Abstract
Receptor tyrosine kinase (RTK) regulates multiple pathways, including Mitogenactivated protein kinases (MAPKs), PI3/AKT, JAK/STAT pathway, etc. which has a significant role in the progression and metastasis of tumor. As RTK activation regulates numerous essential bodily processes, including cell proliferation and division, RTK dysregulation has been identified in many types of cancers. Targeting RTK is a significant challenge in cancer due to the abnormal upregulation and downregulation of RTK receptors subfamily EGFR, FGFR, PDGFR, VEGFR, and HGFR in the progression of cancer, which is governed by multiple RTK receptor signalling pathways and impacts treatment response and disease progression. In this review, an extensive focus has been carried out on the normal and abnormal signalling pathways of EGFR, FGFR, PDGFR, VEGFR, and HGFR and their association with cancer initiation and progression. These are explored as potential therapeutic cancer targets and therefore, the inhibitors were evaluated alone and merged with additional therapies in clinical trials aimed at combating global cancer.
Graphical Abstract
[http://dx.doi.org/10.1016/j.cell.2011.02.013] [PMID: 21376230]
[http://dx.doi.org/10.2174/0929867328666210303101345] [PMID: 33655823]
[http://dx.doi.org/10.1186/s12943-018-0782-4] [PMID: 29455648]
[http://dx.doi.org/10.1016/j.ijrobp.2003.11.041]
[http://dx.doi.org/10.1126/science.7997877] [PMID: 7997877]
[http://dx.doi.org/10.1046/j.1365-2184.2003.00267.x] [PMID: 12814432]
[http://dx.doi.org/10.2741/A281] [PMID: 9512454]
[http://dx.doi.org/10.1016/S0195-5616(97)50005-2] [PMID: 9002166]
[http://dx.doi.org/10.1006/scbi.1995.0007] [PMID: 7548842]
[http://dx.doi.org/10.1126/science.2683079] [PMID: 2683079]
[http://dx.doi.org/10.1016/j.radi.2006.12.001]
[http://dx.doi.org/10.1016/0092-8674(94)90543-6] [PMID: 7954824]
[http://dx.doi.org/10.5483/BMBRep.2003.36.1.060] [PMID: 12542976]
[http://dx.doi.org/10.1016/S0168-9525(00)89027-7] [PMID: 7732591]
[http://dx.doi.org/10.1046/j.1365-2184.2003.00266.x] [PMID: 12814430]
[http://dx.doi.org/10.1371/journal.pone.0094508] [PMID: 24728073]
[http://dx.doi.org/10.1038/sj.bjc.6603615] [PMID: 17375037]
[http://dx.doi.org/10.1016/0092-8674(94)90541-X] [PMID: 7954822]
[http://dx.doi.org/10.1038/350512a0] [PMID: 1826542]
[http://dx.doi.org/10.1126/science.7652577] [PMID: 7652577]
[http://dx.doi.org/10.1186/s43042-019-0035-0]
[http://dx.doi.org/10.1038/sj.onc.1202171]
[http://dx.doi.org/10.1126/science.1075762] [PMID: 12471243]
[http://dx.doi.org/10.7150/ijms.1.101] [PMID: 15912202]
[http://dx.doi.org/10.1146/annurev.bi.62.070193.002321] [PMID: 7688944]
[http://dx.doi.org/10.1146/annurev.cb.10.110194.001343] [PMID: 7888178]
[http://dx.doi.org/10.1016/j.cytogfr.2005.01.001] [PMID: 15863030]
[http://dx.doi.org/10.1006/excr.1999.4732] [PMID: 10623460]
[http://dx.doi.org/10.1038/bjc.2015.233] [PMID: 26151455]
[http://dx.doi.org/10.1038/35077225] [PMID: 11357143]
[http://dx.doi.org/10.1016/S0168-9525(00)02021-7] [PMID: 10827454]
[http://dx.doi.org/10.1021/bi00379a035] [PMID: 3494473]
[http://dx.doi.org/10.1038/276409a0] [PMID: 309559]
[http://dx.doi.org/10.1016/S0014-4827(02)00099-X] [PMID: 12648469]
[http://dx.doi.org/10.1016/S0360-3016(01)01609-1] [PMID: 11567815]
[http://dx.doi.org/10.1126/science.2470152] [PMID: 2470152]
[http://dx.doi.org/10.1016/S0163-7258(98)00050-3] [PMID: 10454198]
[http://dx.doi.org/10.1016/S0065-230X(08)60784-8] [PMID: 10549355]
[http://dx.doi.org/10.1053/j.seminoncol.2006.04.003] [PMID: 16890793]
[http://dx.doi.org/10.1038/nrc1609] [PMID: 15864276]
[http://dx.doi.org/10.1038/35052073] [PMID: 11252954]
[http://dx.doi.org/10.1159/000279388] [PMID: 20130423]
[http://dx.doi.org/10.1158/1078-0432.CCR-16-0934] [PMID: 28087641]
[http://dx.doi.org/10.1021/acs.chemrev.7b00105] [PMID: 28541680]
[http://dx.doi.org/10.1371/journal.pone.0103203] [PMID: 25062045]
[http://dx.doi.org/10.1016/S0014-4827(02)00102-7] [PMID: 12648463]
[http://dx.doi.org/10.1016/0092-8674(84)90550-6] [PMID: 6088071]
[http://dx.doi.org/10.1126/science.2466334] [PMID: 2466334]
[http://dx.doi.org/10.1126/science.1840698] [PMID: 1840698]
[http://dx.doi.org/10.1006/bbrc.1993.1173] [PMID: 8439318]
[http://dx.doi.org/10.1074/jbc.270.13.7495] [PMID: 7706296]
[http://dx.doi.org/10.1074/jbc.M006935200] [PMID: 11278323]
[http://dx.doi.org/10.1093/oxfordjournals.jbchem.a021806] [PMID: 9348101]
[http://dx.doi.org/10.1038/sj.onc.1205960] [PMID: 12466964]
[http://dx.doi.org/10.1006/bbrc.1999.1873] [PMID: 10600548]
[http://dx.doi.org/10.1016/j.bbrc.2004.07.066] [PMID: 15358134]
[http://dx.doi.org/10.1016/j.cell.2010.06.011] [PMID: 20602996]
[http://dx.doi.org/10.1016/S1097-2765(03)00047-9] [PMID: 12620237]
[http://dx.doi.org/10.1016/j.cell.2006.05.013] [PMID: 16777603]
[http://dx.doi.org/10.1016/j.cell.2009.04.025] [PMID: 19563760]
[http://dx.doi.org/10.1073/pnas.86.3.925] [PMID: 2915986]
[http://dx.doi.org/10.1128/mcb.12.3.981-990.1992] [PMID: 1372091]
[http://dx.doi.org/10.1016/0092-8674(92)90167-B] [PMID: 1322798]
[http://dx.doi.org/10.1016/j.tcb.2013.11.002] [PMID: 24295852]
[http://dx.doi.org/10.1074/jbc.RA120.013639] [PMID: 32467228]
[http://dx.doi.org/10.1016/1040-8428(94)00144-I] [PMID: 7612182]
[http://dx.doi.org/10.1002/jso.2930510304] [PMID: 1434639]
[http://dx.doi.org/10.1128/mcb.14.8.5192-5201.1994] [PMID: 7518560]
[http://dx.doi.org/10.1016/S0021-9258(17)41718-2] [PMID: 8307946]
[http://dx.doi.org/10.1016/S0898-6568(01)00192-9] [PMID: 11583913]
[http://dx.doi.org/10.1016/0092-8674(95)90403-4] [PMID: 7834740]
[http://dx.doi.org/10.1126/scisignal.aax2364] [PMID: 32127496]
[http://dx.doi.org/10.1146/annurev-med-062913-051343] [PMID: 26473415]
[http://dx.doi.org/10.1152/ajpgi.00253.2004] [PMID: 15284024]
[http://dx.doi.org/10.1074/jbc.M207289200] [PMID: 12429742]
[http://dx.doi.org/10.1126/science.277.5332.1630] [PMID: 9287210]
[http://dx.doi.org/10.1126/science.8140422] [PMID: 8140422]
[http://dx.doi.org/10.1038/nrc1275] [PMID: 14964307]
[http://dx.doi.org/10.1038/sj.onc.1203527] [PMID: 10851046]
[http://dx.doi.org/10.1038/ncponc0195] [PMID: 16264989]
[http://dx.doi.org/10.1172/JCI0215617] [PMID: 11994401]
[http://dx.doi.org/10.1038/307521a0] [PMID: 6320011]
[http://dx.doi.org/10.1016/S0021-9258(19)85758-7] [PMID: 6245088]
[http://dx.doi.org/10.1158/1078-0432.CCR-05-1554] [PMID: 17000658]
[http://dx.doi.org/10.1126/science.3798106] [PMID: 3798106]
[http://dx.doi.org/10.1002/jcb.28782] [PMID: 31037763]
[http://dx.doi.org/10.1038/nrc3309] [PMID: 22785351]
[http://dx.doi.org/10.1126/science.1099314] [PMID: 15118125]
[http://dx.doi.org/10.1056/NEJMoa040938] [PMID: 15118073]
[http://dx.doi.org/10.1016/j.ccr.2013.04.012] [PMID: 23680147]
[http://dx.doi.org/10.1002/gcc.1146] [PMID: 11391800]
[http://dx.doi.org/10.1038/ng.438] [PMID: 19718025]
[http://dx.doi.org/10.1073/pnas.0405220101] [PMID: 15329413]
[http://dx.doi.org/10.1073/pnas.87.21.8602]
[http://dx.doi.org/10.1016/j.ceb.2008.12.010] [PMID: 19208461]
[http://dx.doi.org/10.1002/ijc.21496] [PMID: 16231326]
[http://dx.doi.org/10.1016/j.ccr.2006.06.012] [PMID: 16843261]
[http://dx.doi.org/10.1016/j.yexcr.2008.07.026] [PMID: 18721806]
[http://dx.doi.org/10.3390/ijms22020587] [PMID: 33435537]
[PMID: 12036928]
[http://dx.doi.org/10.1073/pnas.0409773102] [PMID: 15731348]
[http://dx.doi.org/10.1073/pnas.1537685100] [PMID: 12853564]
[http://dx.doi.org/10.1158/0008-5472.CAN-05-1977] [PMID: 16357156]
[http://dx.doi.org/10.1007/s10911-008-9079-3] [PMID: 18454307]
[http://dx.doi.org/10.1002/path.1335] [PMID: 12845622]
[http://dx.doi.org/10.1016/S1050-1738(01)00065-2] [PMID: 11343971]
[http://dx.doi.org/10.1038/s41568-020-00322-0] [PMID: 33462501]
[http://dx.doi.org/10.3389/fonc.2019.00800] [PMID: 31508364]
[http://dx.doi.org/10.1126/scisignal.287re6] [PMID: 19738203]
[http://dx.doi.org/10.1038/nrc3918] [PMID: 25855404]
[http://dx.doi.org/10.1369/jhc.2010.955104] [PMID: 20159766]
[http://dx.doi.org/10.1158/1078-0432.CCR-17-0890] [PMID: 28855349]
[http://dx.doi.org/10.1093/neuonc/nox167] [PMID: 29059447]
[http://dx.doi.org/10.1038/s41388-020-1208-5] [PMID: 32066879]
[http://dx.doi.org/10.1186/s12885-019-6177-0] [PMID: 31623593]
[http://dx.doi.org/10.2353/ajpath.2007.070011] [PMID: 17456751]
[http://dx.doi.org/10.1111/j.1750-3639.1996.tb00848.x] [PMID: 8864278]
[http://dx.doi.org/10.1038/ncb1567] [PMID: 17450133]
[http://dx.doi.org/10.1093/neuonc/noy058] [PMID: 29660021]
[PMID: 16167544]
[http://dx.doi.org/10.12688/f1000research.9025.1]
[http://dx.doi.org/10.1158/0008-5472.CAN-05-2753] [PMID: 16424019]
[http://dx.doi.org/10.1023/A:1005824802617] [PMID: 9440027]
[PMID: 8455929]
[http://dx.doi.org/10.1016/S0960-9822(95)00102-3] [PMID: 7583099]
[http://dx.doi.org/10.1097/00006676-199808000-00010] [PMID: 9700949]
[http://dx.doi.org/10.1210/jcem.82.4.3896] [PMID: 9100589]
[http://dx.doi.org/10.1182/blood.V92.9.3025] [PMID: 9787135]
[http://dx.doi.org/10.1038/ng0797-260] [PMID: 9207791]
[http://dx.doi.org/10.1182/blood.V90.10.4062] [PMID: 9354676]
[http://dx.doi.org/10.1182/blood.V97.3.729] [PMID: 11157491]
[PMID: 11325814]
[http://dx.doi.org/10.1038/12615] [PMID: 10471491]
[http://dx.doi.org/10.1038/sj.ejhg.5200883] [PMID: 12461689]
[http://dx.doi.org/10.1016/j.tig.2004.08.007] [PMID: 15475116]
[http://dx.doi.org/10.1002/(SICI)1521-1878(200002)22:2<108:AID-BIES2>3.0.CO;2-M] [PMID: 10655030]
[http://dx.doi.org/10.1016/S0065-230X(08)60821-0] [PMID: 8417497]
[http://dx.doi.org/10.1126/science.8456318] [PMID: 8456318]
[http://dx.doi.org/10.1016/j.str.2011.10.022] [PMID: 22244757]
[http://dx.doi.org/10.1016/j.cytogfr.2005.01.008] [PMID: 15863029]
[http://dx.doi.org/10.1158/1078-0432.CCR-11-0699] [PMID: 22388515]
[http://dx.doi.org/10.1016/S0378-1119(01)00518-2] [PMID: 11418238]
