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Current Functional Foods

Editor-in-Chief

ISSN (Print): 2666-8629
ISSN (Online): 2666-8637

Mini-Review Article

Review of Sacred Herbal Medicine Aegle marmelos: A Potent Metastasis Inhibitor

Author(s): Sagarika Dhamne and Sneha A. Agrawal*

Volume 2, Issue 1, 2024

Published on: 12 October, 2023

Article ID: e121023222129 Pages: 7

DOI: 10.2174/0126668629261606230919053847

Price: $65

Abstract

Aegle marmelos (A. marmelos) appears to be a significantly used ayurvedic medicine. This is a brilliantly composed nutritious fruit with carbohydrates, proteins, vitamins like riboflavin, thiamine, niacin, fatty acids, and minerals. Scientific studies have proved that A. marmelos has phytochemicals: carotenoids, phenolic, alkaloids, pectins, tannins, coumarins, flavonoids and terpenoids. Recent research on the effects of A. marmelos proved its anticancer, antimicrobial, cardioprotective, antidiabetic, and hepatoprotective activities. Extracts of various parts of plants such as leaves, bark, stems, fruits, and pulp subjected to preclinical studies conducted on cell lines showed apoptosis induction, inhibition of cell cycle and inhibition of proliferation of cells. Anti-cancer activity of A. marmelos was studied on selected cell lines of lung cancer, breast cancer, colon cancer and leukaemia. A. marmelos reported significant inhibitory effect on cell proliferation in cell line studies on A549, Ehrlich Ascites Carcinoma, MNU, DMBA, MCF-7, k562 cells, t-lymphoid Jurkat cells, b lymphoid Raji cells, erythroleukemic Hel cells, melanoma Colo 38 cells which supports the anticancer potential of it. Imperatorin has shown an antiproliferative effect on several cancer cell lines. The hydroethanolic extract of A. marmelos leaves showed a decrease in cell viability on A549 Human lung cancer cell line which works by fold change over control of the β-Catenin-m RNA and Wnt-mRNA expression of A549 and tumour growth suppression in DMBA induced carcinogenesis in rats. In human promyelocytic leukaemia, HL-60 cells, imperatorin from A. marmelos has caused cytochrome c-dependent apoptosis. Drugs interfere with the proliferative and survival signals that suppress the growth of K562 cells by blocking BCR-ABL1. Proper awareness, development of formulation and consumption of it make this drug scale up commercially.

