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Review Article

Role of Omega-3PUFA: A Nutraceutical for Brain Functioning and Treatment of Mental Disorders

Author(s): Ishu Garg, Raj Kumari* and Meenakshi Sharma

Volume 1, 2023

Published on: 14 December, 2023

Article ID: e2210299X255340 Pages: 15

DOI: 10.2174/012210299X255340231115095951

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Abstract

Concerning the past few years in terms of health and nature, the globe has witnessed an upsurge in the use of nutraceuticals and nutritional and natural products in therapeutics. The major reason for this step is the conventional pharmacological treatment using synthetic drugs that do not meet the status of health and therapeutic requirements for various pathological conditions. Nutraceuticals promise prominent health and therapeutic benefits with no adverse or side effects, providing extra health benefits besides their action in any defined pathological condition. Nutraceuticals are extensive biological therapies that include herbs, vitamins, fatty acids, prebiotics, and probiotics used to promote and maintain health to prevent and cure pathological conditions, malignant processes, syndromes, and symptoms. Nutraceuticals have multidirectional therapeutic benefits and are claimed to be effective products in aiding human health. The addition of omega-3 for the treatment of mental and mood disorders was found to have safer, more valuable, and better therapeutic results in comparison to the use of synthetic drugs. Omega-3 is available in the regular diet through soybeans, walnuts, codfish, and salmon fish, and its constituents have been found to play a promising role in brain development, including brain aging and neurodegenerative disorders, in the pathology of mental and mood disorders, and treatment of the same. Supplementation with Omega-3 PUFA provides a promising effect in better brain development, treatment, prevention and cure of mental and mood disorders. This review endeavours to display and assert the clinical relevance of omega-3 PUFA in brain development, pathology, and treatment of mental and mood disorders.

[1]
Chaudhari, S.P.; Priyatama, V.; Pratapwar, M.N. Nutraceuticals: A review. World J. Pharm. Pharm. Sci., 2017, 6(8), 681-739.
[http://dx.doi.org/10.20959/wjpps20178-9825]
[2]
Singh, J.; Sinha, S. Classification, regulatory acts and applications of nutraceuticals for health: A review. Int. J. Pharm. Biol. Sci., 2012, 2, 177-187.
[3]
Maxwell, J. Food as pharma as wellness products evolve, the distinction between food and medicine blurs. R&C Worlds Express, 2012.https://www.pwc.com/gx/en/retail-consumer/pdf/rc-worlds-newsletter-foods-final.pdf
[4]
Kokate, C.K.; Purohit, A.P.; Gokhale, S.B. Pharmacognosy, 55th ed; Nirali Prakashan: India, 2008.
[5]
Lodhi, S.; Rageeb, Md.; Usman, Md.; Tushar, A.; Deshmukh, K.; Vaibhav, M.; Darvhekar, K.; Mohan, L.K. A textbook of Herbal Drug Technology; Nirali Prakashan: India, 2019.
[6]
Kumar, P.; Nirdesh, K.; Omer, T. Nutraceuticals- critical supplement for building a healthy India. World J. Pharm. Pharm. Sci., 2016, 5, 579-594.
[7]
Olaiya, C.O.; Soetan, K.O.; Esan, A.M. The role of nutraceuticals, functional foods and value added food products in the prevention and treatment of chronic diseases. Afr. J. Food Sci., 2016, 10(10), 185-193.
[http://dx.doi.org/10.5897/AJFS2015.1402]
[8]
Namdeo, S.; Bhaskar, B.; Sunil, D.; Kumbhar, P. Nutraceuticals: A review on current status. Research J. Pharm. and Tech, 2014, 7, 110-113.
[9]
Kharb, S.; Singh, V. Nutriceuticals in health and disease prevention. Indian J. Clin. Biochem., 2004, 19(1), 50-53.
[http://dx.doi.org/10.1007/BF02872389] [PMID: 23105426]
[10]
Ahad, T.; Nissar, J.; Rather, A.H. Nutraceuticals health-benefits: A review. International Journal of Engineering Technology Science and Research, 2007, 4, 262-265.
[11]
Keservani, R.K.; Singh, Swati; Singh, V.; Kesharwani, R.K.; Sharma, A.K. Nutraceuticals and Functional Foods in the Prevention of Mental Disorders: A review: Nutraceuticals and Functional Foods in Human Health and Disease Prevention Bagchi Debasis, Preuss Harry G., Swaroop Anand, CRC Press, 2016; pp. 255-265.
