Login Register Cart 0
Generic placeholder image

Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Systematic Review Article

Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Author(s): Mohammad Ali Goudarzi, Zahra Sohrabi, Mohammad Hashem Hashempur, Saeed Nosratabadi, Zahra Namkhah, Cain C.T. Clark and Neda Haghighat*

Volume 25, Issue 2, 2024

Published on: 21 December, 2023

Page: [121 - 134] Pages: 14

DOI: 10.2174/0113894501272740231219072525

Price: $65

Abstract

Introduction: There is a growing interest in the considerable benefits of grape products intake, as some studies have indicated that they may improve cardiometabolic risk factors. However, the widespread impact of grape products on the anthropometric indices is not fully resolved.

Method: The purpose of this systematic review and meta-analysis was to examine the effects of grape products intake on anthropometric indices in adults. Randomized controlled trials (RCT) examining the effects of grape products intake on anthropometric indices, published up to December 2021, were identified through PubMed, SCOPUS, and ISI Web of Science databases. 30 studies with 35 effect sizes, including 1284 participants (708 cases and 576 controls), were included and analyzed using a random-effects model to calculate weighted mean differences (WMDs) with 95% confidence interval (CI).

Result: The outcomes have revealed grape products intake to significantly decrease body weight (p = 0.001) and body mass index (p = 0.004) in obese participants, and also, a greater effect was observed when grape seed extract was used.

Conclusion: Our study suggests that grape products intake may help to decrease body weight in obese participants. Future large RCTs with longer duration and obese populations are needed to expand our findings.

« Previous Next »
Graphical Abstract

[1]
Bazzano LA, Serdula MK, Liu S. Dietary intake of fruits and vegetables and risk of cardiovascular disease. Curr Atheroscler Rep 2003; 5(6): 492-9.
[http://dx.doi.org/10.1007/s11883-003-0040-z] [PMID: 14525683]
[2]
Riboli E, Norat T. Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 2003; 78(3) (Suppl.): 559S-69S.
[http://dx.doi.org/10.1093/ajcn/78.3.559S] [PMID: 12936950]
[3]
Hollis JH, Houchins JA, Blumberg JB, Mattes RD. Effects of concord grape juice on appetite, diet, body weight, lipid profile, and antioxidant status of adults. J Am Coll Nutr 2009; 28(5): 574-82.
[http://dx.doi.org/10.1080/07315724.2009.10719789] [PMID: 20439553]
[4]
Terra X, Montagut G, Bustos M, et al. Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet. J Nutr Biochem 2009; 20(3): 210-8.
[http://dx.doi.org/10.1016/j.jnutbio.2008.02.005] [PMID: 18602813]
[5]
Williams RJ, Spencer JPE, Rice-Evans C. Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med 2004; 36(7): 838-49.
[http://dx.doi.org/10.1016/j.freeradbiomed.2004.01.001] [PMID: 15019969]
[6]
de Sá Coutinho D, Pacheco M, Frozza R, Bernardi A. Anti-inflammatory effects of resveratrol: Mechanistic insights. Int J Mol Sci 2018; 19(6): 1812.
[http://dx.doi.org/10.3390/ijms19061812] [PMID: 29925765]
[7]
Pérez-Cano FJ, Castell M. Flavonoids, inflammation and immune system. Multidisciplinary Digital Publishing Institute 2016; p. 659.
[8]
Xia EQ, Deng GF, Guo YJ, Li HB. Biological activities of polyphenols from grapes. Int J Mol Sci 2010; 11(2): 622-46.
[http://dx.doi.org/10.3390/ijms11020622] [PMID: 20386657]
[9]
Asbaghi O, Nazarian B, Reiner Ž, et al. The effects of grape seed extract on glycemic control, serum lipoproteins, inflammation, and body weight: A systematic review and meta-analysis of randomized controlled trials. Phytother Res 2020; 34(2): 239-53.
[http://dx.doi.org/10.1002/ptr.6518] [PMID: 31880030]
[10]
Ghalishourani SS, Farzollahpour F, Shirinbakhshmasoleh M, et al. Effects of grape products on inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Phytother Res 2021; 35(9): 4898-912.
[http://dx.doi.org/10.1002/ptr.7120] [PMID: 33908079]
[11]
Moodi V, Abedi S, Esmaeilpour M, et al. The effect of grapes/grape products on glycemic response: A systematic review and meta-analysis of randomized controlled trials. Phytother Res 2021; 35(9): 5053-67.
[http://dx.doi.org/10.1002/ptr.7135] [PMID: 33893683]
[12]
Parandoosh M, Yousefi R, Khorsandi H, Nikpayam O, Saidpour A, Babaei H. The effects of grape seed extract (Vitis vinifera ) supplement on inflammatory markers, neuropeptide Y, anthropometric measures, and appetite in obese or overweight individuals: A randomized clinical trial. Phytother Res 2020; 34(2): 379-87.
[http://dx.doi.org/10.1002/ptr.6529] [PMID: 31713941]
[13]
Haghighat N, Ashtary-Larky D, Bagheri R, et al. Effects of 6 months of soy-enriched high protein compared to eucaloric low protein snack replacement on appetite, dietary intake, and body composition in normal-weight obese women: a randomized controlled trial. Nutrients 2021; 13(7): 2266.
[http://dx.doi.org/10.3390/nu13072266] [PMID: 34208986]
[14]
Charradi K, Sebai H, Elkahoui S, Ben Hassine F, Limam F, Aouani E. Grape seed extract alleviates high-fat diet-induced obesity and heart dysfunction by preventing cardiac siderosis. Cardiovasc Toxicol 2011; 11(1): 28-37.
[http://dx.doi.org/10.1007/s12012-010-9101-z] [PMID: 21234706]
[15]
Moreno DA, Ilic N, Poulev A, Brasaemle DL, Fried SK, Raskin I. Inhibitory effects of grape seed extract on lipases. Nutrition 2003; 19(10): 876-9.
[http://dx.doi.org/10.1016/S0899-9007(03)00167-9] [PMID: 14559324]
[16]
Park SH, Park TS, Cha YS. Grape seed extract (Vitis vinifera) partially reverses high fat diet-induced obesity in C57BL/6J mice. Nutr Res Pract 2008; 2(4): 227-33.
[http://dx.doi.org/10.4162/nrp.2008.2.4.227] [PMID: 20016723]
[17]
Bargallo M, Grau A, Fernándezlarrea J, et al. Moderate red-wine consumption partially prevents body weight gain in rats fed a hyperlipidic diet. J Nutr Biochem 2006; 17(2): 139-42.
[http://dx.doi.org/10.1016/j.jnutbio.2005.06.005] [PMID: 16169198]
[18]
Kao YH, Hiipakka RA, Liao S. Modulation of endocrine systems and food intake by green tea epigallocatechin gallate. Endocrinology 2000; 141(3): 980-7.
[http://dx.doi.org/10.1210/endo.141.3.7368] [PMID: 10698173]
[19]
Abdali D, Samson SE, Grover AK. How effective are antioxidant supplements in obesity and diabetes? Med Princ Pract 2015; 24(3): 201-15.
[http://dx.doi.org/10.1159/000375305] [PMID: 25791371]
[20]
Natella F, Belelli F, Gentili V, Ursini F, Scaccini C. Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans. J Agric Food Chem 2002; 50(26): 7720-5.
[http://dx.doi.org/10.1021/jf020346o] [PMID: 12475295]
[21]
Pascual-Serrano A, Arola-Arnal A, Suárez-García S, et al. Grape seed proanthocyanidin supplementation reduces adipocyte size and increases adipocyte number in obese rats. Int J Obes 2017; 41(8): 1246-55.
[http://dx.doi.org/10.1038/ijo.2017.90] [PMID: 28373675]
[22]
Dave A, Park EJ, Kumar A, et al. Consumption of grapes modulates gene expression, reduces non-alcoholic fatty liver disease, and extends longevity in female C57BL/6J mice provided with a high-fat Western-pattern diet. Foods 2022; 11(13): 1984.
[http://dx.doi.org/10.3390/foods11131984] [PMID: 35804799]
[23]
Vogels N, Nijs IMT, Westerterp-Plantenga MS. The effect of grape-seed extract on 24 h energy intake in humans. Eur J Clin Nutr 2004; 58(4): 667-73.
[http://dx.doi.org/10.1038/sj.ejcn.1601863] [PMID: 15042136]
[24]
Tebib K, Besançon P, Rouanet JM. Effects of dietary grape seed tannins on rat cecal fermentation and colonic bacterial enzymes. Nutr Res 1996; 16(1): 105-10.
[http://dx.doi.org/10.1016/0271-5317(95)02064-0]
[25]
Preuss HG, Bagchi D, Bagchi M, Rao CVS, Dey DK, Satyanarayana S. Effects of a natural extract of (–)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab 2004; 6(3): 171-80.
[http://dx.doi.org/10.1111/j.1462-8902.2004.00328.x] [PMID: 15056124]
[26]
Duclos Q. Effects of A Standardized, Freeze-Dried Grape Powder in Adults with Metabolic Syndrome. Master's Theses 2017.
[27]
Kanellos PT, Kaliora AC, Tentolouris NK, et al. A pilot, randomized controlled trial to examine the health outcomes of raisin consumption in patients with diabetes. Nutrition 2014; 30(3): 358-64.
[http://dx.doi.org/10.1016/j.nut.2013.07.020] [PMID: 24262513]
[28]
Dohadwala MM, Hamburg NM, Holbrook M, et al. Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension. Am J Clin Nutr 2010; 92(5): 1052-9.
[http://dx.doi.org/10.3945/ajcn.2010.29905] [PMID: 20844075]
[29]
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009; 6(7): e1000097.
[http://dx.doi.org/10.1371/journal.pmed.1000097] [PMID: 19621072]
[30]
Higgins JPT, Altman DG, Gøtzsche PC, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 2011; 343(oct18 2): d5928.
[http://dx.doi.org/10.1136/bmj.d5928] [PMID: 22008217]
[31]
DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986; 7(3): 177-88.
[http://dx.doi.org/10.1016/0197-2456(86)90046-2] [PMID: 3802833]
[32]
Borenstein M, Hedges LV, Higgins JP, Rothstein HR. Introduction to meta-analysis. John Wiley & Sons 2021.
[http://dx.doi.org/10.1002/9781119558378]
[33]
Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 2005; 5(1): 13.
[http://dx.doi.org/10.1186/1471-2288-5-13] [PMID: 15840177]
[34]
Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003; 327(7414): 557-60.
[http://dx.doi.org/10.1136/bmj.327.7414.557] [PMID: 12958120]
[35]
Tobias A. Assessing the influence of a single study in the meta-anyalysis estimate. Stata Tech Bull 1999; 8(47)
[36]
Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315(7109): 629-34.
[http://dx.doi.org/10.1136/bmj.315.7109.629] [PMID: 9310563]
[37]
Banini AE, Boyd LC, Allen JC, Allen HG, Sauls DL. Muscadine grape products intake, diet and blood constituents of non-diabetic and type 2 diabetic subjects. Nutrition 2006; 22(11-12): 1137-45.
[http://dx.doi.org/10.1016/j.nut.2006.08.012] [PMID: 17030113]
[38]
Krikorian R, Boespflug EL, Fleck DE, et al. Concord grape juice supplementation and neurocognitive function in human aging. J Agric Food Chem 2012; 60(23): 5736-42.
[http://dx.doi.org/10.1021/jf300277g] [PMID: 22468945]
[39]
Riche DM, Riche KD, Blackshear CT, McEwen CL, Sherman JJ, Wofford MR. Pterostilbene on metabolic parameters: A randomized, double-blind, and placebo-controlled trial. Evid Based Complement Alternat Med 2014; 2014: 459165.
[http://dx.doi.org/10.1155/2014/459165]
[40]
Park YK, Kim JS, Kang MH. Concord grape juice supplementation reduces blood pressure in Korean hypertensive men: Double-blind, placebo controlled intervention trial. Biofactors 2004; 22(1-4): 145-7.
[http://dx.doi.org/10.1002/biof.5520220128] [PMID: 15630270]
[41]
Hansen AS, Marckmann P, Dragsted LO, Finné Nielsen IL, Nielsen SE, Grønbæk M. Effect of red wine and red grape extract on blood lipids, haemostatic factors, and other risk factors for cardiovascular disease. Eur J Clin Nutr 2005; 59(3): 449-55.
[http://dx.doi.org/10.1038/sj.ejcn.1602107] [PMID: 15674304]
[42]
Sano A, Uchida R, Saito M, et al. Beneficial effects of grape seed extract on malondialdehyde-modified LDL. J Nutr Sci Vitaminol (Tokyo) 2007; 53(2): 174-82.
[http://dx.doi.org/10.3177/jnsv.53.174] [PMID: 17616006]
[43]
Terauchi M, Horiguchi N, Kajiyama A, et al. Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women. Menopause 2014; 21(9): 990-6.
[http://dx.doi.org/10.1097/GME.0000000000000200] [PMID: 24518152]
[44]
Odai T, Terauchi M, Kato K, Hirose A, Miyasaka N. Effects of Grape Seed Proanthocyanidin Extract on Vascular Endothelial Function in Participants with Prehypertension: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients 2019; 11(12): 2844.
[http://dx.doi.org/10.3390/nu11122844] [PMID: 31757033]
[45]
Tomé-Carneiro J, Larrosa M, Yáñez-Gascón MJ, et al. One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res 2013; 72: 69-82.
[http://dx.doi.org/10.1016/j.phrs.2013.03.011] [PMID: 23557933]
[46]
Yubero N, Sanz-Buenhombre M, Guadarrama A, et al. LDL cholesterol-lowering effects of grape extract used as a dietary supplement on healthy volunteers. Int J Food Sci Nutr 2013; 64(4): 400-6.
[http://dx.doi.org/10.3109/09637486.2012.753040] [PMID: 23249415]
[47]
Jiménez JP, Serrano J, Tabernero M, et al. Effects of grape antioxidant dietary fiber in cardiovascular disease risk factors. Nutrition 2008; 24(7-8): 646-53.
[http://dx.doi.org/10.1016/j.nut.2008.03.012] [PMID: 18485668]
[48]
Lafay S, Jan C, Nardon K, et al. Grape extract improves antioxidant status and physical performance in elite male athletes. J Sports Sci Med 2009; 8(3): 468-80.
[PMID: 24150013]
[49]
Hokayem M, Blond E, Vidal H, et al. Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients. Diabetes Care 2013; 36(6): 1454-61.
[http://dx.doi.org/10.2337/dc12-1652] [PMID: 23275372]
[50]
Pourghassem-Gargari B, Abedini S, Babaei H, Aliasgarzadeh A, Pourabdollahi P. Effect of supplementation with grape seed (Vitis vinifera) extract on antioxidant status and lipid peroxidation in patient with type diabetes. J Med Plants Res 2011; 5(10): 2029-34.
[51]
Saedmocheshi S. The effect of grape seed extract and aerobic activity on lipid profile in obese elderly women. Journal of Basic Research in Medical Sciences 2014; 1(2): 8-14.
[52]
Saedmocheshi S, Saedmocheshi L, Almori MR, Ghafari G. The effects of regular aerobic training and grape seed extract on the cardiovascular risk factors in obese older women. Majallah-i Ilmi-i Danishgah-i Ulum-i Pizishki-i Kurdistan 2015; 20(3): 69-78.
[53]
Farideh S, Parvin J, Nooshin AM, et al. Effect of raisin consumption on some coagulation factors and total serum antioxidant capacity in hyperlipidemic patients: A randomized clinical controlled tria. Iran J Endocrinol Metab 2017; 19(1): 50-60.
[54]
Babaei H, Aliasgarzadeh A, Poorabdollahi P. Effect of supplementation with grape seed extract (vitis vinifera) on serum lipid profiles in patient with type 2 diabetes. Majallah-i Ghudad-i Darun/Riz va Mitabulism-i Iran 2013; 15(1): 59-66.
[55]
Moradi H, Nikbakht H, Ebrahim K, Abed Natanzi H. The effects of aerobic training and grape seed extract on some cardiovascular risk indexes in young men. Iran J Nutr Sci Food Technol 2017; 12(2): 27-34.
[56]
Kanellos PT, Kaliora AC, Protogerou AD, Tentolouris N, Perrea DN, Karathanos VT. The effect of raisins on biomarkers of endothelial function and oxidant damage; an open-label and randomized controlled intervention. Food Res Int 2017; 102: 674-80.
[http://dx.doi.org/10.1016/j.foodres.2017.09.061] [PMID: 29195999]
[57]
Kaliora AC, Kokkinos A, Diolintzi A, et al. The effect of minimal dietary changes with raisins in NAFLD patients with non-significant fibrosis: a randomized controlled intervention. Food Funct 2016; 7(11): 4533-44.
[http://dx.doi.org/10.1039/C6FO01040G] [PMID: 27714002]
[58]
Siasos G, Tousoulis D, Kokkou E, et al. Favorable effects of concord grape juice on endothelial function and arterial stiffness in healthy smokers. Am J Hypertens 2014; 27(1): 38-45.
[http://dx.doi.org/10.1093/ajh/hpt176] [PMID: 24061071]
[59]
O’Connor PJ, Caravalho AL, Freese EC, Cureton KJ. Grape consumption’s effects on fitness, muscle injury, mood, and perceived health. Int J Sport Nutr Exerc Metab 2013; 23(1): 57-64.
[http://dx.doi.org/10.1123/ijsnem.23.1.57] [PMID: 22952194]
[60]
Shin HS, Kindleysides S, Yip W, Budgett SC, Ingram JR, Poppitt SD. Postprandial effects of a polyphenolic grape extract (PGE) supplement on appetite and food intake: a randomised dose-comparison trial. Nutr J 2015; 14(1): 96.
[http://dx.doi.org/10.1186/s12937-015-0085-1] [PMID: 26370656]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy