Generic placeholder image

Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Research Article

Comparison of Computed Tomography Findings between Adult and Pediatric COVID-19 Patients

Author(s): Yeliz Dadalı, Sercan Özkaçmaz*, Erdal Ünlü, Ayşe Özkaçmaz, Muhammed Alparslan, İlyas Dündar, Ensar Turko, Mesut Özgökçe, Fatma Durmaz and Cemil Göya

Volume 20, 2024

Published on: 19 October, 2023

Article ID: e15734056248266 Pages: 7

DOI: 10.2174/0115734056248266230921072432

Price: $65

Abstract

Purpose: This study aims to compare chest computed tomography (CT) findings between adult and pediatric patients with coronavirus disease-19 (COVID-19) pneumonia.

Materials and Methods: This study included 30 pediatric patients aged 1 to 17 years and 30 adult patients over 18 years of age with COVID-19 pneumonia confirmed by reverse transcriptase-polymerase chain reaction (RT-PCR) who have findings related to COVID-19 on Chest Computed Tomography. The CT findings of adult and pediatric patients were compared with a z-test.

Results: Bilateral involvement (p:0.00056), involvement in all five lobes (p<0.00001), and central and peripheral involvement (p:0.01928) were significantly higher in the adult group compared to the pediatric group. In the pediatric group, the frequency of unilateral involvement (p:0.00056), involvement of solitary lobe (p:0.00132), and peripheral involvement (p: 0.01928) were significantly higher than in the adult group. The most common parenchymal finding in adults and pediatric patients was ground-glass opacities (100% and 83%, respectively). Among the parenchymal findings in adults, ground-glass opacities with consolidation (63%) were the second most common finding, followed by air bronchogram (60%) in adults, while in pediatric patients, halo sign (27%) and nodule (27%) were the second most common, followed by the ground-glass opacities with consolidation (23%).

Conclusion: The CT findings of pediatric COVID-19 patients must be well-known as the course of the disease is usually less severe, and the radiological findings are uncertain when compared with adults.

