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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Research Article

Design, Synthesis and Characterization of Deoxycholic Acid-chalcone Conjugates as Antioxidant Agents

Author(s): Sejal Patel and Satyendra Mishra*

Volume 28, Issue 1, 2024

Published on: 17 January, 2024

Page: [32 - 39] Pages: 8

DOI: 10.2174/0113852728280936231221110245

Price: $65

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Abstract

The present article reports the synthesis, characterization, and antioxidant activity of the chalcone-deoxycholic acid conjugates. The structures of the synthesised bile acidchalcone conjugates have been determined using 1H and 13C NMR spectroscopy. According to the results of the DPPH experiment, compounds 5e (3, 4, 5-methoxy; IC50; 15.04 μg /ml) and 5f (4-hydroxy group; IC50; 11.73 μg /ml) had higher antioxidant activity than the control compound ascorbic acid (IC50; 20.72 μg /ml). The best conjugate was found to be 5f in the DPPH test (IC50: 11.73 μg /ml; 4-hydroxy group), while the best conjugate in the ABTS assay was found to be 5g (IC50: 67.97 μg /ml; pyridine group). It is straightforward to synthesize a huge library of bile acid-derived compounds and employ them in comprehensive structure-activity relationship investigations to identify the compounds with the best antioxidant activity.

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