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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

Antiviral Effects and Mechanisms of Green Tea Catechins on Influenza: A Perception on Combating Symptoms from COVID-19

Author(s): Gene Chi Wai Man*, Xu Zheng, Sze Wan Hung, Loucia Kit Ying Chan, Tao Zhang, Xiaoyan Chen, Kai On Chu, Ian Chung Yuen Huen, Darren Wang Yip Lui, Alfred Ding Wong and Chi Chiu Wang

Volume 24, Issue 1, 2024

Published on: 10 October, 2023

Page: [60 - 73] Pages: 14

DOI: 10.2174/0115680266251803230925075508

Price: $65

Abstract

Over the centuries, influenza and its associated epidemics have been a serious public health problem. Although vaccination and medications (such as neuraminidase inhibitors) are the mainstay of pharmacological approaches to prevent and treat influenza, however, frequent mutations in the influenza genome often result in treatment failure and resistance to standard medications which limit their effectiveness. In recent years, green tea catechins have been evaluated as potential anti-influenza agents. Herein, in this review, we highlighted the effects and mechanisms underlying the inhibitory effects of epigallocatechin 3-gallate (EGCG), the most abundant ingredient in green tea, against different influenza viral infections, and their clinical benefits toward prevention and treatment. In addition, as the severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) causes the outbreak of COVID-19 pandemic, our review also delineates the current perspective on SARS-CoV-2 and future insights as to the potential application of EGCG on suppressing the flu-like symptoms caused by COVID-19.

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