[1]
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395(10223): 497-506.
[http://dx.doi.org/10.1016/S0140-6736(20)30183-5] [PMID: 31986264]
[2]
Coronavirus disease (COVID-19) Situation Report – 155. 2019. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200623-covid-19-sitrep-155.pdf
[3]
Dosanjh A. Pediatric coronavirus disease 2019 and radiographic screening: Identification of patients at risk. Pediatr Allergy Immunol Pulmonol 2020; 33(2): 53-6.
[http://dx.doi.org/10.1089/ped.2020.1166] [PMID: 35921580]
[4]
Liguoro I, Pilotto C, Bonanni M, et al. SARS-COV-2 infection in children and newborns: A systematic review. Eur J Pediatr 2020; 179(7): 1029-46.
[http://dx.doi.org/10.1007/s00431-020-03684-7] [PMID: 32424745]
[5]
Palabiyik F, Kokurcan SO, Hatipoglu N, Cebeci SO, Inci E. Imaging of COVID-19 pneumonia in children. Br J Radiol 2020; 93(1113): 20200647.
[http://dx.doi.org/10.1259/bjr.20200647] [PMID: 32730110]
[6]
Steinberger S, Lin B, Bernheim A, et al. CT features of coronavirus disease (COVID-19) in 30 pediatric patients. AJR Am J Roentgenol 2020; 215(6): 1303-11.
[http://dx.doi.org/10.2214/AJR.20.23145] [PMID: 32442030]
[7]
Ghosh S, Deshwal H, Saeedan MB, Khanna VK, Raoof S, Mehta AC. Imaging algorithm for COVID-19: A practical approach. Clin Imaging 2021; 72: 22-30.
[http://dx.doi.org/10.1016/j.clinimag.2020.11.022] [PMID: 33197713]
[8]
Hani C, Trieu NH, Saab I, et al. COVID-19 pneumonia: A review of typical CT findings and differential diagnosis. Diagn Interv Imaging 2020; 101(5): 263-8.
[http://dx.doi.org/10.1016/j.diii.2020.03.014] [PMID: 32291197]
[9]
Kim H, Hong H, Yoon SH. Diagnostic performance of CT and reverse transcriptase polymerase chain reaction for coronavirus disease 2019: A meta-analysis. Radiology 2020; 296(3): E145-55.
[http://dx.doi.org/10.1148/radiol.2020201343] [PMID: 32301646]
[10]
Bernheim A, Mei X, Huang M, et al. Chest CT findings in coronavirus disease-19 (COVID-19): Relationship to duration of infection. Radiology 2020; 295(3): 200463.
[http://dx.doi.org/10.1148/radiol.2020200463] [PMID: 32077789]
[11]
Revel MP, Parkar AP, Prosch H, et al. COVID-19 patients and the radiology department – advice from the European Society of Radiology (ESR) and the European Society of Thoracic Imaging (ESTI). Eur Radiol 2020; 30(9): 4903-9.
[http://dx.doi.org/10.1007/s00330-020-06865-y] [PMID: 32314058]
[12]
American College of Radiology. ACR Recommendations for the use of Chest Radiography and Computed Tomography (CT) for Suspected COVID-19 Infection. 2020. Available from: https://www.acr.org/Advocacy-and-Economics/ACR-Position-Statements/Recommendations-for-Chest-Radiography-and-CT-for-Suspected-COVID19-Infection (Accesed on: 2020 April 3 15).
[13]
Kwee TC, Kwee RM. Chest CT in COVID-19: What the radiologist needs to know. Radiographics 2020; 40(7): 1848-65.
[http://dx.doi.org/10.1148/rg.2020200159] [PMID: 33095680]
[14]
Mantovani A, Rinaldi E, Zusi C, Beatrice G, Saccomani MD, Dalbeni A. Coronavirus disease 2019 (COVID-19) in children and/or adolescents: A meta-analysis. Pediatr Res 2021; 89(4): 733-7.
[http://dx.doi.org/10.1038/s41390-020-1015-2] [PMID: 32555539]
[15]
Awulachew E, Diriba K, Anja A, Getu E, Belayneh F. Computed Tomography (CT) imaging features of patients with COVID-19: Systematic review and meta-analysis. Radiol Res Pract 2020; 2020: 1023506.
[http://dx.doi.org/10.1155/2020/1023506]
[16]
Kumar J, Meena J, Yadav A, Yadav J. Radiological findings of COVID-19 in Children: A systematic review and meta-analysis. J Trop Pediatr 2021; 67(3): fmaa045.
[http://dx.doi.org/10.1093/tropej/fmaa045] [PMID: 32692815]
[17]
Bao C, Liu X, Zhang H, Li Y, Liu J. Coronavirus Disease 2019 (COVID-19) CT findings: A systematic review and meta-analysis. J Am Coll Radiol 2020; 17(6): 701-9.
[http://dx.doi.org/10.1016/j.jacr.2020.03.006] [PMID: 32283052]
[18]
Azadbakht J, Haghi-Aminjan H, Farhood B. Chest CT findings of COVID-19-infected patients, are there differences between pediatric and adult patients? A systematic review. Egypt J Radiol Nucl Med 2020; 51(1): 145.
[http://dx.doi.org/10.1186/s43055-020-00261-8]
[19]
Jain A, Patankar S, Kale S, Bairy A. Imaging of coronavirus disease (COVID-19): A pictorial review. Pol J Radiol 2021; 86: e4-e18.
[http://dx.doi.org/10.5114/pjr.2021.102609]
[20]
Duan Y, Zhu Y, Tang L, Qin J. CT features of novel coronavirus pneumonia (COVID-19) in children. Eur Radiol 2020; 30(8): 4427-33.
[http://dx.doi.org/10.1007/s00330-020-06860-3] [PMID: 32291501]
[21]
Cui X, Zhao Z, Zhang T, et al. A systematic review and meta-analysis of children with coronavirus disease 2019 (COVID-19). J Med Virol 2021; 93(2): 1057-69.
[http://dx.doi.org/10.1002/jmv.26398] [PMID: 32761898]
[22]
Savas R, Ceylan N. Radiological findings of COVID-19 pneumonia. Eurasian J Pulmonol 2020; 22(4): 19.
[http://dx.doi.org/10.4103/ejop.ejop_41_20]
[23]
Xia W, Shao J, Guo Y, Peng X, Li Z, Hu D. Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults. Pediatr Pulmonol 2020; 55(5): 1169-74.
[http://dx.doi.org/10.1002/ppul.24718] [PMID: 32134205]
[24]
Zhou S, Wang Y, Zhu T, Xia L. CT features of Coronavirus Disease 2019 (COVID-19) pneumonia in 62 patients in Wuhan, China. AJR Am J Roentgenol 2020; 214(6): 1287-94.
[http://dx.doi.org/10.2214/AJR.20.22975] [PMID: 32134681]
[25]
Walsh SLF, Roberton BJ. The atoll sign. Thorax 2010; 65(11): 1029-30.
[http://dx.doi.org/10.1136/thx.2010.139360] [PMID: 20820062]
[26]
Zang ST, Han X, Cui Q, Chang Q, Wu QJ, Zhao YH. Imaging characteristics of coronavirus disease 2019 (COVID-19) in pediatric cases: A systematic review and meta-analysis. Transl Pediatr 2021; 10(1): 1-16.
[http://dx.doi.org/10.21037/tp-20-281] [PMID: 33633932]
[27]
Chen Z, Fan H, Cai J, et al. High-resolution computed tomography manifestations of COVID-19 infections in patients of different ages. Eur J Radiol 2020; 126: 108972.
[http://dx.doi.org/10.1016/j.ejrad.2020.108972] [PMID: 32240913]
[28]
Nino G, Zember J, Sanchez-Jacob R, Gutierrez MJ, Sharma K, Linguraru MG. Pediatric lung imaging features of COVID-19: A systematic review and meta-analysis. Pediatr Pulmonol 2021; 56(1): 252-63.
[http://dx.doi.org/10.1002/ppul.25070] [PMID: 32926572]
[29]
Tan Y, Tan B, Pan J, Wu J, Zeng S, Wei H. Epidemiologic and clinical characteristics of 10 children with coronavirus disease 2019 in Changsha, China. J Clin Virol 2020; 127: 104353.
[http://dx.doi.org/10.1016/j.jcv.2020.104353] [PMID: 32302953]
[30]
Zarifian A, Ghasemi Nour M, Akhavan Rezayat A, Rahimzadeh Oskooei R, Abbasi B, Sadeghi R. Chest CT findings of coronavirus disease 2019 (COVID-19): A comprehensive meta-analysis of 9907 confirmed patients. Clin Imaging 2021; 70: 101-10.
[http://dx.doi.org/10.1016/j.clinimag.2020.10.035] [PMID: 33142125]
[31]
Lv H, Chen T, Pan Y, Wang H, Chen L, Lu Y. Pulmonary vascular enlargement on thoracic CT for diagnosis and differential diagnosis of COVID-19: A systematic review and meta-analysis. Ann Transl Med 2020; 8(14): 878.
[http://dx.doi.org/10.21037/atm-20-4955] [PMID: 32793722]
[32]
Wang C, Xiao X, Feng H, et al. Ongoing COVID-19 pandemic: A concise but updated comprehensive review. Curr Microbiol 2021; 78(5): 1718-29.
[http://dx.doi.org/10.1007/s00284-021-02413-z] [PMID: 33847795]
[33]
Katal S, Johnston SK, Johnston JH, Gholamrezanezhad A. Imaging findings of SARS-CoV-2 infection in pediatrics: A systematic review of coronavirus disease 2019 (COVID-19) in 850 patients. Acad Radiol 2020; 27(11): 1608-21.
[http://dx.doi.org/10.1016/j.acra.2020.07.031] [PMID: 32773328]
[34]
Ng MY, Lee EYP, Yang J, et al. Imaging profile of the COVID-19 infection: Radiologic findings and literature review. Radiol Cardiothorac Imaging 2020; 2(1): e200034.
[http://dx.doi.org/10.1148/ryct.2020200034]
[35]
Carotti M, Salaffi F, Sarzi-Puttini P, et al. Chest CT features of coronavirus disease 2019 (COVID-19) pneumonia: Key points for radiologists. Radiol Med 2020; 125(7): 636-46.
[http://dx.doi.org/10.1007/s11547-020-01237-4] [PMID: 32500509]
[36]
Xu X, Yu C, Qu J, et al. Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2. Eur J Nucl Med Mol Imaging 2020; 47(5): 1275-80.
[http://dx.doi.org/10.1007/s00259-020-04735-9] [PMID: 32107577]
[37]
Li Y, Cao J, Zhang X, Liu G, Wu X, Wu B. Chest CT imaging characteristics of COVID-19 pneumonia in preschool children: A retrospective study. BMC Pediatr 2020; 20(1): 227.
[http://dx.doi.org/10.1186/s12887-020-02140-7]
[38]
Yong SJ. Long COVID or post-COVID-19 syndrome: Putative pathophysiology, risk factors, and treatments. Infect Dis 2021; 53(10): 737-54.
[http://dx.doi.org/10.1080/23744235.2021.1924397] [PMID: 34024217]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy