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ISSN (Print): 2210-299X
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Short Communication

The Pharmacological Significance of Convolvulus Prostratus: Modern Perspectives of An Ancient Herb

Author(s): Jeetendra Kumar Gupta, Jyoti Verma, Girdhar Khandelwal, Krishanveer Singh and Kuldeep Singh*

Volume 1, 2023

Published on: 07 November, 2023

Article ID: e2210299X264928 Pages: 6

DOI: 10.2174/012210299X264928231020123247

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Abstract

Convolvulus Prostratus, also known as sankhapushpi, is a very adaptable plant frequently used as a nervine tonic, nootropic, and rejuvenator in cases of insanity and epilepsy and has a broad spectrum of beneficial properties. Several medicinal qualities, including anxiety, neuroprotective, antioxidant, analgesic, immunomodulatory, antibacterial, antidiabetic, and cardioprotective effects, have been related to this herb in ancient literature. Numerous bioactive phytoconstituents, including kaempferol(flavonoid), ceryl alcohol, scopolamine(phenolics), and convolamine (alkaloid), are associated with the therapeutic capabilities of this herb. The Whole herb or its juice is credited with alterative, antiphlogistic, and nervine tonic action. Additionally, the involvement of C. prostratus extracts in neurodegenerative was thoroughly established. Although this significant herb has comprehensive preclinical studies, thorough clinical research and mechanistic mode-of-action studies still need to be conducted. With a detailed analysis of the research gaps, the current review aims to highlight the phytonutrient constituents, beneficial characteristics, and therapeutic properties of C. prostratus. The creation of CNS phytopharmaceuticals, derived from C. prostratus, is hoped to flourish due to the scientific upgrade on the ethnomedicinal characteristics of this herb.

[1]
Fatima, A.; Agrawal, P.; Singh, P.P. Herbal option for diabetes: An overview. Asian Pac. J. Trop. Dis., 2012, 2(1), S536-S544.
[http://dx.doi.org/10.1016/S2222-1808(12)60216-3]
[2]
Agarwal, P.; Alok, S.; Fatima, A.; Singh, P.P. Herbal remedies for neurodegenerative disorder (alzheimer’s disease): A review. Int. J. Pharm. Sci. Res., 2013, 4(4), 3328-3340.
[3]
Agarwa, P.; Sharma, B.; Fatima, A.; Jain, S.K. An update on Ayurvedic herb Convolvulus pluricaulis Choisy. Asian Pac. J. Trop. Biomed., 2014, 4(3), 245-252.
[http://dx.doi.org/10.1016/S2221-1691(14)60240-9] [PMID: 25182446]
[4]
Thakur, S.; Kaurav, H. Ayurvedic Medicinal Importance of Shankhpushpi (Convolvulus Pluricaulis): Potentail Cognition Boosting Herb. Int. J. Pharma. Sci. Health Care, 2021, 4(10), 2249-5738.
[5]
Amin, H.; Sharma, R.; Vyas, M.; Prajapati, P.K.; Dhiman, K. Shankhapushpi (Convolvulus pluricaulis Choisy): Validation of the Ayurvedic therapeutic claims through contemporary studies. International Journal of Green Pharmacy., 2014, 8(4), 193-200.
[http://dx.doi.org/10.1016/j.ijpharm.2014.08.028]
[6]
Mishra, S.H.; Sethiya, N.K. Review on ethnomedicinal uses and phytopharmacology of memory boosting herb’ Convolvulus pluricaulis’ Choisy. Aust. J. Med. Herb., 2010, 22(1), 19-25.
[7]
Bhalerao, S.A.; Verma, D.R.; Teli, N.C.; Trikannad, A.A. Ethnobotany, phytochemistry and pharmacology of Convolvulus pluricaulis. Choisy. Res. J. Pharm. Biol. Chem. Sci., 2014, 5, 629-636.
[8]
Balkrishna, A.; Thakur, P.; Varshney, A. Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus – A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies. Front. Pharmacol., 2020, 11(3), 171.
[http://dx.doi.org/10.3389/fphar.2020.00171]
[9]
Pan, R.; Dai, Y.; Gao, X.; Xia, Y. Scopolin isolated from Erycibe obtusifolia Benth stems suppresses adjuvant-induced rat arthritis by inhibiting inflammation and angiogenesis. Int. Immunopharmacol., 2009, 9(7-8), 859-869.
[http://dx.doi.org/10.1016/j.intimp.2009.02.019] [PMID: 19327410]
[10]
Malik, S.; Ahmad, S.; Sadiq, A.; Alam, K.; Wariss, H.M.; Ahmad, I.; Hayat, M.Q.; Anjum, S.; Mukhtar, M. A comparative ethno-botanical study of Cholistan (an arid area) and Pothwar (a semi-arid area) of Pakistan for traditional medicines. J. Ethnobiol. Ethnomed., 2015, 11(1), 31.
[http://dx.doi.org/10.1186/s13002-015-0018-2] [PMID: 25925727]
[11]
Rizwan, M.; Khan, A.A. Assessment of efficacy of Sankhahuli (Convolvulus pluricaulis Chois.) and gokhru (Tribulus terrestris L.) in the management of hypertension. Indian J. Tradit. Knowl., 2014, 13(2), 313-318.
[12]
Adams, M.; Gmünder, F.; Hamburger, M. Plants traditionally used in age related brain disorders—A survey of ethnobotanical literature. J. Ethnopharmacol., 2007, 113(3), 363-381.
[http://dx.doi.org/10.1016/j.jep.2007.07.016] [PMID: 17720341]
[13]
Aggarwal, B.B.; Prasad, S.; Reuter, S.; Kannappan, R.; Yadev, V.R.; Park, B.; Kim, J.H.; Gupta, S.C.; Phromnoi, K.; Sundaram, C.; Prasad, S.; Chaturvedi, M.M.; Sung, B. Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: “Reverse pharmacology” and “bedside to bench” approach. Curr. Drug Targets, 2011, 12(11), 1595-1653.
[http://dx.doi.org/10.2174/138945011798109464] [PMID: 21561421]
[14]
Dhingra, D.; Valecha, R. Screening for antidepressant-like activity of convolvulus pluricaulis choisy in mice. Pharmacologyonline, 2007, 1, 262-278.
[15]
Asthana, S.; Greig, N.H.; Holloway, H.W.; Raffaele, K.C.; Berardi, A.; Schapiro, M.B.; Rapoport, S.I.; Soncrant, T.T. Clinical pharmacokinetics of arecoline in subjects with Alzheimer’s disease. Clin. Pharmacol. Ther., 1996, 60(3), 276-282.
[http://dx.doi.org/10.1016/S0009-9236(96)90054-5] [PMID: 8841150]
[16]
Gapparov, A.M.; Razzakov, N.A.; Aripova, S.F. Alkaloids of Convolvulus subhirsutus from Uzbekistan. Chem. Nat. Compd., 2007, 43(3), 291-292.
[http://dx.doi.org/10.1007/s10600-007-0107-0]
[17]
Srivastava, D.N.; Deshpande, S.M. Gas chromatographic identification of fatty acids, fatty alcohols, and hydrocarbons of Convolvulus pluricaulis (chois). J. Am. Oil Chem. Soc., 1975, 52(8), 318-319.
[http://dx.doi.org/10.1007/BF02637735] [PMID: 1176757]
[18]
Patil, U.; Dixit, V. Densitometric standardization of herbal medical products containing Evolvulus alsinoides by quantification of a marker compound. J. Planar Chromatogr. Mod. TLC, 2005, 18(103), 234-239.
[http://dx.doi.org/10.1556/JPC.18.2005.3.13]
[19]
Park, C.; Moon, D.O.; Rhu, C.H.; Choi, B.T.; Lee, W.H.; Kim, G.Y.; Choi, Y.H. Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio Biol Pharm Bull . 2007 Jul;30(7):1317-23, 2007, 30(7), 1317-23.
[20]
Swain, S.S.; Rout, K.K.; Chand, P.K. Production of triterpenoid anti-cancer compound taraxerol in Agrobacterium-transformed root cultures of butterfly pea (Clitoria ternatea L.). Appl. Biochem. Biotechnol., 2012, 168(3), 487-503.
[http://dx.doi.org/10.1007/s12010-012-9791-8] [PMID: 22843061]
[21]
Xing, N.; Chen, Y.; Mitchell, S.H.; Young, C.Y.F. Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Carcinogenesis, 2001, 22(3), 409-414.
[http://dx.doi.org/10.1093/carcin/22.3.409] [PMID: 11238180]
[22]
Prats, E.; Bazzalo, M.; León, A.; Euphytica, J.J. Fungitoxic effect of scopolin and related coumarins on Sclerotinia sclerotiorum. A way to overcome sunflower head rot. Euphytica, 2006, 147, 451-460.
[23]
Nam, H.; Kim, M.M. Scopoletin has a potential activity for anti-aging via autophagy in human lung fibroblasts. Phytomedicine, 2015, 22(3), 362-368.
[http://dx.doi.org/10.1016/j.phymed.2015.01.004] [PMID: 25837273]
[24]
Dubey, S.K.; Singhvi, G.; Krishna, K.V.; Agnihotri, T.; Saha, R.N.; Gupta, G. Herbal medicines in neurodegenerative disorders: An evolutionary approach through novel drug delivery system. J Environ Pathol Toxicol Oncol., 2018, 37(3), 199-208.
[25]
Vinholes, J.; Silva, B.M.; Silva, L.R. Hydroxycinnamic acids (HCAS): Structure, biological properties and health effects. Adv. Med. Biol., 2015, 88(8), 1-33.
[26]
Patel, K.; Jain, A.; Patel, D.K. Medicinal significance, pharmacological activities, and analytical aspects of anthocyanidins ‘delphinidin’: A concise report. J. Acute Dis., 2013, 2(3), 169-178.
[http://dx.doi.org/10.1016/S2221-6189(13)60123-7]
[27]
Zingue, S.; Foyet, H.S.; Djiogue, S.; Ezo’o Ezo’o, Y.; Abaïssou, H.H.N.; Fachagbo, P.; Njamen, D. Effects of Ficus umbellata (Moraceae) Aqueous extract and 7-methoxycoumarin on scopolamine-induced spatial memory impairment in ovariectomized wistar rats. Behav. Neurol., 2018, 2018(10), 1-14.
[http://dx.doi.org/10.1155/2018/5751864] [PMID: 30363978]
[28]
Bihaqi, S.W.; Sharma, M.; Singh, A.P.; Tiwari, M. Neuroprotective role of Convolvulus pluricaulis on aluminium induced neurotoxicity in rat brain. J. Ethnopharmacol., 2009, 124(3), 409-415.
[http://dx.doi.org/10.1016/j.jep.2009.05.038] [PMID: 19505562]
[29]
Ahmad, I.; Swaroop, A.; Bagchi, D. A novel neuroprotective and antioxidative efficacy of a unique combination of standardized huperzia serrata, convolvulus pluricaulis and celastrus paniculatus extracts. J Nutr Health Sci., 2019, 6(2), 206.
[30]
Sethiya, N.K.; Nahata, A.; Singh, P.K.; Mishra, S.H. Neuropharmacological evaluation on four traditional herbs used as nervine tonic and commonly available as Shankhpushpi in India. J. Ayurveda Integr. Med., 2019, 10(1), 25-31.
[http://dx.doi.org/10.1016/j.jaim.2017.08.012] [PMID: 29530454]
[31]
Bihaqi, S.; Singh, A.; Tiwari, M. Supplementation of Convolvulus pluricaulis attenuates scopolamine-induced increased tau and Amyloid precursor protein (AβPP) expression in rat brain. Indian J. Pharmacol., 2012, 44(5), 593-598.
[http://dx.doi.org/10.4103/0253-7613.100383] [PMID: 23112420]
[32]
Sairam, K.; Rao, C.V.; Goel, R.K. Effect of Convolvulus pluricaulis Chois on gastric ulceration and secretion in rats. Indian J. Exp. Biol., 2001, 39(4), 350-354.
[PMID: 11491580]
[33]
Babu, Y.K.; Ganesh Mohanraj, K.; Priya, V.V. Effect of Convolvulus pluricaulis aqueous extract on behavioural changes and antioxidants in stress induced rats. Int. J. Res. Pharm. Sci., 2018, 9(2), 353-357.
[34]
Sristi, Verma; Reema, Sinha; Puspendra, Kumar; Faizal, Amin; Jainendra, Jain; Shivani, Tanwar Study of Convolvulus pluricaulis for antioxidant and anticonvulsant activity. Cent. Nerv. Syst. Agents Med. Chem., 2012, 12(1), 55-59.
[http://dx.doi.org/10.2174/187152412800229161] [PMID: 22280406]
[35]
Ratha, K.K.; Mishra, S.S. Anticonvulsant activity of Shankhapuspi (Convolvulus pluricaulis Chois) on Strychnine induced seizure in experimental animals. Int. J. Ayurv. Med.e, 2012, 3(2), 82-87.
[http://dx.doi.org/10.47552/ijam.v3i2.163]
[36]
Agarwal, P.; Sharma, B.; Alok, S. Screening of anti-inflammatory and anti-analgesic activity of Convolvulus pluricaulisitalic> Choisy. Int. J. Pharm. Sci. Res., 2014, 5(6), 2458.
[37]
Shrivastava, A.; Gupta, J.K.; Goyal, M.K. Flavonoids and antiepileptic drugs: A comprehensive review on their neuroprotective potentials. J. Med. P’ceutical Allied. Sci., 2022, 11(1), 4179-4186.
[38]
Shrivastava, A.; Gupta, J.K.; Goyal, M.K. Neuroprotective Efficacy of Quercetin with Lamotrigine and Gabapentin Against Pentylenetetrazole-induced Kindling and Associated Behavioral Comorbidities in Mice. India J. Pharma. Edu. Res., 2022, 56(4s), s659-s668.
[http://dx.doi.org/10.5530/ijper.56.4s.212]

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