[12]
Hardy, G.N.; Foods, F. Nutraceuticals and Functional Foods. Introduction and Meaning Nutraceutical, 2000, 16, 718-719.
[13]
Kathleen, C; Stephen, D. Nutraceuticals: What Are They and Do They Work? Kentucky Equine Research, Inc. Versailles, KY, 2013, 7, 1-50.
[14]
Kasbia, G.S. Functional foods and nutraceuticals in the management of obesity. Nutr. Food Sci., 2005, 35(5), 344-352.
[http://dx.doi.org/10.1108/00346650510625557]
[15]
Thomas, B.; Ghebremeskel, K.; Lowy, C.; Crawford, M.; Offley-Shore, B. Nutrient intake of women with and without gestational diabetes with a specific focus on fatty acids. Nutrition, 2006, 22(3), 230-236.
[http://dx.doi.org/10.1016/j.nut.2005.07.017] [PMID: 16500549]
[16]
Frydoonfar, H.R.; McGrath, D.R.; Spigelman, A.D. The variable effect on proliferation of a colon cancer cell line by the citrus fruit flavonoid Naringenin. Colorectal Dis., 2003, 5(2), 149-152.
[http://dx.doi.org/10.1046/j.1463-1318.2003.00444.x] [PMID: 12780904]
[17]
McMILLAN, D.C.; Talwar, D.; Sattar, N.; Underwood, M.; St J O’Reilly, D.; McARDLE, C.O.L.I.N. The relationship between reduced vitamin antioxidant concentrations and the systemic inflammatory response in patients with common solid tumours. Clin. Nutr., 2002, 21(2), 161-164.
[http://dx.doi.org/10.1054/clnu.2001.0527] [PMID: 12056790]
[18]
18. Prine health primary nephrology, best vitamins for kidney disease - what are they - PRINE health 2002.
[19]
Anne, W.; Allison, G. Ross and Wilson Anatomy and Physiology in Health and Illness Churchill Livingstone: Edinburgh london new york oxford philadelphiast louis sydney and Toronto, 2001.
[20]
Anatomy of Brain, Mayfield Brain & Spine, Brain anatomy, Anatomy of the human brain | Mayfield Brain & Spine Cincinnati, Ohio (mayfieldclinic.com),
[21]
Tripathi, K.D. Essential of Medical Pharmacology, Eight edition, Jaypee Brothers Medical Publishers (P) Ltd; The Health Services Publisher: New Delhi, 2018.
[22]
Mohan, H. Textbook of Pathology, Seventh edition; Jaypee Brothers Medical Publishers (P) Ltd., : New Delhi, 2015.
[http://dx.doi.org/10.5005/jp/books/12412]
[23]
Roberfroid, M.B. Global view on functional foods: European perspectives. Br. J. Nutr., 2002, 88(S2)(Suppl. 2), S133-S138.
[http://dx.doi.org/10.1079/BJN2002677] [PMID: 12495454]
[24]
Menrad, K. Market and marketing of functional food in Europe. J. Food Eng., 2003, 56(2-3), 181-188.
[http://dx.doi.org/10.1016/S0260-8774(02)00247-9]
[25]
Keservani, R.K.; Vyas, N.; Jain, S.; Raghuvanshi, R.; Sharma, A.K. Nutraceutical and functional food as future food: A review. Pharm. Lett., 2010, 2, 106-116.
[26]
Lichtenstein, A.H. Thematic review series: Patient-oriented research. dietary fat, carbohydrate, and protein: effects on plasma lipoprotein patterns. J. Lipid Res., 2006, 47(8), 1661-1667.
[http://dx.doi.org/10.1194/jlr.R600019-JLR200] [PMID: 16738356]
[27]
Parker, G.; Gibson, N.A.; Brotchie, H.; Heruc, G.; Rees, A.M.; Hadzi-Pavlovic, D. Omega-3 fatty acids and mood disorders. Am. J. Psychiatry, 2006, 163(6), 969-978.
[http://dx.doi.org/10.1176/ajp.2006.163.6.969] [PMID: 16741195]
[28]
Isabelle, D.; Gaelle, C.P. Advancing age, and brain function a review, nutraceuticals and functional foods in human health and disease prevention Bagchi Debasis, Preuss Harry G., Swaroop Anand, CRC Press, 2016; pp. 217-232.
[29]
Fereidoon, S.; Priyatharini, A. Omega-3 polyunsaturated fatty acids and their health benefits. Annu. Rev. Food Sci. Technol., 2016, 352-366.
[30]
Dietit, C. Food Sources of Omega-3 Fats., 2013.https://blogs.dal.ca/nutritioncorner/files/2020/02/Omega-3.pdf
[31]
Shahidi, F.; Miraliakbari, H. Omega-3 (n-3) fatty acids in health and disease: Part 1--cardiovascular disease and cancer. J. Med. Food, 2004, 7(4), 387-401.
[http://dx.doi.org/10.1089/jmf.2004.7.387] [PMID: 15671680]
[32]
Shahidi, F.; Miraliakbari, H. Marine oils: Compositional characteristics and health effects, nutraceutical and specialty lipids and their co-products; Shahidi, F., Ed.; CRC Press: Boca Raton, FL, 2006, pp. 227-250.
[33]
Shahidi, F. Functional seafood lipids and proteins, Functional Foods: Biochemical and Processing Aspects; Mazza, G., Ed.; Technomic Publ: Lancaster, UK, 1998, pp. 381-401.
[34]
Harimana, Y.; Sameh, A.K.; Abdelmoneim, H.A.; Marie, A.T.; Ildephonse, H.; Sherif, M. Abed, extraction, refining and purification of ω-3 pufa through different techniques – a review. American Journal of Food Science and Nutrition Research, 2016, 4, 18-26.
[35]
Botineştean, C.; Gruia, A.T.; Jianu, I. Utilization of seeds from tomato processing wastes as raw material for oil production. J. Mater. Cycles Waste Manag., 2015, 17(1), 118-124.
[http://dx.doi.org/10.1007/s10163-014-0231-4]
[36]
Chantachum, S.; Benjakul, S.; Sriwirat, N. Separation and quality of fish oil from precooked and non-precooked tuna heads. Food Chem., 2000, 69(3), 289-294.
[http://dx.doi.org/10.1016/S0308-8146(99)00266-6]
[37]
Linder, M.; Fanni, J.; Parmentier, M. Proteolytic extraction of salmon oil and PUFA concentration by lipases. Mar. Biotechnol., 2005, 7(1), 70-76.
[http://dx.doi.org/10.1007/s10126-004-0149-2] [PMID: 15759086]
[38]
Rolle, R.S. Review: Enzyme applications for agro-processing in developing countries: An inventory of current and potential applications. World J. Microbiol. Biotechnol., 1998, 14(5), 611-619.
[http://dx.doi.org/10.1023/A:1008896500986]
[39]
Cvengros, J. Physical refining of edible oils. J. Am. Oil Chem. Soc., 1995, 72(10), 1193-1196.
[http://dx.doi.org/10.1007/BF02540987]
[40]
Adlof, R.O.; Emken, E.A. The isolation of omega‐3 polyunsaturated fatty acids and methyl esters of fish oils by silver resin chromatography. J. Am. Oil Chem. Soc., 1985, 62(11), 1592-1595.
[http://dx.doi.org/10.1007/BF02541694]
[41]
Senanayake, S.P.J.N.; Shahidi, F. Concentration of docosahexaenoic acid (DHA) from algal oil via urea complexation. J. Food Lipids, 2000, 7(1), 51-61.
[http://dx.doi.org/10.1111/j.1745-4522.2000.tb00160.x]
[42]
Hayes, D.G.; Van Alstine, J.M.; Setterwall, F. Urea‐based fractionation of seed oil samples containing fatty acids and acylglycerols of polyunsaturated and hydroxy fatty acids. J. Am. Oil Chem. Soc., 2000, 77(2), 207-213.
[http://dx.doi.org/10.1007/s11746-000-0033-5]
[43]
Hwang, L.S.; Liang, J.H. Fractionation of urea‐pretreated squid visceral oil ethyl esters. J. Am. Oil Chem. Soc., 2001, 78(5), 473-476.
[http://dx.doi.org/10.1007/s11746-001-0288-x]
[44]
Hayashi, K.; Kishimura, H. Preparation of n-3 PUFA ethyl-ester concentrates from fish-oil by column chromatography on silicic-acid. Nippon Suisan Gakkaishi, 1993, 59(8), 1429.
