Login Register Cart 0
Generic placeholder image

Infectious Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Mini-Review Article

A New-fangled COVID-19 Variant, Eris, Might be the One to Lookout in 2023 or far from Over

Author(s): Suman Kumar Ray and Sukhes Mukherjee*

Volume 24, Issue 6, 2024

Published on: 22 January, 2024

Article ID: e220124225916 Pages: 5

DOI: 10.2174/0118715265276833240105110046

Price: $65

conference banner
Abstract

Coronavirus Disease-19 (COVID-19) is an infectious disease brought on by the extremely pathogenic and contagious severe acute respiratory syndrome-virus-2 (SARS-CoV-2). The agenda for the COVID-19 pandemic is dynamic and includes recent developments. Seven variants under monitoring (VUMs), one variant of interest (VOI), XBB.1.5, and their offspring lineages are currently being actively monitored by WHO. The VUMs are BA.2.75, CH.1.1, BQ.1, XBB (with the exception of XBB.1.5, XBB.1.16, and XBB.1.9.1), XBF, and XBB.1.16. With 95 countries having reported finding XBB.1.5 (VOI), it is still the most common strain worldwide, responsible for 47.9% of cases from epidemiological January to March 2023. Seventy nations discovered XBB.1.5 in February and March 2023 and posted sequencing data to GISAID. Of the 43 nations that uploaded more than 50 sequences, XBB.1.5 prevalence has increased to more than 50% in 11 nations. Over 23000 deaths and 3 million new cases were recorded globally in March and April 2023. Worldwide detection of a new COVID-19 strain has prompted specialists to issue a warning that the virus is "circulating unchecked". The Greek goddess of conflict and discord Eris has inspired the nicknaming of EG 5.1, a subvariant of Omicron. The strain is becoming more prevalent in the USA and cases are increasing in the UK. The severity of each SARS-CoV- 2 variant has been comparable, although a more severe form might develop. Eris is an ancestor of Omicron and exhibits some of its characteristics. Reinfection risk can be influenced by a variety of variables, including age, location, and health equity and the COVID-19 vaccine is more or less effective depending on the strain.

Graphical Abstract

[1]
Kang S, Peng W, Zhu Y, et al. Recent progress in understanding 2019 novel coronavirus (SARS-CoV-2) associated with human respiratory disease: Detection, mechanisms and treatment. Int J Antimicrob Agents 2020; 55(5): 105950.
[http://dx.doi.org/10.1016/j.ijantimicag.2020.105950 ] [PMID: 32234465]
[2]
Ray SK, Mukherjee S. Understanding the role of corona virus based on current scientific evidence - A review with emerging importance in pandemic. Recent Patents Anti-Infect Drug Disc 2020; 15(2): 89-103.
[http://dx.doi.org/10.2174/1574891X15999200918144833 ] [PMID: 32957894]
[3]
Shereen MA, Khan S, Kazmi A, Bashir N, Siddique R. COVID-19 infection: Emergence, transmission, and characteristics of human coronaviruses. J Adv Res 2020; 24: 91-8.
[http://dx.doi.org/10.1016/j.jare.2020.03.005 ] [PMID: 32257431]
[4]
Ather A, Patel B, Ruparel NB, Diogenes A, Hargreaves KM. Coronavirus disease 19 (COVID-19): Implications for clinical dental care. J Endod 2020; 46(5): 584-95.
[http://dx.doi.org/10.1016/j.joen.2020.03.008 ] [PMID: 32273156]
[5]
Gorbalenya AE, Baker SC, Baric RS, et al. The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol 2020; 5(4): 536-44.
[http://dx.doi.org/10.1038/s41564-020-0695-z] [PMID: 32123347]
[6]
Polatoğlu I, Oncu-Oner T, Dalman I, Ozdogan S. COVID-19 in early 2023: Structure, replication mechanism, variants of SARS-CoV-2, diagnostic tests, and vaccine & drug development studies. MedComm 2020; 4(2): e228.
[7]
Mohapatra RK, Tiwari R, Sarangi AK, et al. Twin combination of omicron and delta variants triggering a tsunami wave of ever high surges in COVID-19 cases: A challenging global threat with a special focus on the Indian subcontinent. J Med Virol 2022; 94(5): 1761-5.
[http://dx.doi.org/10.1002/jmv.27585] [PMID: 35014038]
[8]
Available from: https://www.outlookindia.com/website/story/business-news-what-is-florona-not-a/408079(Last accessed on August 26, 2023).
[9]
The COVID-19 pandemic in 2023: Far from over. Lancet 2023; 401(10371): 79.
[http://dx.doi.org/10.1016/S0140-6736(23)00050-8 ] [PMID: 36641201]
[10]
Available from: https://economictimes.indiatimes.com/news/international/uk/health-experts-issue-warning-as-eris-variant-rapidly-spreads-across-uk-one-in-seven-COVID-cases-attributed-to-new-variant/articleshow/102430337.cms?utm_source=contentofinterest&utm_medium=text&utm_campaign=cppst (Last accessed on August 26, 2023)
[11]
Available from: https://www.cbsnews.com/news/COVID-variant-eg-5-now-eris/ (Last accessed on August 26, 2023)
[12]
Available from: https://www.hindustantimes.com/lifestyle/health/new-COVID-variant-eris-spreading-rapidly-in-uk-know-symptoms-and-prevention-measures-101691407657712.html(Last accessed on August 26, 2023).
[13]
Mukherjee S, Ray SK. A new wave of COVID-19 in 2021 with unique genetic characters - Present global scenario and beholding onwards. Infect Disord Drug Targets 2022; 22(6): e010422202932.
[http://dx.doi.org/10.2174/1871526522666220401101818 ] [PMID: 35366784]
[14]
Available from: https://www.hindustantimes.com/lifestyle/health/new-COVID-variant-eris-spreading-rapidly-in-uk-know-symptoms-and-prevention-measures-101691407657712.html(Last accessed on August 26, 2023)
[15]
Looi MK. Covid-19: Hospital admissions rise in England amid fears of new variant and waning immunity. BMJ 2023; 382: p1833.
[http://dx.doi.org/10.1136/bmj.p1833] [PMID: 37553176]
[16]
Available from: https://covid.cdc.gov/covid-data-tracker/#variants-genomic-surveillance (Last accessed on August 26, 2023)
[17]
Looi MK. How are COVID-19 symptoms changing. BMJ 2023; 380(3)
[http://dx.doi.org/10.1136/bmj.p3]
[18]
Mahase E. COVID-19: WHAT DO WE KNOW ABOUT XBB.1.5 AND SHOULD WE BE WORRIED? BMJ 2023; 380: 153.
[http://dx.doi.org/10.1136/bmj.p153]
[19]
Available from: https://erictopol.substack.com/p/the-virus-is-learning-new-tricks (Last accessed on August 26, 2023)
[20]
Available from: https://www.ecdc.europa.eu/en/news-events/ecdc-classifies-xbb15-lineages-amino-acid-change-f456l-variants-interest-following (Last accessed on August 26, 2023)
[21]
Available from: https://www.nebraskamed.com/COVID/what-COVID-19-variants-are-going-around (Last accessed on August 26, 2023)
[22]
Available from: https://www.nebraskamed.com/COVID/what-COVID-19-variants-are-going-around (Last accessed on August 26, 2023)
[23]
Available from: https://www.india.com/health/new-COVID-variant-eris-how-is-it-different-from-other-strains-and-who-is-more-at-risk-of-contracting-it-6213093/ (Last accessed on August 26, 2023)
[24]
Available from: https://www.hindustantimes.com/lifestyle/health/new-COVID-variant-eris-spreading-rapidly-in-uk-know-symptoms-and-prevention-measures-101691407657712.html (Last accessed on August 26, 2023)
[25]
Available from: https://www.cnbc.com/2023/08/18/covid-new-vaccines-will-likely-protect-against-eris-variant.html (Last accessed on August 26, 2023)
[26]
Available from: https://www.reuters.com/business/healthcare-pharmaceuticals/new-covid-vaccines-are-way-eris-variant-rises-2023-08-14/ (Last accessed on August 26, 2023)
[27]
Available from: https://www.reuters.com/business/healthcare-pharmaceuticals/modernas-updated-covid-vaccine-effective-against-eris-variant-humans-2023-08-17/ (Last accessed on August 26, 2023)
[28]
Mukherjee S, Ray SK. Challenges in engendering herd immunity to SARS-CoV-2 infection: Possibly impossible but plausibile. Infect Disord Drug Targets 2022; 22(4): e170122200309.
[http://dx.doi.org/10.2174/1871526522666220117153838 ] [PMID: 35040409]
[29]
Rubio-Casillas A, Redwan EM, Uversky VN. SARS-CoV-2: A master of immune evasion. Biomedicines 2022; 10(6): 1339.
[http://dx.doi.org/10.3390/biomedicines10061339] [PMID: 35740361]
[30]
Ali I, Alharbi OML. COVID-19: Disease, management, treatment, and social impact. Sci Total Environ 2020; 728: 138861.
[http://dx.doi.org/10.1016/j.scitotenv.2020.138861 ] [PMID: 32344226]
[31]
Jeyanathan M, Afkhami S, Smaill F, Miller MS, Lichty BD, Xing Z. Immunological considerations for COVID-19 vaccine strategies. Nat Rev Immunol 2020; 20(10): 615-32.
[http://dx.doi.org/10.1038/s41577-020-00434-6] [PMID: 32887954]
[32]
Ray SK, Mukherjee S. From bench side to bed-travelling on a road to get a safe and effective vaccine against covid-19, day to save the life. Recent Pat Biotechnol 2022; 16(1): 2-5.
[http://dx.doi.org/10.2174/1872208315666211209094457 ] [PMID: 34886784]
[33]
Martinelli L, Kopilaš V, Vidmar M, et al. Face masks during the COVID-19 Pandemic: A simple protection tool with many meanings. Front Public Health 2021; 8: 606635.
[http://dx.doi.org/10.3389/fpubh.2020.606635] [PMID: 33520918]
[34]
Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public (Last accessed on August 26, 2023)
[35]
Available from: https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/prevention.html (Last accessed on August 26, 2023)
[36]
Available from: https://www.nidirect.gov.uk/articles/coronavirus-covid-19-how-stay-safe-and-help-prevent-spread (Last accessed on August 26, 2023)
[37]
Zella D, Giovanetti M, Cella E, et al. The importance of genomic analysis in cracking the coronavirus pandemic. Expert Rev Mol Diagn 2021; 21(6): 547-62.
[http://dx.doi.org/10.1080/14737159.2021.1917998 ] [PMID: 33849359]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy