] [PMID: 29693120]
[http://dx.doi.org/10.7150/ijms.68778] [PMID: 36619232]