[http://dx.doi.org/10.2331/suisan.59.1429]
[45]
Bousquet, O.; Le Goffic, F. Counter-current chromatographic separation of polyunsaturated fatty acids. J. Chromatogr. A, 1995, 704(1), 211-216.
[http://dx.doi.org/10.1016/0021-9673(94)01233-5]
[46]
Mozaffarian, D.; Wu, J.H.Y. Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J. Am. Coll. Cardiol., 2011, 58(20), 2047-2067.
[http://dx.doi.org/10.1016/j.jacc.2011.06.063] [PMID: 22051327]
[47]
Patel, J.; Patel, A.S. The Role of Nutritional Factors in Pathogenesis of Diseases, Nutrigenomics and Nutraceuticals Clinical Relevance and Disease Prevention; Yashwant V. Pathak Ali M. Ardekani. CRC Press, 2018, pp. 483-505.
[48]
Shi, Y.; Burn, P. Lipid metabolic enzymes: Emerging drug targets for the treatment of obesity. Nat. Rev. Drug Discov., 2004, 3(8), 695-710.
[http://dx.doi.org/10.1038/nrd1469] [PMID: 15286736]
[49]
Beckermann, B.; Beneke, M.; Seitz, I. [Comparative bioavailability of eicosapentaenoic acid and docasahexaenoic acid from triglycerides, free fatty acids and ethyl esters in volunteers]. Arzneimittelforschung, 1990, 40(6), 700-704.
[PMID: 2144420]
[50]
Ailhaud, G.; Massiera, F.; Weill, P.; Legrand, P.; Alessandri, J.; Guesnet, P. Temporal changes in dietary fats: Role of n−6 polyunsaturated fatty acids in excessive adipose tissue development and relationship to obesity. Prog. Lipid Res., 2006, 45(3), 203-236.
[http://dx.doi.org/10.1016/j.plipres.2006.01.003] [PMID: 16516300]
[51]
Champeil-Potokar, G.; Denis, I.; Goustard-Langelier, B.; Alessandri, J.M.; Guesnet, P.; Lavialle, M. Astrocytes in culture require docosahexaenoic acid to restore the n‐3/n‐6 polyunsaturated fatty acid balance in their membrane phospholipids. J. Neurosci. Res., 2004, 75(1), 96-106.
[http://dx.doi.org/10.1002/jnr.10817] [PMID: 14689452]
[52]
Cunnane, S.C.; Francescutti, V.; Brenna, J.T.; Crawford, M.A. Breast‐fed infants achieve a higher rate of brain and whole body docosahexaenoate accumulation than formula‐fed infants not consuming dietary docosahexaenoate. Lipids, 2000, 35(1), 105-111.
[http://dx.doi.org/10.1007/s11745-000-0501-6] [PMID: 10695931]
[53]
Stillwell, W.; Wassall, S.R. Docosahexaenoic acid: Membrane properties of a unique fatty acid. Chem. Phys. Lipids, 2003, 126(1), 1-27.
[http://dx.doi.org/10.1016/S0009-3084(03)00101-4] [PMID: 14580707]
[54]
Fedorova, I.; Salem, N., Jr Omega-3 fatty acids and rodent behavior. Prostaglandins Leukot. Essent. Fatty Acids, 2006, 75(4-5), 271-289.
[http://dx.doi.org/10.1016/j.plefa.2006.07.006] [PMID: 16973342]
[55]
Nedergaard, M.; Verkhratsky, A. Artifact versus reality-How astrocytes contribute to synaptic events. Glia, 2012, 60(7), 1013-1023.
[http://dx.doi.org/10.1002/glia.22288] [PMID: 22228580]
[56]
McCann, J.C.; Ames, B.N. Is docosahexaenoic acid, an n−3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am. J. Clin. Nutr., 2005, 82(2), 281-295.
[http://dx.doi.org/10.1093/ajcn/82.2.281] [PMID: 16087970]
[57]
Matute, C.; Domercq, M.; Sánchez-Gómez, M.V. Glutamate‐mediated glial injury: Mechanisms and clinical importance. Glia, 2006, 53(2), 212-224.
[http://dx.doi.org/10.1002/glia.20275] [PMID: 16206168]
[58]
Cotrina, M.L.; Nedergaard, M. Astrocytes in the aging brain. J. Neurosci. Res., 2002, 67(1), 1-10.