[http://dx.doi.org/10.1016/0303-7207(86)90001-8] [PMID: 2427371]
[http://dx.doi.org/10.1002/wdev.176] [PMID: 25772309]
[http://dx.doi.org/10.1038/nrc2780] [PMID: 20094046]
[http://dx.doi.org/10.2741/3007] [PMID: 18508513]
[http://dx.doi.org/10.1016/j.jmb.2004.04.031] [PMID: 15165853]
[http://dx.doi.org/10.1016/j.molcel.2006.01.022] [PMID: 16507368]
[http://dx.doi.org/10.1158/0008-5472.CAN-09-3033] [PMID: 20388777]
[http://dx.doi.org/10.1128/MCB.20.3.979-989.2000]
[http://dx.doi.org/10.1016/S0092-8674(00)80252-4] [PMID: 9182757]
[http://dx.doi.org/10.1016/S0092-8674(00)00114-8] [PMID: 11057895]
[http://dx.doi.org/10.1006/dbio.2002.0696] [PMID: 12086464]
[http://dx.doi.org/10.1126/stke.2282004pe17] [PMID: 15082862]
[http://dx.doi.org/10.1128/MCB.24.13.5657-5666.2004] [PMID: 15199124]
[http://dx.doi.org/10.1073/pnas.94.23.12419]
[http://dx.doi.org/10.1126/science.296.5573.1655] [PMID: 12040186]
[http://dx.doi.org/10.1016/j.cell.2007.06.009] [PMID: 17604717]
[http://dx.doi.org/10.1038/ncb840] [PMID: 12172554]
[http://dx.doi.org/10.1038/ncb839] [PMID: 12172553]
[http://dx.doi.org/10.1038/358678a0] [PMID: 1379697]
[http://dx.doi.org/10.2741/Klint] [PMID: 9989949]
[http://dx.doi.org/10.1074/jbc.M111.254631] [PMID: 22199350]
[http://dx.doi.org/10.1038/sj.onc.1203650] [PMID: 10918587]
[http://dx.doi.org/10.1074/jbc.M308743200] [PMID: 14660670]
[http://dx.doi.org/10.1038/nature05610] [PMID: 17344846]
[http://dx.doi.org/10.1073/pnas.0803379105] [PMID: 18552176]
[http://dx.doi.org/10.1172/JCI39703] [PMID: 19809159]
[PMID: 9331099]
[http://dx.doi.org/10.1083/jcb.200107119] [PMID: 12011115]
[http://dx.doi.org/10.1126/scitranslmed.3001451] [PMID: 21160078]
[http://dx.doi.org/10.1158/0008-5472.CAN-07-5229] [PMID: 18381441]
[http://dx.doi.org/10.1016/j.oraloncology.2006.01.005] [PMID: 16807070]
[PMID: 11389083]
[http://dx.doi.org/10.1158/1078-0432.CCR-07-0502] [PMID: 17699850]
[http://dx.doi.org/10.1016/j.humpath.2009.11.003] [PMID: 20226962]
[http://dx.doi.org/10.1172/JCI38017] [PMID: 19381019]
[PMID: 11454700]
[http://dx.doi.org/10.1111/j.1440-1746.2005.03726.x] [PMID: 15836707]
[http://dx.doi.org/10.1128/MCB.18.10.6063] [PMID: 9742123]
[http://dx.doi.org/10.1016/S0168-8278(97)80085-2] [PMID: 9365044]
[http://dx.doi.org/10.1002/hep.24099] [PMID: 21319186]
[http://dx.doi.org/10.1016/S0002-9440(10)61177-7] [PMID: 12057932]
[http://dx.doi.org/10.1016/j.ccr.2011.01.040] [PMID: 21397858]
[http://dx.doi.org/10.1124/mol.108.049544] [PMID: 18849352]
[http://dx.doi.org/10.1038/nm0897-887] [PMID: 9256280]
[PMID: 12433733]
[http://dx.doi.org/10.1038/sj.emboj.7601198] [PMID: 16810323]
[http://dx.doi.org/10.1016/j.cytogfr.2005.01.004] [PMID: 15863032]
[http://dx.doi.org/10.1200/JCO.2006.09.0795]
[http://dx.doi.org/10.1074/jbc.M601252200] [PMID: 16597617]
[http://dx.doi.org/10.1042/BJ20101603] [PMID: 21711248]
[http://dx.doi.org/10.1038/nature05887] [PMID: 17529967]
[http://dx.doi.org/10.1371/journal.pgen.1000054] [PMID: 18437204]
[http://dx.doi.org/10.3892/or.14.2.415] [PMID: 16012724]
[http://dx.doi.org/10.1074/jbc.M803998200] [PMID: 19103595]
[http://dx.doi.org/10.1073/pnas.2237184100] [PMID: 14699054]
[http://dx.doi.org/10.1038/nrc2521] [PMID: 18948996]
[http://dx.doi.org/10.1016/j.drup.2005.03.004] [PMID: 15939344]
[http://dx.doi.org/10.1007/s00018-020-03753-y] [PMID: 33449152]
[http://dx.doi.org/10.1042/BST20200004] [PMID: 32369556]
[http://dx.doi.org/10.1038/35010579] [PMID: 10806482]
[http://dx.doi.org/10.1038/35074588] [PMID: 11331881]
[http://dx.doi.org/10.1016/j.cytogfr.2004.03.007] [PMID: 15207811]
[http://dx.doi.org/10.1038/320695a0] [PMID: 3754619]
[http://dx.doi.org/10.1161/01.CIR.103.18.2242] [PMID: 11342471]
[http://dx.doi.org/10.1016/B978-0-12-803581-8.10191-2]
[http://dx.doi.org/10.1016/j.gene.2017.03.003] [PMID: 28267575]
[http://dx.doi.org/10.1016/S1556-0864(15)31506-9] [PMID: 17409820]
[http://dx.doi.org/10.4049/jimmunol.160.10.5018] [PMID: 9590251]
[http://dx.doi.org/10.1515/hsz-2014-0257] [PMID: 25781681]
[http://dx.doi.org/10.3892/mmr.2017.7641] [PMID: 28983598]
[http://dx.doi.org/10.3390/cancers7030860] [PMID: 26404379]
[http://dx.doi.org/10.1074/jbc.M212803200] [PMID: 12865432]
[http://dx.doi.org/10.1046/j.0022-3042.2001.00699.x] [PMID: 11902114]
[http://dx.doi.org/10.1186/scrt32] [PMID: 20977782]
[http://dx.doi.org/10.1016/B978-0-12-819460-7.00251-6]
[http://dx.doi.org/10.1016/j.cell.2017.04.001] [PMID: 28431241]
[http://dx.doi.org/10.1038/ng0497-356] [PMID: 9090379]
[PMID: 20424265]
[http://dx.doi.org/10.1152/ajplung.00315.2001] [PMID: 12003786]
[http://dx.doi.org/10.1074/jbc.M406922200] [PMID: 15322111]
[http://dx.doi.org/10.1016/j.jhep.2009.03.024] [PMID: 19457567]
[http://dx.doi.org/10.1101/gad.1653708] [PMID: 18483217]
[http://dx.doi.org/10.1126/science.277.5323.242] [PMID: 9211853]
[http://dx.doi.org/10.1101/gad.8.16.1888] [PMID: 7958864]
[http://dx.doi.org/10.1038/s41467-018-06949-w] [PMID: 30389923]
[http://dx.doi.org/10.1038/onc.2013.218] [PMID: 23752188]
[http://dx.doi.org/10.1200/JCO.2005.14.068] [PMID: 15928335]
[http://dx.doi.org/10.1038/labinvest.3700360] [PMID: 16258521]
[http://dx.doi.org/10.1016/j.critrevonc.2016.11.008] [PMID: 28010895]
[PMID: 23976869]
[http://dx.doi.org/10.1111/j.1582-4934.2011.01415.x] [PMID: 21854543]
[http://dx.doi.org/10.1182/blood-2010-04-279752] [PMID: 20581310]
[http://dx.doi.org/10.1182/blood-2015-09-670166] [PMID: 26872634]
[http://dx.doi.org/10.1177/1947601911423031] [PMID: 22866201]
[http://dx.doi.org/10.1038/nature04483] [PMID: 16355214]
[http://dx.doi.org/10.1038/nature10144] [PMID: 21593862]
[http://dx.doi.org/10.1042/CS20040370] [PMID: 16104843]
[http://dx.doi.org/10.1146/annurev.bb.24.060195.001413] [PMID: 7663117]
[http://dx.doi.org/10.1073/pnas.94.14.7192] [PMID: 9207067]
[http://dx.doi.org/10.1016/S0969-2126(97)00284-0] [PMID: 9351807]
[PMID: 2158038]
[http://dx.doi.org/10.1159/000133341] [PMID: 1324138]
[http://dx.doi.org/10.1038/ncb0102-e2] [PMID: 11780131]
[http://dx.doi.org/10.1126/science.1312256] [PMID: 1312256]
[http://dx.doi.org/10.1016/S0021-9258(18)47298-5] [PMID: 7929268]
[http://dx.doi.org/10.1073/pnas.95.20.11709] [PMID: 9751730]
[http://dx.doi.org/10.1002/j.1460-2075.1996.tb00872.x] [PMID: 8890165]
[http://dx.doi.org/10.1016/0006-291X(92)90483-2] [PMID: 1417831]
[http://dx.doi.org/10.1038/376062a0] [PMID: 7596435]
[http://dx.doi.org/10.1074/jbc.270.12.6729] [PMID: 7896817]
[http://dx.doi.org/10.1038/sj.onc.1202527] [PMID: 10327068]
[http://dx.doi.org/10.1074/jbc.271.10.5761] [PMID: 8621443]
[http://dx.doi.org/10.1038/nm0603-669] [PMID: 12778165]
[http://dx.doi.org/10.1016/S0092-8674(00)81402-6] [PMID: 9529250]
[http://dx.doi.org/10.1016/S1050-1738(01)00140-2] [PMID: 11796239]
[http://dx.doi.org/10.1242/dev.126.21.4895] [PMID: 10518505]
[http://dx.doi.org/10.1073/pnas.162366299] [PMID: 12142468]
[http://dx.doi.org/10.1007/s12079-016-0352-8] [PMID: 27619687]
[http://dx.doi.org/10.1210/edrv.18.1.0287] [PMID: 9034784]
[http://dx.doi.org/10.1126/science.6823562] [PMID: 6823562]
[PMID: 7538264]
[http://dx.doi.org/10.1159/000088478] [PMID: 16301830]
[http://dx.doi.org/10.1210/mend-5-12-1806] [PMID: 1791831]
[http://dx.doi.org/10.1210/er.2003-0027] [PMID: 15294883]
[http://dx.doi.org/10.1016/S0021-9258(18)35712-0] [PMID: 1464614]
[http://dx.doi.org/10.1161/CIRCRESAHA.116.302953] [PMID: 25953926]
[http://dx.doi.org/10.1152/ajpheart.00330.2002] [PMID: 12388327]
[http://dx.doi.org/10.1093/emboj/20.11.2768] [PMID: 11387210]
[http://dx.doi.org/10.1161/01.RES.84.12.1416] [PMID: 10381894]
[PMID: 10362674]
[http://dx.doi.org/10.1038/377239a0] [PMID: 7545787]
[http://dx.doi.org/10.1111/j.1523-1755.2005.00575.x] [PMID: 16164642]
[http://dx.doi.org/10.1093/cvr/cvn007] [PMID: 18192240]
[http://dx.doi.org/10.1074/jbc.M700078200] [PMID: 17339326]
[http://dx.doi.org/10.1172/JCI66056] [PMID: 23160196]
[http://dx.doi.org/10.1038/nm0202-128] [PMID: 11821896]
[http://dx.doi.org/10.1177/1947601911423654] [PMID: 22866203]
[http://dx.doi.org/10.1161/01.RES.86.3.319] [PMID: 10679484]
[http://dx.doi.org/10.1073/pnas.92.12.5510] [PMID: 7539918]
[http://dx.doi.org/10.1124/mol.106.027029] [PMID: 16887934]
[http://dx.doi.org/10.4161/cc.6.6.3981] [PMID: 17361105]
[http://dx.doi.org/10.1016/0304-3835(95)03915-J] [PMID: 7553606]
[http://dx.doi.org/10.3390/cancers13071685] [PMID: 33918490]
[http://dx.doi.org/10.1016/j.ejmech.2017.08.044] [PMID: 29157685]
[http://dx.doi.org/10.1016/j.ejmech.2019.111664]
[http://dx.doi.org/10.3390/cancers7030860] [PMID: 26404379]
[http://dx.doi.org/10.1038/s41388-021-01863-w] [PMID: 34145400]
[http://dx.doi.org/10.1016/S1359-6101(01)00029-6] [PMID: 11750879]
[http://dx.doi.org/10.1158/1078-0432.CCR-03-0564] [PMID: 14977817]
[http://dx.doi.org/10.1016/S0960-894X(01)00344-4] [PMID: 11459659]
[http://dx.doi.org/10.1200/JCO.2003.10.038] [PMID: 12748244]
[http://dx.doi.org/10.1038/sj.bjc.6602793] [PMID: 16189524]
[http://dx.doi.org/10.1038/sj.bjc.6600182] [PMID: 11953865]
[PMID: 10815932]
[http://dx.doi.org/10.1001/jama.290.16.2149] [PMID: 14570950]
[http://dx.doi.org/10.1200/JCO.2005.05.153] [PMID: 15699477]
[PMID: 15114701]
[http://dx.doi.org/10.1016/S0140-6736(05)67625-8] [PMID: 16257339]
[http://dx.doi.org/10.1097/01243894-200610000-00014] [PMID: 17409969]
[http://dx.doi.org/10.1200/JCO.2006.06.3958] [PMID: 17075123]
[http://dx.doi.org/10.1002/cncr.23282] [PMID: 18219661]
[http://dx.doi.org/10.1074/jbc.M207135200] [PMID: 12196540]
[http://dx.doi.org/10.1016/j.phrs.2015.10.021] [PMID: 26529477]
[http://dx.doi.org/10.1042/BJ20121513] [PMID: 23101586]
[http://dx.doi.org/10.1200/JCO.2011.40.1315] [PMID: 22547605]
[http://dx.doi.org/10.1016/S0140-6736(11)60545-X] [PMID: 21621716]
[http://dx.doi.org/10.1001/jamaoncol.2019.1847] [PMID: 31393548]
[http://dx.doi.org/10.1016/j.chembiol.2004.02.029] [PMID: 15157880]
[http://dx.doi.org/10.1371/journal.pmed.0020073] [PMID: 15737014]
[PMID: 9354447]
[http://dx.doi.org/10.1158/1078-0432.CCR-06-2923] [PMID: 17545550]
[http://dx.doi.org/10.1158/1535-7163.MCT-08-0354] [PMID: 18566242]
[http://dx.doi.org/10.1158/1535-7163.MCT-06-0166] [PMID: 17121914]
[http://dx.doi.org/10.1097/01.cad.0000127664.66472.60] [PMID: 15166626]
[PMID: 31720077]
[http://dx.doi.org/10.1093/jnci/djn216] [PMID: 18664652]
[http://dx.doi.org/10.1158/0008-5472.CAN-05-1182] [PMID: 16452222]
[http://dx.doi.org/10.1158/1535-7163.MCT-08-0168] [PMID: 18644997]
[PMID: 12467226]
[http://dx.doi.org/10.1200/JCO.2008.21.4437] [PMID: 20124187]
[http://dx.doi.org/10.1093/annonc/mdm601] [PMID: 18283035]
[http://dx.doi.org/10.1200/JCO.2013.52.1161] [PMID: 24711549]
[http://dx.doi.org/10.1200/JCO.2007.14.0590] [PMID: 18458039]
[http://dx.doi.org/10.1200/JCO.2007.13.9949] [PMID: 18212337]
[http://dx.doi.org/10.1038/sj.bjc.6605343] [PMID: 19844234]
[http://dx.doi.org/10.1093/annonc/mdn759] [PMID: 19179558]
[http://dx.doi.org/10.1056/NEJMoa064320] [PMID: 17192538]
[PMID: 19707428]
[http://dx.doi.org/10.1200/JCO.2014.57.1794] [PMID: 25605838]
[http://dx.doi.org/10.1200/JCO.2011.40.5241] [PMID: 23509322]
[http://dx.doi.org/10.1016/S1470-2045(12)70508-9] [PMID: 23234763]
[http://dx.doi.org/10.1007/s40265-013-0111-6] [PMID: 23982599]
[http://dx.doi.org/10.1038/onc.2008.109] [PMID: 18408761]
[http://dx.doi.org/10.1200/JCO.2013.49.8782] [PMID: 23980079]
[http://dx.doi.org/10.1200/JCO.2012.44.2806] [PMID: 23816960]
[http://dx.doi.org/10.1016/S1470-2045(13)70604-1] [PMID: 24439929]
[http://dx.doi.org/10.1016/S1470-2045(14)71173-8] [PMID: 25589191]
[http://dx.doi.org/10.1158/1535-7163.MCT-19-0873] [PMID: 32241871]
[PMID: 16736981]
[http://dx.doi.org/10.1158/0008-5472.SABCS-09-5104]
[http://dx.doi.org/10.1016/j.phrs.2019.03.006] [PMID: 30877063]
[http://dx.doi.org/10.1016/j.str.2012.11.014] [PMID: 23273428]
[http://dx.doi.org/10.1158/0008-5472.CAN-07-1885] [PMID: 18089823]
[http://dx.doi.org/10.1158/1535-7163.MCT-11-0730] [PMID: 22761403]
[http://dx.doi.org/10.1016/S1470-2045(17)30608-3] [PMID: 28958502]
[http://dx.doi.org/10.1517/14728222.2011.648617] [PMID: 22239438]
[http://dx.doi.org/10.1016/j.bioorg.2020.103811] [PMID: 32278207]
[http://dx.doi.org/10.1021/jm990482t] [PMID: 10753475]
[http://dx.doi.org/10.1074/jbc.M008786200] [PMID: 11278435]
[http://dx.doi.org/10.1016/S0093-7754(01)90285-4] [PMID: 11706399]
[http://dx.doi.org/10.1093/emboj/21.10.2407] [PMID: 12006493]
[http://dx.doi.org/10.1002/pbc.20454] [PMID: 16007579]
[http://dx.doi.org/10.3892/or.17.4.887] [PMID: 17342332]
[http://dx.doi.org/10.1016/j.clbc.2011.07.001] [PMID: 21903480]
[http://dx.doi.org/10.1371/journal.pone.0021487] [PMID: 21789172]
[http://dx.doi.org/10.1200/JCO.2016.34.15_suppl.e15598]
[http://dx.doi.org/10.1200/JCO.2020.38.15_suppl.4597]
[http://dx.doi.org/10.1038/s41598-017-18702-2] [PMID: 29321587]
[http://dx.doi.org/10.1111/cas.12449] [PMID: 24837299]
[http://dx.doi.org/10.1186/s13058-019-1178-0] [PMID: 31892325]
[http://dx.doi.org/10.1016/j.canlet.2011.01.010] [PMID: 21306821]
[http://dx.doi.org/10.1021/acs.jmedchem.1c02080] [PMID: 35486541]
[http://dx.doi.org/10.1002/ijc.26276] [PMID: 21732342]
[http://dx.doi.org/10.1056/NEJMoa1411817] [PMID: 25923549]
[http://dx.doi.org/10.1158/2159-8290.CD-14-0337] [PMID: 24893891]
[http://dx.doi.org/10.1021/jm500973a] [PMID: 25271963]
[http://dx.doi.org/10.1021/acs.jmedchem.0c00891] [PMID: 32672461]
[http://dx.doi.org/10.1016/j.jsb.2015.10.018] [PMID: 26522274]
[http://dx.doi.org/10.1038/nm.3854] [PMID: 25939061]
[PMID: 26885448]
[http://dx.doi.org/10.1056/NEJMoa1713137] [PMID: 29151359]
[http://dx.doi.org/10.1016/S1470-2045(11)70393-X] [PMID: 22285168]
[http://dx.doi.org/10.1016/S1470-2045(16)30033-X] [PMID: 27083334]
[http://dx.doi.org/10.1056/NEJMoa0810699] [PMID: 19692680]
[http://dx.doi.org/10.1158/2159-8290.CD-20-1683] [PMID: 33632773]
[http://dx.doi.org/10.1158/0008-5472.CAN-21-1526] [PMID: 34380634]
[http://dx.doi.org/10.1021/ml300327z] [PMID: 24900643]
[http://dx.doi.org/10.1158/0008-5472.CAN-03-2868] [PMID: 15173008]
[http://dx.doi.org/10.1158/2159-8290.CD-18-0903] [PMID: 31092401]
[http://dx.doi.org/10.1038/s41591-018-0007-9] [PMID: 29686424]
[http://dx.doi.org/10.1038/79534] [PMID: 10973323]
[http://dx.doi.org/10.1158/1535-7163.21.3.1] [PMID: 14749472]
[http://dx.doi.org/10.1172/JCI25167] [PMID: 16453019]
[http://dx.doi.org/10.1200/JCO.2005.01.8960] [PMID: 16710023]
[http://dx.doi.org/10.1007/s40265-018-0997-0] [PMID: 30341682]
[http://dx.doi.org/10.1016/S1470-2045(20)30702-6] [PMID: 33581774]
[http://dx.doi.org/10.3389/fonc.2020.00811] [PMID: 32528890]
[http://dx.doi.org/10.1016/j.ejps.2017.01.021] [PMID: 28115222]
[http://dx.doi.org/10.1158/2159-8290.CD-13-0314] [PMID: 24065731]
[http://dx.doi.org/10.1056/NEJMoa1413654] [PMID: 25923550]
[http://dx.doi.org/10.18632/oncotarget.18588] [PMID: 28881827]
[http://dx.doi.org/10.1016/j.jtocrr.2020.100114] [PMID: 34589984]
[http://dx.doi.org/10.1038/nature17960] [PMID: 27251290]
[http://dx.doi.org/10.1186/s13045-016-0290-1] [PMID: 27448564]
[http://dx.doi.org/10.1007/s43440-020-00131-0] [PMID: 32666476]
[http://dx.doi.org/10.1021/acsomega.8b03256]
[http://dx.doi.org/10.1158/0008-5472.CAN-03-3681] [PMID: 15256466]
[http://dx.doi.org/10.1158/1078-0432.CCR-04-1665] [PMID: 15756022]
[http://dx.doi.org/10.1158/0008-5472.CAN-04-3700] [PMID: 15867367]
[http://dx.doi.org/10.1593/tlo.10163] [PMID: 20885895]
[http://dx.doi.org/10.1158/1078-0432.CCR-06-1751] [PMID: 17317822]
[http://dx.doi.org/10.1007/s00280-012-1854-6] [PMID: 22392572]
[http://dx.doi.org/10.1158/1078-0432.CCR-06-0642] [PMID: 17062696]
[http://dx.doi.org/10.3390/cancers12092502] [PMID: 32899268]
[http://dx.doi.org/10.1007/s10637-010-9389-3] [PMID: 20119866]
[http://dx.doi.org/10.1158/1535-7163.MCT-08-0493] [PMID: 18765823]
[http://dx.doi.org/10.1021/jm2008634] [PMID: 22003817]
[http://dx.doi.org/10.1074/jbc.M110.206193] [PMID: 21454582]
[http://dx.doi.org/10.1016/j.brainresbull.2012.01.002] [PMID: 22245027]
[http://dx.doi.org/10.1038/bjc.2011.590] [PMID: 22240796]
[http://dx.doi.org/10.1158/1078-0432.CCR-09-2353] [PMID: 20145185]
[http://dx.doi.org/10.1186/s12885-016-3039-x] [PMID: 28086832]
[PMID: 20688607]
[PMID: 10389946]
[http://dx.doi.org/10.1021/acs.jctc.7b01170] [PMID: 29474075]
[http://dx.doi.org/10.1182/blood-2007-09-115030] [PMID: 18094329]
[PMID: 9796979]
[PMID: 9626456]
[http://dx.doi.org/10.1007/s40265-016-0606-z] [PMID: 27357069]
[http://dx.doi.org/10.1016/j.phrs.2018.11.014] [PMID: 30500458]
[http://dx.doi.org/10.1039/C7RA04261B]
[http://dx.doi.org/10.1186/s13045-016-0268-z] [PMID: 27071706]
[http://dx.doi.org/10.1158/0008-5472.CAN-18-1281] [PMID: 30718357]
[http://dx.doi.org/10.1177/1758835920940948] [PMID: 32754231]
[http://dx.doi.org/10.1371/journal.pone.0231877] [PMID: 32315352]
[http://dx.doi.org/10.1093/annonc/mdz343.034]
[http://dx.doi.org/10.1038/s42004-022-00718-z] [PMID: 36698015]
[http://dx.doi.org/10.1016/S1470-2045(20)30109-1] [PMID: 32203698]
[http://dx.doi.org/10.2217/fon-2020-0429] [PMID: 32677452]
[http://dx.doi.org/10.1007/s40265-020-01330-y] [PMID: 32472305]
[http://dx.doi.org/10.1016/j.phrs.2019.104567] [PMID: 31770593]
[http://dx.doi.org/10.1172/jci.insight.154824] [PMID: 35393953]
[http://dx.doi.org/10.1158/1535-7163.MCT-16-0589] [PMID: 28341788]
[http://dx.doi.org/10.1200/JCO.2014.60.7341] [PMID: 26324363]
[http://dx.doi.org/10.18632/oncotarget.8132] [PMID: 26992226]
[http://dx.doi.org/10.1016/j.phrs.2021.105463] [PMID: 33513356]
[http://dx.doi.org/10.1186/s12885-015-2000-8] [PMID: 26675289]
[http://dx.doi.org/10.1158/1538-7445.AM2014-1738]
[http://dx.doi.org/10.1080/13543784.2021.1864320] [PMID: 33307867]
[http://dx.doi.org/10.1158/2159-8290.CD-12-0210] [PMID: 23002168]
[http://dx.doi.org/10.1093/emboj/17.20.5896] [PMID: 9774334]
[http://dx.doi.org/10.1002/hep.30481] [PMID: 30575985]
[http://dx.doi.org/10.1021/jm2006222] [PMID: 21936542]
[http://dx.doi.org/10.1158/1535-7163.MCT-14-0248] [PMID: 25169980]
[http://dx.doi.org/10.1158/1078-0432.CCR-18-1959] [PMID: 30745300]
[http://dx.doi.org/10.1002/ijc.32224] [PMID: 30807645]
[http://dx.doi.org/10.1016/S1470-2045(19)30412-7] [PMID: 31405822]
[http://dx.doi.org/10.1200/JCO.2020.38.6_suppl.527]
[http://dx.doi.org/10.1200/JCO.21.02303] [PMID: 36240478]
[http://dx.doi.org/10.1200/JCO.2020.38.15_suppl.5014]
[http://dx.doi.org/10.1038/oncsis.2016.48] [PMID: 27429073]
[http://dx.doi.org/10.1158/1535-7163.TARG-13-A270]
[http://dx.doi.org/10.1158/1538-7445.AM2019-CT238]
[http://dx.doi.org/10.1002/cmdc.201800719] [PMID: 30600916]
[http://dx.doi.org/10.1158/0008-5472.CAN-19-2568] [PMID: 32973082]
[http://dx.doi.org/10.1158/2159-8290.CD-19-0182] [PMID: 31109923]
[http://dx.doi.org/10.1023/A:1006367032156] [PMID: 10638483]
[http://dx.doi.org/10.1182/blood-2003-10-3650] [PMID: 14715624]
[http://dx.doi.org/10.1158/0008-5472.CAN-09-1576] [PMID: 19903855]
[http://dx.doi.org/10.1046/j.1471-4159.2000.0751520.x] [PMID: 10987832]
[http://dx.doi.org/10.1002/jnr.10773] [PMID: 14598292]
[http://dx.doi.org/10.1158/1535-7163.MCT-11-0306] [PMID: 21900693]
[http://dx.doi.org/10.1007/s11523-017-0502-9] [PMID: 28589492]
[http://dx.doi.org/10.1371/journal.pone.0162594] [PMID: 27627808]
[http://dx.doi.org/10.1200/JCO.2020.38.6_suppl.TPS590]
[http://dx.doi.org/10.1158/0008-5472.CAN-13-3723] [PMID: 25082815]
[http://dx.doi.org/10.1158/2159-8290.CD-17-0146] [PMID: 28450426]
[http://dx.doi.org/10.1158/1538-7445.AM2011-3568]
[http://dx.doi.org/10.1038/s41467-022-30666-0] [PMID: 35688802]
[http://dx.doi.org/10.1158/1078-0432.CCR-13-0190] [PMID: 23658459]
[http://dx.doi.org/10.1158/1078-0432.CCR-12-2885] [PMID: 23339124]
[http://dx.doi.org/10.1158/1078-0432.CCR-13-3006] [PMID: 24691021]
[http://dx.doi.org/10.1038/ncomms8877] [PMID: 26203596]
[http://dx.doi.org/10.1182/blood-2004-10-3913] [PMID: 15598814]
[http://dx.doi.org/10.1016/j.jhep.2011.09.017] [PMID: 22027573]
[http://dx.doi.org/10.1158/1078-0432.CCR-04-2129] [PMID: 15897558]
[PMID: 21115896]
[http://dx.doi.org/10.1021/jm051106d] [PMID: 16570908]
[http://dx.doi.org/10.1371/journal.pone.0142355] [PMID: 26528545]
[http://dx.doi.org/10.1158/1078-0432.CCR-08-0509] [PMID: 18829493]
[PMID: 10945623]
[http://dx.doi.org/10.1158/1078-0432.CCR-0828-03] [PMID: 14760097]
[http://dx.doi.org/10.1007/s00270-010-0081-y] [PMID: 21184227]
[http://dx.doi.org/10.1016/S2468-1253(17)30290-X] [PMID: 28988687]
[http://dx.doi.org/10.1158/1535-7163.MCT-10-0574] [PMID: 21177375]
[http://dx.doi.org/10.1111/j.1365-2141.2010.08248.x] [PMID: 20560971]
[http://dx.doi.org/10.1186/s13058-018-1014-y] [PMID: 30071865]
[http://dx.doi.org/10.1186/1478-811X-11-97] [PMID: 24359404]
[http://dx.doi.org/10.1016/j.ccell.2019.04.006] [PMID: 31085175]
[http://dx.doi.org/10.1177/17562848211008177] [PMID: 33948116]
[http://dx.doi.org/10.1200/JCO.21.00217] [PMID: 34343033]
[http://dx.doi.org/10.3389/fonc.2022.927587] [PMID: 36119525]
[http://dx.doi.org/10.1158/1538-7445.AM2015-791]
[http://dx.doi.org/10.2147/OTT.S68773]
[http://dx.doi.org/10.1158/1078-0432.CCR-12-0625] [PMID: 22745105]
[http://dx.doi.org/10.1182/blood.V124.21.389.389]
[http://dx.doi.org/10.1007/s00280-010-1526-3] [PMID: 21116624]
[http://dx.doi.org/10.1016/j.mam.2017.11.007] [PMID: 29137923]
[http://dx.doi.org/10.1080/10245330701384179] [PMID: 17852433]
[http://dx.doi.org/10.1016/j.jphs.2015.10.008] [PMID: 26644081]
[http://dx.doi.org/10.1186/1472-6807-9-7] [PMID: 19236722]
[http://dx.doi.org/10.1182/blood-2005-05-1932] [PMID: 16030188]
[http://dx.doi.org/10.1053/j.seminoncol.2011.01.016] [PMID: 21419934]
[http://dx.doi.org/10.1016/j.ccr.2005.01.007] [PMID: 15710326]
[http://dx.doi.org/10.1016/j.leukres.2006.04.005] [PMID: 16797704]
[http://dx.doi.org/10.1158/0008-5472.CAN-09-2541] [PMID: 20145145]
[http://dx.doi.org/10.1200/jco.2008.26.15_suppl.14657]
[http://dx.doi.org/10.1074/jbc.M110.204404] [PMID: 21247903]
[http://dx.doi.org/10.3389/fchem.2022.860985] [PMID: 35494629]
[http://dx.doi.org/10.3390/cancers12061366] [PMID: 32466597]
[http://dx.doi.org/10.1016/S1470-2045(21)00660-4] [PMID: 35030333]
[http://dx.doi.org/10.1186/1479-5876-6-53] [PMID: 18823558]
[http://dx.doi.org/10.1038/nbt1328] [PMID: 17721511]
[http://dx.doi.org/10.1001/jamaoncol.2018.0601] [PMID: 29710216]
[http://dx.doi.org/10.5581/1516-8484.20110034] [PMID: 23284261]
[http://dx.doi.org/10.1111/cas.12320] [PMID: 24205792]
[http://dx.doi.org/10.1016/j.drup.2014.11.002] [PMID: 25554624]
[http://dx.doi.org/10.1016/j.bcp.2014.02.012] [PMID: 24565910]
[http://dx.doi.org/10.1016/j.jash.2018.03.008] [PMID: 29703600]
[http://dx.doi.org/10.1038/nrd1955] [PMID: 16518379]
[http://dx.doi.org/10.4103/0301-4738.36476] [PMID: 17951898]
[http://dx.doi.org/10.1056/NEJMoa042760] [PMID: 15625332]
[PMID: 16828500]
[http://dx.doi.org/10.1021/mp500160v] [PMID: 25162961]
[http://dx.doi.org/10.2147/DDDT.S109640] [PMID: 29033542]
[http://dx.doi.org/10.1016/j.bulcan.2017.03.013] [PMID: 28477875]
[http://dx.doi.org/10.1016/j.phrs.2017.03.010] [PMID: 28330784]
[http://dx.doi.org/10.1158/0008-5472.CAN-10-2527] [PMID: 21613405]
[http://dx.doi.org/10.1634/theoncologist.11-7-753] [PMID: 16880234]
[http://dx.doi.org/10.1158/1078-0432.CCR-04-0157] [PMID: 15355900]
[PMID: 12738717]
[PMID: 21523318]
[http://dx.doi.org/10.1007/s00011-011-0431-5] [PMID: 22245957]
[http://dx.doi.org/10.1016/S1470-2045(12)70270-X] [PMID: 22805291]
[http://dx.doi.org/10.1021/jm201330u] [PMID: 22320343]
[http://dx.doi.org/10.1074/jbc.M705774200] [PMID: 18055465]
[http://dx.doi.org/10.1007/s10637-011-9699-0] [PMID: 21655918]
[http://dx.doi.org/10.3390/diseases3040306] [PMID: 28943627]
[http://dx.doi.org/10.1002/ptr.5551] [PMID: 26744260]
[http://dx.doi.org/10.3389/fphar.2020.564833] [PMID: 33390942]
[http://dx.doi.org/10.1007/s40265-020-01347-3] [PMID: 32557339]
[http://dx.doi.org/10.1186/s13104-019-4163-x] [PMID: 30871613]
[http://dx.doi.org/10.1158/1535-7163.MCT-09-0477] [PMID: 19934279]
[http://dx.doi.org/10.1021/jm2007613] [PMID: 21812414]
[http://dx.doi.org/10.3390/cancers10090280] [PMID: 30134579]
[http://dx.doi.org/10.1016/j.bmcl.2015.02.002] [PMID: 25736998]
[http://dx.doi.org/10.1517/14728222.2012.680957] [PMID: 22530990]
[http://dx.doi.org/10.1186/s12943-018-0795-z] [PMID: 29455657]
[http://dx.doi.org/10.1016/j.phymed.2016.12.002] [PMID: 28190465]
[http://dx.doi.org/10.1006/bbrc.1998.8452] [PMID: 9571170]
[http://dx.doi.org/10.1371/journal.pone.0065113] [PMID: 23762292]
[http://dx.doi.org/10.1080/17425247.2021.1825377] [PMID: 32954834]
[http://dx.doi.org/10.1110/ps.052045306] [PMID: 16597832]
[http://dx.doi.org/10.2165/11595310-000000000-00000] [PMID: 21770481]
[http://dx.doi.org/10.1186/s13045-019-0731-8] [PMID: 31023335]
[http://dx.doi.org/10.1158/1078-0432.CCR-12-2353] [PMID: 23231950]
[http://dx.doi.org/10.1074/jbc.M605604200] [PMID: 16928683]
[http://dx.doi.org/10.3390/cells8040316] [PMID: 30959819]
[http://dx.doi.org/10.3390/molecules26216677] [PMID: 34771085]
[PMID: 12183421]
[http://dx.doi.org/10.1016/j.bcp.2012.04.010] [PMID: 22548830]
[http://dx.doi.org/10.1016/j.urolonc.2012.03.003] [PMID: 22608542]
[http://dx.doi.org/10.1158/1078-0432.CCR-11-2041] [PMID: 22611027]
[PMID: 12684431]
[http://dx.doi.org/10.2146/ajhp120253] [PMID: 23640345]
[http://dx.doi.org/10.2147/CMAR.S188316] [PMID: 31118801]
[http://dx.doi.org/10.1186/1471-2407-11-309] [PMID: 21781317]
[http://dx.doi.org/10.1158/1078-0432.CCR-07-5270] [PMID: 18765537]
[http://dx.doi.org/10.1038/bjc.2013.374] [PMID: 23860537]
[http://dx.doi.org/10.1021/ml500394m] [PMID: 25589937]
[http://dx.doi.org/10.21873/anticanres.13802] [PMID: 31704822]
[http://dx.doi.org/10.1002/onco.13566] [PMID: 33044793]
[http://dx.doi.org/10.1002/ijc.23131] [PMID: 17943726]
[http://dx.doi.org/10.1021/jm501562a] [PMID: 25474320]
[http://dx.doi.org/10.1183/09031936.00174914] [PMID: 25745043]
[http://dx.doi.org/10.1158/0008-5472.CAN-07-6307] [PMID: 18559524]
[http://dx.doi.org/10.1016/S1470-2045(13)70586-2] [PMID: 24411639]
[http://dx.doi.org/10.1074/jbc.RA119.007682] [PMID: 31118272]
[http://dx.doi.org/10.1124/jpet.113.208223] [PMID: 24556663]
[http://dx.doi.org/10.1080/17476348.2016.1249854] [PMID: 27744713]
[http://dx.doi.org/10.1183/13993003.02106-2017] [PMID: 29794129]
[http://dx.doi.org/10.1021/jm800566m] [PMID: 18620382]
[http://dx.doi.org/10.3816/CBC.2003.n.007] [PMID: 12636887]
[http://dx.doi.org/10.1073/pnas.1207759109] [PMID: 22988103]
[http://dx.doi.org/10.1002/jor.22091] [PMID: 22359392]
[http://dx.doi.org/10.1097/IAE.0b013e318240a558] [PMID: 22466477]
[http://dx.doi.org/10.1016/j.ejca.2012.12.010] [PMID: 23321547]
[http://dx.doi.org/10.1200/JCO.2008.21.6994] [PMID: 20008644]
[http://dx.doi.org/10.1038/nrd3073] [PMID: 20043026]
[http://dx.doi.org/10.1177/1756287215614236] [PMID: 26834841]
[http://dx.doi.org/10.1186/s13045-018-0624-2] [PMID: 29925402]
[http://dx.doi.org/10.1111/j.1747-0285.2010.01054.x] [PMID: 21118377]
[http://dx.doi.org/10.1016/j.ccr.2009.09.028] [PMID: 19878872]
[http://dx.doi.org/10.1158/1535-7163.MCT-10-1044] [PMID: 21482694]
[http://dx.doi.org/10.1016/S2352-3026(15)00127-1] [PMID: 26436130]
[http://dx.doi.org/10.1056/NEJMoa1306494] [PMID: 24180494]
[http://dx.doi.org/10.3324/haematol.2015.132845] [PMID: 26341741]
[http://dx.doi.org/10.1016/S1470-2045(16)00080-2] [PMID: 27083332]
[http://dx.doi.org/10.1093/oncolo/oyab040] [PMID: 35641211]
[http://dx.doi.org/10.1016/j.tvjl.2021.105621] [PMID: 33593493]
[http://dx.doi.org/10.1177/1947601912462126] [PMID: 23226582]
[http://dx.doi.org/10.1182/blood.2021012082] [PMID: 34407543]
[http://dx.doi.org/10.1038/nrclinonc.2017.100] [PMID: 28719584]
[http://dx.doi.org/10.1002/ijc.25864] [PMID: 21170960]
[http://dx.doi.org/10.1002/jcp.24148] [PMID: 22777740]
[http://dx.doi.org/10.1056/NEJMoa0708857] [PMID: 18650514]
[http://dx.doi.org/10.1016/S0140-6736(16)32453-9] [PMID: 27932229]
[http://dx.doi.org/10.1002/ijc.28669] [PMID: 24347491]
[http://dx.doi.org/10.1634/theoncologist.2013-0059] [PMID: 24821824]
[http://dx.doi.org/10.1111/hepr.13181] [PMID: 29689631]
[http://dx.doi.org/10.1007/s00223-013-9795-6] [PMID: 24068282]
[http://dx.doi.org/10.1111/j.1365-2141.2004.04814.x] [PMID: 14871245]
[PMID: 9892193]
[http://dx.doi.org/10.1002/path.4575] [PMID: 26096068]
[http://dx.doi.org/10.1093/jb/mvab053] [PMID: 33944931]
[http://dx.doi.org/10.1371/journal.pone.0256755] [PMID: 34473785]
[http://dx.doi.org/10.1021/ja902010p] [PMID: 19572644]
[http://dx.doi.org/10.3390/cells11040634] [PMID: 35203285]
[http://dx.doi.org/10.1038/aps.2017.5] [PMID: 28344323]
[http://dx.doi.org/10.1200/JCO.2021.39.3_suppl.327]
[http://dx.doi.org/10.1038/sj.bjc.6603813] [PMID: 17519900]
[http://dx.doi.org/10.1158/0008-5472.CAN-05-4290] [PMID: 16982756]
[http://dx.doi.org/10.1177/1758835920923818] [PMID: 32547647]
[PMID: 23788831]
[http://dx.doi.org/10.2217/fon-2020-0443] [PMID: 32692256]
[http://dx.doi.org/10.2147/OTT.S101385] [PMID: 28008275]
[http://dx.doi.org/10.1038/nrc2559] [PMID: 19104514]
[http://dx.doi.org/10.3390/ijms19092599] [PMID: 30200486]
[http://dx.doi.org/10.1038/nrd2380] [PMID: 17690708]
[http://dx.doi.org/10.1007/s11060-010-0259-9] [PMID: 20524040]
[PMID: 12538485]
[http://dx.doi.org/10.1200/JCO.2008.20.9890] [PMID: 19451429]
[http://dx.doi.org/10.1177/1756287217713902] [PMID: 29662544]
[http://dx.doi.org/10.1093/annonc/mdv149] [PMID: 25802238]
[http://dx.doi.org/10.2478/jvetres-2021-042] [PMID: 34917849]
[http://dx.doi.org/10.1212/NXI.0000000000001148] [PMID: 35190477]