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Research Article

Development of Phytoconstituents from Spathodea campanulata Flowers as Potential Antimalarial Agents

Author(s): Abin V. Geevarghese*, Maida E.S. Emimmal, Ida C.V. Elizabeth, Poovarasan Krishnan, Sarulatha M. Sumathi and Thirumal Perumal

Volume 22, Issue 3, 2024

Published on: 19 January, 2024

Article ID: e190124225834 Pages: 17

DOI: 10.2174/0122113525275435231205111538

Price: $65

Abstract

Background: Considering the majority of pharmaceutical firms focus on using herbal remedies as an alternative source of essential components, herbal remedies are extremely significant to pharmacological researchers. Spathodea campanulata is one of the members of the Bignoniaceae family. It is popular for its curative properties.

Aim: This research aimed to assess the possibility of bioactive elements and antioxidant impacts of the methanol fraction of Spathodea campanulata flowers.

Objectives: The objective of this research was to assess the achievable bioactive elements and antioxidant impacts of the methanol fraction of Spathodea campanulata flowers.

Methods: GC-MS was adopted to identify the phytoconstituents present in the extract. In the present study, we utilized computational modelling with the Schrödinger Maestro 11.2 edition to make benefit of interactions among 42 bio-active components and anti-malarial targets (1LDG and 2ANL).

Results: In the methanol extract of the Spathodea campanulata flowers, phytochemical research revealed the presence of terpenoids, glycosides, carbohydrates, steroids, and flavonoids. Forty-two phytoconstituents, notably methyl-beta-d-galactopyranoside, 4-hydroxybenzoic acid, and 1,2- ethanediol monobenzoate, were determined through GC-MS analysis. Docking analysis of 42 bioactive compounds demonstrated that 1,2-ethanediol mono benzoate, 4-hydroxy benzoic acid, and methyl. beta.-d-galactopyranoside had higher G-Scores with 1LDG and 2ANL.

Conclusion: In this work, multiple phytoconstituents discovered in a methanol extract of the S. campanulata flower were determined. As a result of this research, four phytoconstituents from the flower extracts may be created as an exciting new therapy for malaria.

Graphical Abstract

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