[http://dx.doi.org/10.1002/jnr.10121] [PMID: 11754075]
[59]
Dyall, S.C.; Michael, G.J.; Whelpton, R.; Scott, A.G.; Michael-Titus, A.T. Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain. Neurobiol. Aging, 2007, 28(3), 424-439.
[http://dx.doi.org/10.1016/j.neurobiolaging.2006.01.002] [PMID: 16500747]
[60]
Farooqui, A.A.; Horrocks, L.A.; Farooqui, T. Modulation of inflammation in brain: A matter of fat. J. Neurochem., 2007, 101(3), 577-599.
[http://dx.doi.org/10.1111/j.1471-4159.2006.04371.x] [PMID: 17257165]
[61]
Yi, J.H.; Hazell, A.S. Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury. Neurochem. Int., 2006, 48(5), 394-403.
[http://dx.doi.org/10.1016/j.neuint.2005.12.001] [PMID: 16473439]
[62]
Sheldon, A.L.; Robinson, M.B. The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention. Neurochem. Int., 2007, 51(6-7), 333-355.
[http://dx.doi.org/10.1016/j.neuint.2007.03.012] [PMID: 17517448]
[63]
Grintal, B.; Champeil-Potokar, G.; Lavialle, M.; Vancassel, S.; Breton, S.; Denis, I. Inhibition of astroglial glutamate transport by polyunsaturated fatty acids: Evidence for a signalling role of docosahexaenoic acid. Neurochem. Int., 2009, 54(8), 535-543.
[http://dx.doi.org/10.1016/j.neuint.2009.02.018] [PMID: 19428799]
[64]
Long, E.K.; Rosenberger, T.A.; Picklo, M.J., Sr Ethanol withdrawal increases glutathione adducts of 4-hydroxy-2-hexenal but not 4-hydroxyl-2-nonenal in the rat cerebral cortex. Free Radic. Biol. Med., 2010, 48(3), 384-390.
[http://dx.doi.org/10.1016/j.freeradbiomed.2009.10.048] [PMID: 19878718]
[65]
Haydon, P.G.; Carmignoto, G. Astrocyte control of synaptic transmission and neurovascular coupling. Physiol. Rev., 2006, 86(3), 1009-1031.
[http://dx.doi.org/10.1152/physrev.00049.2005] [PMID: 16816144]
[66]
Calder, P.C. Omega‐3 polyunsaturated fatty acids and inflammatory processes: Nutrition or pharmacology? Br. J. Clin. Pharmacol., 2013, 75(3), 645-662.
[http://dx.doi.org/10.1111/j.1365-2125.2012.04374.x] [PMID: 22765297]
[67]
Calder, P.C. Fatty acids and inflammation: The cutting edge between food and pharma. Eur. J. Pharmacol., 2011, 668(Suppl. 1), S50-S58.
[http://dx.doi.org/10.1016/j.ejphar.2011.05.085] [PMID: 21816146]
[68]
Orr, S.K.; Palumbo, S.; Bosetti, F.; Mount, H.T.; Kang, J.X.; Greenwood, C.E.; Ma, D.W.L.; Serhan, C.N.; Bazinet, R.P. Unesterified docosahexaenoic acid is protective in neuroinflammation. J. Neurochem., 2013, 127(3), 378-393.
[http://dx.doi.org/10.1111/jnc.12392] [PMID: 23919613]
[69]
Chang, C.L.; Deckelbaum, R.J. Omega-3 fatty acids. Curr. Opin. Lipidol., 2013, 24(4), 345-350.
[http://dx.doi.org/10.1097/MOL.0b013e3283616364] [PMID: 23594712]
[70]
Musiek, E.S.; Brooks, J.D.; Joo, M.; Brunoldi, E.; Porta, A.; Zanoni, G.; Vidari, G.; Blackwell, T.S.; Montine, T.J.; Milne, G.L.; McLaughlin, B.; Morrow, J.D. Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. J. Biol. Chem., 2008, 283(29), 19927-19935.
[http://dx.doi.org/10.1074/jbc.M803625200] [PMID: 18490445]
[71]
Eckert, G.P.; Lipka, U.; Muller, W.E. Omega-3 fatty acids in neurodegenerative diseases: Focus on mitochondria. Prostaglandins Leukot. Essent. Fatty Acids, 2013, 88(1), 105-114.