Graphical Abstract

[1]
Bhattacherjee AK, Pandey D, Dikshit A. Nutraceutical profiling of some Indian bael (Aegle marmelos Correa) cultivars. Fruits 2019; 74(4): 187-93.
[http://dx.doi.org/10.17660/th2019/74.4.5]
[2]
Paramjeet K, Bhasin S, Dubey A, Nagar H, Sharma D. Sources and biological activity of coumarins: An appraisal. J Environ Sci Technol 2021; 7(1): 11-25.
[3]
Rajasekaran C, Meignanam E, Premkumar N, et al. In vitro evaluation of antibacterial activity of phytochemical extracts from leaves of Aegle marmelos (l.) corr. (rutaceae). Ethnobot Leafl 2008; 12: 1124-8.
[4]
Malviya R, Kumar A, Singh A, Kulkarni T. Pharmacological screening, ayurvedic values and commercial utility of Aegle marmelos. IJDDR 2012; 4(1): 28-37.
[5]
Gurjar PS, Bhattacherjee AK, Singh A, Dikshit A, Singh VK. Characterization of nutraceuticals in Bael powder prepared from fruits harvested at different developmental stages. IJTK 2019; 18(4): 724-30.
[6]
Bhattacherjee AK, Dikshit A, Kumar PC, Pandey D, Tandon DK. Profiling nutraceuticals in bael (Aegle marmelos (l.) correa) at various stages of fruit development. J Hortic Sci Biotechnol 2016; 91(2): 169-74.
[http://dx.doi.org/10.1080/14620316.2015.1133537]
[7]
Acharya S. Sharangadhar Samhita. Varanasi: Chaukhamba Orientalia 1950; pp. 254-6.
[8]
Mahato H, Kumar B. Medicinal uses with immense economic potential and nutritional properties of Aegle marmelos: A concise review. In: Biocomposites. IntechOpen 2022; pp. 1-24.
[http://dx.doi.org/10.5772/intechopen.102876]
[9]
Sharma N. Radha , Kumar M, et al Aegle marmelos (L.) correa: An underutilized fruit with high nutraceutical values: A review. Int J Mol Sci 2022; 23(18): 10889.
[http://dx.doi.org/10.3390/ijms231810889] [PMID: 36142805]
[10]
Manandhar B, Paudel KR, Sharma B, Karki R. Phytochemical profile and pharmacological activity of Aegle marmelos Linn. J Integr Med 2018; 16(3): 153-63.
[http://dx.doi.org/10.1016/j.joim.2018.04.007] [PMID: 29709412]
[11]
Aguirre G, Rodriguez AS, Flores-Lopez LZ, Parra-Hakka M, Somanathan YR. Asymmetric synthesis of naturally occurring â-hydroxamides(R)-tembamide and (R)-aegeline. J Mex Chem Soc 2001; 45(1): 21-4.
[12]
Sharma BR, Rattan RK, Sharma P. Marmelene, an alkaloid, and other components of unripe fruits of Aegle marmelos. Phytochemistry 1981; 20(11): 2606-7.
[http://dx.doi.org/10.1016/0031-9422(81)83112-3]
[13]
Ali MS, Pervez MK. Marmenol: A 7-geranyloxycoumarin from the leaves of Aegle marmelos corr. Nat Prod Res 2004; 18(2): 141-6.
[http://dx.doi.org/10.1080/14786410310001608037] [PMID: 14984087]
[14]
Chatterjee A, Bhattacharya A. 385. The isolation and constitution of marmin, a new coumarin from Aegle marmelos, Correa. J Chem Soc 1959; 0: 1922-4.
[http://dx.doi.org/10.1039/jr9590001922]
[15]
Cassady JM, Ojima N, Chang C, McLaughlin JL. An investigation of the antitumor activity of Micromelum integerrimum (Rutaceae). J Nat Prod 1979; 42(3): 274-8.
[http://dx.doi.org/10.1021/np50003a005] [PMID: 490172]
[16]
Wilzer KA, Fronczek FR, Urbatsch LE, Fischer NH. Coumarins from Aster praealtus. Phytochemistry 1989; 28(6): 1729-35.
[http://dx.doi.org/10.1016/S0031-9422(00)97834-8]
[17]
Sharma B, Sharma P. Constituents of Aegle marmelos. Planta Med 1981; 43(9): 102-3.
[http://dx.doi.org/10.1055/s-2007-971486] [PMID: 17402022]
[18]
Govindachari TR, Premila MS. Some alkaloids from Aegle marmelos. Phytochemistry 1983; 22(3): 755-7.
[http://dx.doi.org/10.1016/S0031-9422(00)86977-0]
[19]
Manandhar MD, Shoeb A, Kapil RS, Popli SP. New alkaloids from Aegle marmelos. Phytochemistry 1978; 17(10): 1814-5.
[http://dx.doi.org/10.1016/S0031-9422(00)88714-2]
[20]
Rahman UA, Zareen S, Choudhary MI, Shaheen F, Parvez M. Conformations of imperatorin. Acta Crystallogr Sect E Struct Rep Online 2004; 60(9): o1460-2.
[http://dx.doi.org/10.1107/S1600536804018604]
[21]
Kamalakkannan N, Stanely Mainzen Prince P. Effect of Aegle marmelos Correa. (Bael) fruit extract on tissue antioxidants in streptozotocin diabetic rats. Indian J Exp Biol 2003; 41(11): 1285-8.
[PMID: 15332498]
[22]
Nadkarni KM. Indian materia medica. Bombay: India: Popular Prakashan 1992; 1: 45-82.
[23]
Rastogi RP, Mehrotra BN. Compendium of Indian medicinal plants. New Delhi: Publication and Information Directorate 1991; 2: 17-32.
[24]
Baliga MS, Bhat HP, Joseph N, Fazal F. Phytochemistry and medicinal uses of the bael fruit (Aegle marmelos Correa): A concise review. Food Res Int 2011; 44(7): 1768-75.
[http://dx.doi.org/10.1016/j.foodres.2011.02.008]
[25]
Rahman S, Parvin R. Therapeutic potential of Aegle marmelos (L.)-An overview. Asian Pac J Trop Dis 2014; 4(1): 71-7.
[http://dx.doi.org/10.1016/S2222-1808(14)60318-2]
[26]
Sharma GN, Dubey SK, Sharma P, Sati N. Medicinal values of bael (Aegle marmelos) (l.) corr.: A review. IJCPR 2011; 1(3): 12-22.
[27]
Al-Amiery A, Al-Majedy Y, Al-Duhaidahawi D, Amir Kadhum A, Bakar Mohamad A. Green antioxidants: Synthesis and scavenging activity of coumarin-thiadiazoles as potential antioxidants complemented by molecular modeling studies. Free Radic Antioxid 2016; 6(2): 173-7.
[http://dx.doi.org/10.5530/fra.2016.2.7]
[28]
Al-Amiery A, Al-Majedy Y, Kadhum A, Mohamad A. New coumarin derivative as an eco-friendly inhibitor of corrosion of mild steel in Acid medium. Molecules 2014; 20(1): 366-83.
[http://dx.doi.org/10.3390/molecules20010366] [PMID: 25551187]
[29]
Al-Majedy Y, Kadhum A, Al-Amiery A, Mohamad A. Synthesis and characterization of some new 4-hydroxy-coumarin derivatives. Molecules 2014; 19(8): 11791-9.
[http://dx.doi.org/10.3390/molecules190811791] [PMID: 25105917]
[30]
Al-Majedy YK, Al-Amiery AA, Kadhum AAH, Mohamad AB. Efficient catalyst one-pot synthesis of 7-(Aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives complemented by antibacterial activity. BioMed Res Int 2016; 2016: 1-7.
[http://dx.doi.org/10.1155/2016/5891703] [PMID: 27563671]
[31]
Al-Amiery AA, Kadhum AAH, Mohamad AB. Antifungal activities of new coumarins. Molecules 2012; 17(5): 5713-23.
[http://dx.doi.org/10.3390/molecules17055713] [PMID: 22628043]
[32]
Al-Majedy YK, Al-Amiery AA, Kadhum AAH, Mohamad AB. Antioxidant activities of 4-methylumbelliferone derivatives. PLoS One 2016; 11(5): e0156625.
[http://dx.doi.org/10.1371/journal.pone.0156625] [PMID: 27243231]
[33]
Annunziata F, Pinna C, Dallavalle S, Tamborini L, Pinto A. An overview of coumarin as a versatile and readily accessible scaffold with broad-ranging biological activities. Int J Mol Sci 2020; 21(13): 4618.
[http://dx.doi.org/10.3390/ijms21134618] [PMID: 32610556]
[34]
Kini SG, Choudhary S, Mubeen M. Synthesis, docking study and anticancer activity of coumarin substituted derivatives of benzothiazole. J Comput Methods Mol Des 2012; 2(1): 51-60.
[35]
Xu L, Wu Y L, Zhao X Y, Zhang W. The study on biological and pharmacological activity of coumarins. AP3ER 2015; 135-8.
[http://dx.doi.org/10.2991/ap3er-15.2015.33]
[36]
Jalhan S, Singh S, Saini R, Sethi NS, Jain UK. Review article: Various biological activities of coumarin and oxadiazole derivatives. Asian J Pharm Clin Res 2017; 10(7): 38-43.
[http://dx.doi.org/10.22159/ajpcr.2017.v10i7.18461]
[37]
Kesari AN, Gupta RK, Singh SK, Diwakar S, Watal G. Hypoglycemic and antihyperglycemic activity of Aegle marmelos seed extract in normal and diabetic rats. J Ethnopharmacol 2006; 107(3): 374-9.
[http://dx.doi.org/10.1016/j.jep.2006.03.042] [PMID: 16781099]
[38]
Shoba FG, Thomas M. Study of antidiarrhoeal activity of four medicinal plants in castor-oil induced diarrhoea. J Ethnopharmacol 2001; 76(1): 73-6.
[http://dx.doi.org/10.1016/S0378-8741(00)00379-2] [PMID: 11378284]
[39]
Joshi PV, Patil RH, Maheshwari VL. In vitro antidiarrhoeal activity and toxicity profile of Aegle marmelos Correa ex Roxb. dried fruit pulp. Nat Prod Radiance 2009; 8(5): 498-502.
[40]
Mazumder R, Bhattacharya S, Mazumder A, Pattnaik AK, Tiwary PM, Chaudhary S. Antidiarrhoeal evaluation of Aegle marmelos (correa) linn. root extract. Phytother Res 2006; 20(1): 82-4.
[http://dx.doi.org/10.1002/ptr.1804] [PMID: 16397850]
[41]
Rao GHJ, Lakshmi P. Evaluation of antidiarrhoeal activity of extract from leaves of Aegle marmelos. J Appl Pharm Sci 2012; 02(2): 75-8.
[42]
Benni J, Suresha RN, Jayanthi MK. Evaluation of the anti-inflammatory activity of Aegle marmelos (Bilwa) root. Indian J Pharmacol 2011; 43(4): 393-7.
[http://dx.doi.org/10.4103/0253-7613.83108] [PMID: 21844992]
[43]
Pynam H, Dharmesh SM. Antioxidant and anti-inflammatory properties of marmelosin from Bael (Aegle marmelos L.); Inhibition of TNF-α mediated inflammatory/tumor markers. Biomed Pharmacother 2018; 106: 98-108.
[http://dx.doi.org/10.1016/j.biopha.2018.06.053] [PMID: 29957472]
[44]
Bhavani R. Antidiabetic activity medicinal plant Aegle marmelos (linn.) on alloxan induced diabetic rats. Int J Pharma Bio Sci 2014; 1(1): 36-44.
[45]
Bhavna S, Partha R, Roy P. Hypoglycemic and hypolipidemic effect of Aegle marmelos (L.) leaf extract on streptozotocin induced diabetic mice. Int J Pharmacol 2007; 3(6): 444-52.
[http://dx.doi.org/10.3923/ijp.2007.444.452]
[46]
Arumugama S, Kavimani S, Kadalmani B, Bakrudeen Ali Ahmed A, Abdulkadar Akbarsha M, Venkateswara Rao M. Antidiabetic activity of leaf and callus extracts of Aegle marmelos in rabbit. Sci Asia 2008; 34(3): 317-21.
[http://dx.doi.org/10.2306/scienceasia1513-1874.2008.34.317]
[47]
Kamalakkannan N, Stanely Mainzen Prince P. Antihyperlipidaemic effect of Aegle marmelos fruit extract in streptozotocin-induced diabetes in rats. J Sci Food Agric 2005; 85(4): 569-73.
[http://dx.doi.org/10.1002/jsfa.1978]
[48]
Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol 2002; 81(1): 81-100.
[http://dx.doi.org/10.1016/S0378-8741(02)00059-4] [PMID: 12020931]
[49]
Ibrahim M, Parveen B, Zahiruddin S, et al. Analysis of polyphenols in Aegle marmelos leaf and ameliorative efficacy against diabetic mice through restoration of antioxidant and anti‐inflammatory status. J Food Biochem 2022; 46(4): 1-15.
[http://dx.doi.org/10.1111/jfbc.13852] [PMID: 34250628]
[50]
Rana BK, Singh UP, Taneja V. Antifungal activity and kinetics of inhibition by essential oil isolated from leaves of Aegle marmelos. J Ethnopharmacol 1997; 57(1): 29-34.
[http://dx.doi.org/10.1016/S0378-8741(97)00044-5] [PMID: 9234162]
[51]
Rahman A, Imran H, Iqbal L. STaqvi SI, Fatima N, Yaqeen Z. Dry and ripe fruit of Aegle marmelos. L: A potent source of antioxidant, lipoxygenase inhibitors and free radical scavenger. Pak J Pharm Sci 2016; 29(4): 1127-31.
[PMID: 27393425]
[52]
Bera K, Ray S, Raja W, Ray B. Structural insight of an antioxidative arabinogalactan protein of Aegle marmelos fruit gum and it’s interaction with β-lactoglobulin. Int J Biol Macromol 2017; 99: 300-7.
[http://dx.doi.org/10.1016/j.ijbiomac.2017.02.068] [PMID: 28254574]
[53]
Ramakrishna YG, Savithri K, Kist M, Devaraj SN. Aegle marmelos fruit extract attenuates helicobacter pylori lipopolysaccharide induced oxidative stress in sprague dawley rats. BMC Complement Altern Med 2015; 15(1): 375.
[http://dx.doi.org/10.1186/s12906-015-0915-x] [PMID: 26482072]
[54]
Patel PK, Sahu J, Sahu L, Prajapati NK, Dubey BK. Aegle marmelos: A review on its medicinal properties. Int J Pharm Phytopharmacol Res 2012; 1(5): 332-41.
[55]
Mathur G, Nain S, Sharma PK. Cancer: An overview. Acad J Cancer Res 2015; 8(1): 1-9.
[http://dx.doi.org/10.5829/idosi.ajcr.2015.8.1.9336]
[57]
Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin 2022; 72(1): 7-33.
[http://dx.doi.org/10.3322/caac.21708] [PMID: 35020204]
[58]
Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003; 3(10): 768-80.
[http://dx.doi.org/10.1038/nrc1189] [PMID: 14570043]
[59]
Parmar J, Sharma P, Verma P, Goyal PK, Goyal PK. Chemopreventive action of Syzygium cumini on DMBA-induced skin papillomagenesis in mice. Asian Pac J Cancer Prev 2010; 11(1): 261-5.
[PMID: 20593968]
[61]
GLOBOCAN 2020: New Global Cancer Data. 2020. Available from:[ https://www.uicc.org/news/globocan-2020-new-global-cancer-data
[62]
Shah R, Rosso K, Nathanson SD. Pathogenesis, prevention, diagnosis and treatment of breast cancer. World J Clin Oncol 2014; 5(3): 283-98.
[http://dx.doi.org/10.5306/wjco.v5.i3.283] [PMID: 25114845]
[63]
Kim J, Lee J, Jung SY, Kim J. Dietary factors and female breast cancer risk: A prospective cohort study. Nutrients 2017; 9(12): 1331.
[http://dx.doi.org/10.3390/nu9121331] [PMID: 29215604]
[64]
Fentiman IS, D’Arrigo C. Pathogenesis of breast carcinoma. Int J Clin Pract 2004; 58(1): 35-40.
[http://dx.doi.org/10.1111/j.1368-5031.2003.0091.x] [PMID: 14994969]
[65]
Parada H Jr, Steck SE, Bradshaw PT, et al. Grilled, barbecued, and smoked meat intake and survival following breast cancer. J Natl Cancer Inst 2017; 109(6): djw299.
[http://dx.doi.org/10.1093/jnci/djw299] [PMID: 28052933]
[66]
Lee DG, Burstyn I, Lai AS, et al. Women’s occupational exposure to polycyclic aromatic hydrocarbons and risk of breast cancer. Occup Environ Med 2019; 76(1): 22-9.
[http://dx.doi.org/10.1136/oemed-2018-105261] [PMID: 30541747]
[67]
Rodgers KM, Udesky JO, Rudel RA, Brody JG. Environmental chemicals and breast cancer: An updated review of epidemiological literature informed by biological mechanisms. Environ Res 2018; 160: 152-82.
[http://dx.doi.org/10.1016/j.envres.2017.08.045] [PMID: 28987728]
[68]
Key TJ, Verkasalo PK, Banks E. Epidemiology of breast cancer. Lancet Oncol 2001; 2(3): 133-40.
[http://dx.doi.org/10.1016/S1470-2045(00)00254-0] [PMID: 11902563]
[69]
Watkins EJ. Overview of breast cancer. JAAPA 2019; 32(10): 13-7.
[http://dx.doi.org/10.1097/01.JAA.0000580524.95733.3d] [PMID: 31513033]
[70]
Lung cancer statistics. 2020. Available from: [https://www.wcrf.org/cancer-trends/lung-cancer-statistics/
[71]
Dela Cruz CS, Tanoue LT, Matthay RA. Lung cancer: Epidemiology, etiology, and prevention. Clin Chest Med 2011; 32(4): 605-44.
[http://dx.doi.org/10.1016/j.ccm.2011.09.001] [PMID: 22054876]
[72]
Miller YE. Pathogenesis of lung cancer: 100 year report. Am J Respir Cell Mol Biol 2005; 33(3): 216-23.
[http://dx.doi.org/10.1165/rcmb.2005-0158OE] [PMID: 16107574]
[73]
Popper HH. Progression and metastasis of lung cancer. Cancer Metastasis Rev 2016; 35(1): 75-91.
[http://dx.doi.org/10.1007/s10555-016-9618-0] [PMID: 27018053]
[74]
Kumar NB, Sridevi G, Selvaraj R, Preetha S. Studies on chemotherapeutic potential of hydroethanolic leaf extract of Aegle marmelos on human lung cancer cell lines. J Pharm Res Int 2021; 33(64A): 325-32.
[http://dx.doi.org/10.9734/jpri/2021/v33i64A35706]
[75]
Devendrapandi G, Sahay MI, Padmanaban D, et al. Biogenic synthesis of gold nanoparticles using bael fruit juice and its efficacy against human A-549 lung cancer cell line. Inorg Chem Commun 2023; 151: 110636.
[http://dx.doi.org/10.1016/j.inoche.2023.110636]
[76]
Akhouri V, Kumari M, Kumar A. Therapeutic effect of Aegle marmelos fruit extract against DMBA induced breast cancer in rats. Sci Rep 2020; 10(1): 18016.
[http://dx.doi.org/10.1038/s41598-020-72935-2] [PMID: 33093498]
[77]
Dhivya S, Devi RG, Selvaraj J, Priya AJ. Regulation of chloride intracellular channel protein 1 and caspase -3 mRNA expression by hydroethanolic extract of Aegle marmelos fruit human breast cancer cell Line-MCF-7. J Pharm Res Int 2021; 33(47B): 586-93.
[http://dx.doi.org/10.9734/jpri/2021/v33i47B33158]
[78]
Bhatti R, Singh J, Saxena AK, Suri N, Ishar MP. Pharmacognostic standardisation and antiproliferative activity of Aegle marmelos (L.) Correa leaves in various human cancer cell lines. Indian J Pharm Sci 2013; 75(6): 628-34.
[PMID: 24591736]
[79]
Jagetia GC, Venkatesh P, Baliga MS. Aegle marmelos (L.) Correa inhibits the proliferation of transplanted Ehrlich ascites carcinoma in mice. Biol Pharm Bull 2005; 28(1): 58-64.
[http://dx.doi.org/10.1248/bpb.28.58] [PMID: 15635164]
[80]
Venkatesh P, Shantala B, Jagetia GC, Rao KK, Baliga MS. Modulation of doxorubicin-induced genotoxicity by Aegle marmelos in mouse bone marrow: A micronucleus study. Integr Cancer Ther 2007; 6(1): 42-53.
[http://dx.doi.org/10.1177/1534735406298302] [PMID: 17351026]
[81]
Verma S, Bahorun T, Singh RK, Aruoma OI, Kumar A. Effect of Aegle marmelos leaf extract on N -methyl N -nitrosourea-induced hepatocarcinogensis in Balb/c mice. Pharm Biol 2013; 51(10): 1272-81.
[http://dx.doi.org/10.3109/13880209.2013.786100] [PMID: 23855803]
[82]
Chockalingam V, Kadali SDVS, Gnanasambantham P. Antiproliferative and antioxidant activity of Aegle marmelos (Linn.) leaves in Dalton′s Lymphoma Ascites transplanted mice. Indian J Pharmacol 2012; 44(2): 225-9.
[http://dx.doi.org/10.4103/0253-7613.93854] [PMID: 22529480]
[83]
George SK, Radhakrishnan R, Kumar SS, Sreelekha TT, Balaram P. Chemopreventive efficacy of Aegle marmelos on murine transplantable tumors. Integr Cancer Ther 2014; 13(1): 68-78.
[http://dx.doi.org/10.1177/1534735413490234] [PMID: 23729467]
[84]
Husain Khan T, Sultana S. Effect of Aegle marmelos on DEN initiated and 2-AAF promoted hepatocarcinogenesis: A chemopreventive study. Toxicol Mech Methods 2011; 21(6): 453-62.
[http://dx.doi.org/10.3109/15376516.2011.564677] [PMID: 21417629]
[85]
Agrawal A, Verma P, Goyal PK. Chemomodulatory effects of Aegle marmelos against DMBA-induced skin tumorigenesis in Swiss albino mice. Asian Pac J Cancer Prev 2010; 11(5): 1311-4.
[PMID: 21198283]
[86]
Agrawal A, Jahan S, Goyal PK. Chemically induced skin carcinogenesis in mice and its prevention by Aegle marmelos (an Indian medicinal plant) fruit extract. J Environ Pathol Toxicol Oncol 2011; 30(3): 251-9.
[http://dx.doi.org/10.1615/JEnvironPatholToxicolOncol.v30.i3.80] [PMID: 22126618]
[87]
Agrawal A, Jahan S, Soyal D, Goyal E, Goyal PK. Amelioration of chemical-induced skin carcinogenesis by Aegle marmelos, an Indian medicinal plant, fruit extract. Integr Cancer Ther 2012; 11(3): 257-66.
[http://dx.doi.org/10.1177/1534735411417127] [PMID: 21862519]
[88]
Lampronti I, Martello D, Bianchi N, et al. In vitro antiproliferative effects on human tumor cell lines of extracts from the Bangladeshi medicinal plant Aegle marmelos Correa. Phytomedicine 2003; 10(4): 300-8.
[http://dx.doi.org/10.1078/094471103322004794] [PMID: 12809360]
[89]
Gupta N, Agrawal RC, Sharma P, Narwariya A. Anticancer potential of Aegle marmelos bark extract against DMBA induced skin papillomagenesis with reference to oxidative stress. EJPMR 2016; 3(4): 309-14.
[90]
Savita, Singh AP, Singh AP. Aegle marmelos (L.) (Bael): A systematic review. J Drug Deliv Ther 2021; 11(3-S): 131-6.
[http://dx.doi.org/10.22270/jddt.v11i3-S.4834]
[91]
Swarnkar R, Singh D, Choudhary A, Anand S, Rathore A, Jediya HK. Pharmacological properties of Aegle marmelos: A review. Int J Curr Microbiol Appl Sci 2019; 8(5): 1600-8.
[http://dx.doi.org/10.20546/ijcmas.2019.805.185]

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  • Booting (99.31ms)time
  • Application (177ms)time
  • 1 x Application (64.08%)
    177ms
    1 x Booting (35.92%)
    99.31ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    36 statements were executed, 4 of which were duplicates, 32 unique. Show only duplicated93.78ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('309679543','',1,1740497783,1740497783) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740497783
      1.14msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('309679543','/article/135174',1,1740497783,1740497783)
      220μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 309679543 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309679543) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 309679543 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309679543) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 309679543 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309679543) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 309679543 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309679543) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 309679543 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309679543) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 309679543 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309679543) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 309679543 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309679543) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 309679543 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309679543) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 309679543 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309679543) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 309679543 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309679543) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 309679543 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309679543) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 309679543 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309679543) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 309679543 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309679543) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 309679543 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309679543) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 309679543 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309679543) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 309679543 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309679543) limit 1
      12.41msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 309679543
      • 1: 309679543
      • 2: 309679543
      • 3: 309679543
      • 4: 309679543
      • 5: 309679543
      • 6: 309679543
      • 7: 309679543
      • 8: 309679543
      • 9: 309679543
      • 10: 309679543
      • 11: 309679543
      • 12: 309679543
      • 13: 309679543
      • 14: 309679543
      • 15: 309679543
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=135174
      640μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 204 limit 1
      400μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 204
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=204) and sj.journal_id!=204 group by `j`.`nid`) as `aggregate_table`
      890μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=204) and sj.journal_id!=204 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      520μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=204) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      780μsalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=204) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      750μsalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '135174'
      210μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 135174
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '135174'
      3.6msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 135174
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '135174' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      2.47msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 135174
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      220μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      450μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 204 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      24.13msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 204 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      1.81msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 204 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      730μsalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 135174 limit 1
      160μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 135174
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 135174 and content_type = 'article' order by status desc limit 1
      220μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 222129 limit 1
      190μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 222129
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      240μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CFF' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      300μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CFF
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '135174' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      440μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '13040' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      340μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3484' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      300μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309679543 and j.to_ip >=309679543 )) and ((j.from_date <= 1740497783 and j.to_date >= 1740497783 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3484) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309679543 and j.to_ip >=309679543 )) and ((j.from_date <= 1740497783 and j.to_date >= 1740497783 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3484) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309679543 and j.to_ip >=309679543 )) and ((j.from_date <= 1740497783 and j.to_date >= 1740497783 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3484)
      29.88msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309679543 and j.to_ip >=309679543 )) and ((j.from_date <= 1740497783 and j.to_date >= 1740497783 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13040) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309679543 and j.to_ip >=309679543 )) and ((j.from_date <= 1740497783 and j.to_date >= 1740497783 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13040) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309679543 and j.to_ip >=309679543 )) and ((j.from_date <= 1740497783 and j.to_date >= 1740497783 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13040)
      760μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309679543 and j.to_ip >=309679543 )) and ((j.from_date <= 1740497783 and j.to_date >= 1740497783 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 135174) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309679543 and j.to_ip >=309679543 )) and ((j.from_date <= 1740497783 and j.to_date >= 1740497783 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 135174) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309679543 and j.to_ip >=309679543 )) and ((j.from_date <= 1740497783 and j.to_date >= 1740497783 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 135174)
      640μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '81' and is_uploaded = 1 and issue_id = 13040 order by cast(first_page as SIGNED) desc limit 1
      520μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 81
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '87' and is_uploaded = 1 and issue_id = 13040 order by cast(first_page as SIGNED) asc limit 1
      460μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 87
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      240μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      310μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 135174 limit 1
      3.8msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 135174
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 204 and `b`.`banner_from_date` <= 1740497783 and `b`.`banner_to_date` >= 1740497783 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.69msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 204
      • 3: 1740497783
      • 4: 1740497783
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 204 and `b`.`banner_from_date` <= 1740497783 and `b`.`banner_to_date` >= 1740497783 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.63msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 204
      • 3: 1740497783
      • 4: 1740497783
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='229619932b7b054b80a28d0adadd278b'
      290μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        tJTLROJqN95fmNKFqbAcELUAdkbXh7eWpR9wiHnD
        uc_cart_id
        229619932b7b054b80a28d0adadd278b
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/135174" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/135174
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:9 [ "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6ImpkeWFyMzNzdXhjaUZCelluZ0MyeFE9PSIsInZhbHVlIjoiK3hhMlB1RWI0M2dXRXUreHUzZGRQSEhuYnlvQVNIYTdrSGJYTFM3c1J0UT0iLCJtYWMiOiJiOTIwMjZiY2E3OTE2NzUzM2NjZDUwYTA3NmI4ZjM0MmM4YTkzMDVkYWYwMzA1NmY0ZjIyYmI5MWYyMzk4MDY5IiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6ImpkeWFyMzNzdXhjaUZCelluZ0MyeFE9PSIsInZhbHVlIjoiK3hhMlB1RWI0M2dXRXUreHUzZGRQSEhuYnlvQVNIYTdrSGJYTFM3c1J0UT0iLCJtYWMiOiJiOTIwMjZiY2E3OTE2" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
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