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Anti-Infective Agents

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ISSN (Print): 2211-3525
ISSN (Online): 2211-3533

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Mini-Review Article

A Review on Emerging Impact of Antitubercular Activity of 1,2,4-Triazole Derivatives

Author(s): Vedavathi Rangaswamy and Umesh Laddi*

Volume 22, Issue 1, 2024

Published on: 11 October, 2023

Article ID: e111023222113 Pages: 16

DOI: 10.2174/0122113525268198230921071016

Price: $65

Abstract

The present review aims to summarize the antitubercular profile of 1,2,4-triazole, one of the emerging entitled and most sought scaffold with a wide spectrum of biological and pharmacological activities. A systematic review of literature on ‘Heterocycles’, establishes the fact that 1,2,4-triazoles and their derivatives exhibit diverse activities. The 1,2,4-triazole core is found in therapeutically significant drugs and many new ones are in the pipeline. ‘Triazole pharmacophore’ has replaced the widely used ‘imidazole’ as ‘systemically integral azole’ by connecting synchronicity with serendipity. Triazoles are penetratingly studied as ‘diverse therapeutic agents’, due to the improved efficacy and reduced side effects. The extensive anthology of work carried out in the last two decades on 1,2,4-triazole moiety will provide imminent scope for the development of novel potential drugs having better efficacy, selectivity and reduced toxicity.

Graphical Abstract

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