[http://dx.doi.org/10.1016/j.plefa.2012.05.006] [PMID: 22727983]
[72]
Denis, I.; Potier, B.; Heberden, C.; Vancassel, S. ω-3 polyunsaturated fatty acids and brain aging. Curr. Opin. Clin. Nutr. Metab. Care, 2015, 18(2), 139-146.
[http://dx.doi.org/10.1097/MCO.0000000000000141] [PMID: 25501348]
[73]
Haast, R.A.M.; Kiliaan, A.J. Impact of fatty acids on brain circulation, structure and function. Prostaglandins Leukot. Essent. Fatty Acids, 2015, 92, 3-14.
[http://dx.doi.org/10.1016/j.plefa.2014.01.002] [PMID: 24485516]
[74]
Ximenes da Silva, A.; Lavialle, F.; Gendrot, G.; Guesnet, P.; Alessandri, J.M.; Lavialle, M. Glucose transport and utilization are altered in the brain of rats deficient in n-3 polyunsaturated fatty acids. J. Neurochem., 2002, 81(6), 1328-1337.
[http://dx.doi.org/10.1046/j.1471-4159.2002.00932.x] [PMID: 12068080]
[75]
Pifferi, F.; Roux, F.; Langelier, B.; Alessandri, J.M.; Vancassel, S.; Jouin, M.; Lavialle, M.; Guesnet, P. (n-3) polyunsaturated fatty acid deficiency reduces the expression of both isoforms of the brain glucose transporter GLUT1 in rats. J. Nutr., 2005, 135(9), 2241-2246.
[http://dx.doi.org/10.1093/jn/135.9.2241] [PMID: 16140905]
[76]
Cunnane, S.C.; Plourde, M.; Pifferi, F.; Bégin, M.; Féart, C.; Barberger-Gateau, P. Fish, docosahexaenoic acid and Alzheimer’s disease. Prog. Lipid Res., 2009, 48(5), 239-256.
[http://dx.doi.org/10.1016/j.plipres.2009.04.001] [PMID: 19362576]
[77]
Bennett, D.A.; Arnold, S.E.; Valenzuela, M.J.; Brayne, C.; Schneider, J.A. Cognitive and social lifestyle: Links with neuropathology and cognition in late life. Acta Neuropathol., 2014, 127(1), 137-150.
[http://dx.doi.org/10.1007/s00401-013-1226-2] [PMID: 24356982]
[78]
Titova, O.E.; Sjögren, P.; Brooks, S.J.; Kullberg, J.; Ax, E.; Kilander, L.; Riserus, U.; Cederholm, T.; Larsson, E.M.; Johansson, L.; Ahlström, H.; Lind, L.; Schiöth, H.B.; Benedict, C. Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly. Age, 2013, 35(4), 1495-1505.
[http://dx.doi.org/10.1007/s11357-012-9453-3] [PMID: 22791395]
[79]
Mazereeuw, G.; Lanctôt, K.L.; Chau, S.A.; Swardfager, W.; Herrmann, N. Effects of ω-3 fatty acids on cognitive performance: A meta-analysis. Neurobiol. Aging, 2012, 33(7), 1482.e17-1482.e29.
[http://dx.doi.org/10.1016/j.neurobiolaging.2011.12.014] [PMID: 22305186]
[80]
Barberger-Gateau, P.; Letenneur, L.; Deschamps, V.; Pérès, K.; Dartigues, J.F.; Renaud, S. Fish, meat, and risk of dementia: Cohort study. BMJ, 2002, 325(7370), 932-933.
[http://dx.doi.org/10.1136/bmj.325.7370.932] [PMID: 12399342]
[81]
Mischoulon, D.; Fava, M. Docosahexanoic acid and ω-3 fatty acids in depression. Psychiatr. Clin. North Am., 2000, 23(4), 785-794.
[http://dx.doi.org/10.1016/S0193-953X(05)70197-0] [PMID: 11147247]
[82]
Block, E.R.; Edwards, D. Effect of plasma membrane fluidity on serotonin transport by endothelial cells. Am. J. Physiol. Cell Physiol., 1987, 253(5), C672-C678.
[http://dx.doi.org/10.1152/ajpcell.1987.253.5.C672] [PMID: 3688215]
[83]
Hibbeln, J.R. Fish consumption and major depression. Lancet, 1998, 351(9110), 1213.
[http://dx.doi.org/10.1016/S0140-6736(05)79168-6] [PMID: 9643729]
[84]
Yehuda, S.; Rabinovitz, S.; Mostofsky, D.I. Essential fatty acids and the brain: From infancy to aging. Neurobiol. Aging, 2005, 26(1), 98-102.
[http://dx.doi.org/10.1016/j.neurobiolaging.2005.09.013] [PMID: 16226347]
[85]
Dijck-Brouwer, D.A.J.; Hadders-Algra, M.; Bouwstra, H.; Decsi, T.; Boehm, G.; Martini, I.A.; Boersma, E.R.; Muskiet, F.A.J. Lower fetal status of docosahexaenoic acid, arachidonic acid and essential fatty acids is associated with less favorable neonatal neurological condition. Prostaglandins Leukot. Essent. Fatty Acids, 2005, 72(1), 21-28.
[http://dx.doi.org/10.1016/j.plefa.2004.08.002] [PMID: 15589396]
[86]
Mathai, M.L.; Soueid, M.; Chen, N.; Jayasooriya, A.P.; Sinclair, A.J.; Wlodek, M.E.; Weisinger, H.S.; Weisinger, R.S. Does perinatal ω-3 polyunsaturated fatty acid deficiency increase appetite signaling? Obes. Res., 2004, 12(11), 1886-1894.
[http://dx.doi.org/10.1038/oby.2004.234] [PMID: 15601986]
[87]
Farooqui, A.A.; Horrocks, L.A. Plasmalogens, phospholipase A2, and docosahexaenoic acid turnover in brain tissue. J. Mol. Neurosci., 2001, 16(2-3), 263-272.
[http://dx.doi.org/10.1385/JMN:16:2-3:263] [PMID: 11478381]
[88]
Keservani, R.K.; Kesharwani, R.K.; Sharma, A.K.; Ahmad, M.; Fasih, M. Stress, Parkinson’s, and Alzheimer’s Disease Role of Dietary Supplements, Nutraceuticals and Functional Foods in Human Health and Disease Prevention 2016, , 241-251.
[89]
Seshadri, S.; Beiser, A.; Selhub, J.; Jacques, P.F.; Rosenberg, I.H.; D’Agostino, R.B.; Wilson, P.W.F.; Wolf, P.A. Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease. N. Engl. J. Med., 2002, 346(7), 476-483.
[http://dx.doi.org/10.1056/NEJMoa011613] [PMID: 11844848]
[90]
Kalmijn, S.; Feskens, E.J.M.; Launer, L.J.; Kromhout, D. Polyunsaturated fatty acids, antioxidants, and cognitive function in very old men. Am. J. Epidemiol., 1997, 145(1), 33-41.
[http://dx.doi.org/10.1093/oxfordjournals.aje.a009029] [PMID: 8982020]
[91]
Conquer, J.A.; Tierney, M.C.; Zecevic, J.; Bettger, W.J.; Fisher, R.H. Fatty acid analysis of blood plasma of patients with alzheimer’s disease, other types of dementia, and cognitive impairment. Lipids, 2000, 35(12), 1305-1312.
[http://dx.doi.org/10.1007/s11745-000-0646-3] [PMID: 11201991]
[92]
Swanson, D.; Block, R.; Mousa, S.A. Omega-3 fatty acids EPA and DHA: Health benefits throughout life. Adv. Nutr., 2012, 3(1), 1-7.
[http://dx.doi.org/10.3945/an.111.000893] [PMID: 22332096]
[93]
Keservani, R.K.; Kesharwani, R.K.; Sharma, A.K.; Vyas, N.; Chadoker, A. Nutritional supplements: An overview. Int. J. Curr. Pharm Rev. Res., 2010, 1, 59-75.
[94]
Chen, H.; Tappel, A.L. Vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q, beta-carotene, canthaxanthin, and (+)-catechin protect against oxidative damage to kidney, heart, lung and spleen. Free Radic. Res., 1995, 22(2), 177-186.
[http://dx.doi.org/10.3109/10715769509147537] [PMID: 7704186]
[95]
Nagamatsu, M.; Nickander, K.K.; Schmelzer, J.D.; Raya, A.; Wittrock, D.A.; Tritschler, H.; Low, P.A. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care, 1995, 18(8), 1160-1167.
