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Current Signal Transduction Therapy

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ISSN (Print): 1574-3624
ISSN (Online): 2212-389X

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Mini-Review Article

The Regulatory Role of Circular RNAs as miRNA Sponges in Cervical Cancer

Author(s): Sajad Najafi, Farhoodeh Ghaedrahmati, Mahrokh Abouali Gale Dari, Maryam Farzaneh* and Razieh Mohammad Jafari

Volume 18, Issue 3, 2023

Published on: 24 November, 2023

Article ID: e241123223777 Pages: 9

DOI: 10.2174/0115743624273536231105142321

Price: $65

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Abstract

Cervical cancer is ranked as the fourth most frequently diagnosed cancer and the fourth leading cause of cancer-related deaths among females. Cervical cancer is a complex disease influenced by various genetic, epigenetic, and environmental factors. While treatment options such as radiotherapy, chemotherapy, and hormonal therapy exist, the prognosis remains poor due to high rates of distant and lymphatic metastasis. Recent research has shed light on the role of non-coding RNAs (ncRNAs) in cervical cancer development, with circular RNAs (circRNAs) emerging as a potentially significant regulator of cellular processes. Through targeting miRNAs/mRNAs, circRNAs can impact cell growth and invasion in cervical cancer cells, making them a promising biomarker for diagnosis and treatment. This review provides an overview of the functional roles of circRNAs in the context of cervical cancer.

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