[http://dx.doi.org/10.2337/diacare.18.8.1160] [PMID: 7587852]
[96]
Pandya, C.D.; Howell, K.R.; Pillai, A. Antioxidants as potential therapeutics for neuropsychiatric disorders. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2013, 46, 214-223.
[http://dx.doi.org/10.1016/j.pnpbp.2012.10.017] [PMID: 23123357]
[97]
Khajehnasiri, F.; Mortazavi, S.B.; Allameh, A.; Akhondzadeh, S. Effect of omega-3 and ascorbic acid on inflammation markers in depressed shift workers in Shahid Tondgoyan Oil Refinery, Iran: A randomized double-blind placebo-controlled study. J. Clin. Biochem. Nutr., 2013, 53(1), 36-40.
[http://dx.doi.org/10.3164/jcbn.12-98] [PMID: 23874068]
[98]
Skulas-Ray, A.C.; Wilson, P.W.F.; Harris, W.S.; Brinton, E.A.; Kris-Etherton, P.M.; Richter, C.K.; Jacobson, T.A.; Engler, M.B.; Miller, M.; Robinson, J.G.; Blum, C.B.; Rodriguez-Leyva, D.; de Ferranti, S.D.; Welty, F.K. Omega-3 Fatty Acids for the Management of Hypertriglyceridemia A Science Advisory From the American Heart Association. Circulation, 2019, 140(12), e673-e691.
[http://dx.doi.org/10.1161/CIR.0000000000000709] [PMID: 31422671]
[99]
Brinton, E.A.; Mason, R.P. Prescription omega-3 fatty acid products containing highly purified eicosapentaenoic acid (EPA). Lipids Health Dis., 2017, 16(1), 23.
[http://dx.doi.org/10.1186/s12944-017-0415-8] [PMID: 28137294]
[100]
Fabian, C.J.; Kimler, B.F.; Hursting, S.D. Omega-3 fatty acids for breast cancer prevention and survivorship. Breast Cancer Res., 2015, 17(1), 62.
[http://dx.doi.org/10.1186/s13058-015-0571-6] [PMID: 25936773]
[101]
Fialkow, J. Omega-3 Fatty Acid Formulations in Cardiovascular Disease: Dietary Supplements are Not Substitutes for Prescription Products. Am. J. Cardiovasc. Drugs, 2016, 16(4), 229-239.
[http://dx.doi.org/10.1007/s40256-016-0170-7] [PMID: 27138439]
[102]
Ito, MK A Comparative Overview of Prescription Omega-3 Fatty Acid Products. P T. journal, 2015, 40(12), 826-857.
[103]
Nabavi, S.F.; Bilotto, S.; Russo, G.L.; Orhan, I.E.; Habtemariam, S.; Daglia, M.; Devi, K.P.; Loizzo, M.R.; Tundis, R.; Nabavi, S.M. Omega-3 polyunsaturated fatty acids and cancer: Lessons learned from clinical trials. Cancer Metastasis Rev., 2015, 34(3), 359-380.
[http://dx.doi.org/10.1007/s10555-015-9572-2] [PMID: 26227583]
[104]
Saccone, G.; Berghella, V. Omega-3 long chain polyunsaturated fatty acids to prevent preterm birth: A systematic review and meta-analysis. Obstet. Gynecol., 2015, 125(3), 663-672.
[http://dx.doi.org/10.1097/AOG.0000000000000668] [PMID: 25730231]
[105]
García-Hernández, J.; Ortega-Vélez, M.I.; Contreras-Paniagua, A.D.; Aguilera-Márquez, D.; Leyva-García, G.; Torre, J. Mercury concentrations in seafood and the associated risk in women with high fish consumption from coastal villages of Sonora, Mexico. Food Chem. Toxicol., 2018, 120, 367-377.
[http://dx.doi.org/10.1016/j.fct.2018.07.029] [PMID: 30026089]
[106]
Is excessive consumption of omega-3 fatty acids bad for you? Available From: https://www.ndtv.com/health/is-excessive-consumption-of-omega-3-fatty-acids-bad-for-you-1936803 (Accessed on 14 September 2023).
[107]
Indiamart Available From: https://dir.indiamart.com/search.mp?ss=omega3+&prdsrc=1&mcatid=203861&catid=578&stype=attr=1
[108]
Amway, Nutrilite Available From: https://www.amway.in/amway-brands/nutrilite

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