Abstract
Species of genus Morus (family Moraceae) have been used as traditional medicinal and edible resources since ancient times. Genus Morus has been acknowledged as a promising resource for the exploration of novel compounds with various bioactivities. Phytochemical investigations of the genus have led to the discovery of more than approximately 453 natural products from 2011 to 2023, mainly including flavonoids, Diels-Alder adducts, 2-arylbenzfuran, alkaloids and stilbenes. Bioactive constituents and extracts of this genus displayed a wide range of impressive biological properties including antidiabetic, anti-inflammatory, antioxidant, anti-cancer, hepatoprotective, renoprotective, and some other activities. Herein, the research progress of this genus Morus from 2011 to 2023 on phytochemistry and pharmacology are systematically presented and discussed for the first time. This current review provides the easiest access to the information on genus Morus for readers and researchers in view of enhancing the continuity on research done on this genus.
Graphical Abstract
[http://dx.doi.org/10.1023/A:1003066613099]
[PMID: 26850343]
[http://dx.doi.org/10.1007/s11418-019-01383-8] [PMID: 31897975]
[http://dx.doi.org/10.1080/10286020.2014.923405] [PMID: 24911924]
[http://dx.doi.org/10.1080/10286020.2014.923407] [PMID: 24965853]
[http://dx.doi.org/10.3390/molecules22020236]
[http://dx.doi.org/10.1002/ptr.5926] [PMID: 29024160]
[http://dx.doi.org/10.1016/j.jff.2015.03.053]
[http://dx.doi.org/10.1007/s12011-016-0696-1] [PMID: 27071614]
[http://dx.doi.org/10.3892/mmr.2020.11615] [PMID: 33173971]
[http://dx.doi.org/10.38212/2224-6614.1223] [PMID: 31883611]
[http://dx.doi.org/10.1007/s11011-017-0089-y] [PMID: 28822021]
[http://dx.doi.org/10.1016/j.ijbiomac.2020.02.300] [PMID: 32112846]
[http://dx.doi.org/10.1016/j.neulet.2016.11.036] [PMID: 27871994]
[http://dx.doi.org/10.1016/j.lfs.2012.11.020] [PMID: 23270943]
[http://dx.doi.org/10.1089/jmf.2014.3196] [PMID: 25514545]
[http://dx.doi.org/10.1016/j.jff.2012.01.006]
[http://dx.doi.org/10.1080/01635581.2013.809127] [PMID: 24087992]
[http://dx.doi.org/10.1080/14786419.2018.1491041] [PMID: 30369248]
[http://dx.doi.org/10.1021/acs.jafc.0c02720] [PMID: 32650643]
[http://dx.doi.org/10.1007/s13659-022-00355-y] [PMID: 36050566]
[http://dx.doi.org/10.1080/14786419.2018.1443095] [PMID: 29516755]
[http://dx.doi.org/10.1155/2013/380692] [PMID: 24023529]
[http://dx.doi.org/10.1002/pca.1270] [PMID: 21046687]
[http://dx.doi.org/10.1080/10286020.2014.900047] [PMID: 24679096]
[http://dx.doi.org/10.1080/14786419.2012.676547] [PMID: 22480349]
[http://dx.doi.org/10.1590/0001-3765201720160660] [PMID: 29236863]
[http://dx.doi.org/10.1039/C6FO00370B] [PMID: 27241036]
[http://dx.doi.org/10.1021/jf200423g] [PMID: 21434689]
[http://dx.doi.org/10.3390/molecules16076010] [PMID: 21772233]
[http://dx.doi.org/10.1016/j.bmcl.2011.03.060] [PMID: 21511472]
[http://dx.doi.org/10.1021/np100638h] [PMID: 21319773]
[http://dx.doi.org/10.1021/np100907d] [PMID: 21401118]
[http://dx.doi.org/10.1371/journal.pone.0050619] [PMID: 23185641]
[http://dx.doi.org/10.1016/j.fitote.2012.06.001] [PMID: 22698714]
[http://dx.doi.org/10.1080/10286020.2011.650917] [PMID: 22332774]
[http://dx.doi.org/10.1371/journal.pone.0071144] [PMID: 23936259]
[http://dx.doi.org/10.1002/cbdv.201400210] [PMID: 26080739]
[http://dx.doi.org/10.1080/10286020.2015.1035714] [PMID: 26121569]
[http://dx.doi.org/10.1002/cbdv.201500005] [PMID: 26567954]
[http://dx.doi.org/10.3390/molecules20058730] [PMID: 26007176]
[http://dx.doi.org/10.1016/j.bmcl.2015.04.045] [PMID: 25935644]
[http://dx.doi.org/10.3390/molecules21091112] [PMID: 27563860]
[http://dx.doi.org/10.3390/molecules21091130] [PMID: 27598113]
[http://dx.doi.org/10.1016/j.bmcl.2016.11.046] [PMID: 27908762]
[http://dx.doi.org/10.1080/14786419.2017.1327862] [PMID: 28521570]
[http://dx.doi.org/10.1016/j.fitote.2017.05.004] [PMID: 28529178]
[http://dx.doi.org/10.1016/j.fitote.2017.09.006] [PMID: 28916258]
[http://dx.doi.org/10.1080/10286020.2017.1343303] [PMID: 28644689]
[http://dx.doi.org/10.1080/14786419.2017.1354190] [PMID: 28722505]
[PMID: 29976416]
[http://dx.doi.org/10.1016/j.ejmech.2017.12.057] [PMID: 29291443]
[http://dx.doi.org/10.1016/j.phymed.2017.12.023] [PMID: 29433688]
[http://dx.doi.org/10.1016/j.phytochem.2018.08.001] [PMID: 30103164]
[http://dx.doi.org/10.1016/j.fitote.2018.02.004] [PMID: 29427594]
[http://dx.doi.org/10.1039/C9FO01457H] [PMID: 31588440]
[http://dx.doi.org/10.1016/j.fitote.2021.105018] [PMID: 34450202]
[http://dx.doi.org/10.1021/acs.jnatprod.1c00403] [PMID: 34279099]
[http://dx.doi.org/10.1016/j.fitote.2014.08.010] [PMID: 25128426]
[http://dx.doi.org/10.1016/j.phytochem.2019.03.029] [PMID: 30986688]
[http://dx.doi.org/10.1055/s-0030-1270745] [PMID: 21308616]
[http://dx.doi.org/10.1016/j.bmcl.2011.06.020] [PMID: 21737271]
[http://dx.doi.org/10.1021/np401025f] [PMID: 24901948]
[http://dx.doi.org/10.1007/s12272-015-0613-8] [PMID: 25981820]
[http://dx.doi.org/10.1016/j.phytochem.2016.12.006] [PMID: 27974159]
[http://dx.doi.org/10.3390/molecules22040514] [PMID: 28333105]
[http://dx.doi.org/10.1080/10286020.2017.1350653] [PMID: 29191050]
[http://dx.doi.org/10.1080/14786419.2017.1309535] [PMID: 28349742]
[http://dx.doi.org/10.1016/j.ejmech.2017.11.087] [PMID: 29275228]
[http://dx.doi.org/10.1007/s12272-020-01269-4] [PMID: 32978714]
[http://dx.doi.org/10.1039/D3OB00225J] [PMID: 36920451]
[http://dx.doi.org/10.1080/14786419.2023.2189710] [PMID: 36927252]
[http://dx.doi.org/10.1021/acs.jafc.3c00776] [PMID: 37265398]
[http://dx.doi.org/10.1055/s-0031-1280338] [PMID: 22083899]
[http://dx.doi.org/10.5650/jos.61.585] [PMID: 23018855]
[http://dx.doi.org/10.1021/np2007318] [PMID: 22165973]
[http://dx.doi.org/10.1080/14786419.2014.951852] [PMID: 25174266]
[http://dx.doi.org/10.1080/10286020903501577] [PMID: 20390764]
[http://dx.doi.org/10.1016/j.phytol.2018.11.002]
[http://dx.doi.org/10.1155/2017/1594963] [PMID: 28819542]
[http://dx.doi.org/10.1089/jmf.2017.0142] [PMID: 31120370]
[http://dx.doi.org/10.1055/s-0031-1298229] [PMID: 22294264]
[http://dx.doi.org/10.1016/j.bioorg.2018.07.011] [PMID: 30032067]
[http://dx.doi.org/10.1038/srep27156] [PMID: 27257160]
[http://dx.doi.org/10.1248/bpb.b15-00471] [PMID: 26289125]
[http://dx.doi.org/10.1080/10286020.2012.670221] [PMID: 22587800]
[http://dx.doi.org/10.1371/journal.pone.0118188] [PMID: 25706719]
[http://dx.doi.org/10.1016/j.phytochem.2018.10.028] [PMID: 30390605]
[http://dx.doi.org/10.1016/j.fitote.2020.104682] [PMID: 32628985]
[http://dx.doi.org/10.1038/s41401-020-0492-5] [PMID: 32814819]
[http://dx.doi.org/10.1016/j.phytochem.2014.10.015] [PMID: 25457492]
[http://dx.doi.org/10.1080/10286020.2015.1044985] [PMID: 26027676]
[http://dx.doi.org/10.1080/14786419.2019.1667353] [PMID: 31554425]
[http://dx.doi.org/10.1021/jf302639b] [PMID: 22835135]
[http://dx.doi.org/10.3390/molecules24132497] [PMID: 31288489]
[http://dx.doi.org/10.1007/s12272-017-0891-4] [PMID: 28093699]
[http://dx.doi.org/10.1021/acs.orglett.9b03664] [PMID: 31746610]
[http://dx.doi.org/10.1080/14786419.2014.999333] [PMID: 25675363]
[http://dx.doi.org/10.1080/10286020.2012.724400] [PMID: 23088613]
[http://dx.doi.org/10.1016/j.fitote.2012.03.001] [PMID: 22433397]
[http://dx.doi.org/10.1016/j.fitote.2013.10.017] [PMID: 24216050]
[http://dx.doi.org/10.1080/10286020.2014.971775] [PMID: 25401999]
[http://dx.doi.org/10.1016/j.ejmech.2014.11.047] [PMID: 25461329]
[http://dx.doi.org/10.1021/acs.jafc.7b02088] [PMID: 28649844]
[http://dx.doi.org/10.3390/molecules24162893] [PMID: 31395821]
[http://dx.doi.org/10.3746/pnf.2019.24.1.84] [PMID: 31008101]
[http://dx.doi.org/10.1080/14786419.2019.1573236] [PMID: 30822142]
[http://dx.doi.org/10.1016/j.fct.2010.11.045] [PMID: 21130832]
[http://dx.doi.org/10.3390/ijms13022472] [PMID: 22408465]
[http://dx.doi.org/10.1142/S0192415X12500279] [PMID: 22419428]
[http://dx.doi.org/10.1080/14786419.2014.900770] [PMID: 24673367]
[http://dx.doi.org/10.1111/1750-3841.13099] [PMID: 26469191]
[http://dx.doi.org/10.1016/j.foodchem.2014.08.101] [PMID: 25308652]
[http://dx.doi.org/10.3109/13880209.2015.1101476] [PMID: 26510817]
[http://dx.doi.org/10.1016/j.foodchem.2017.03.045] [PMID: 28407916]
[http://dx.doi.org/10.1016/j.lfs.2018.08.060] [PMID: 30170070]
[http://dx.doi.org/10.1016/j.phymed.2018.09.016] [PMID: 30668403]
[http://dx.doi.org/10.3390/molecules24122329] [PMID: 31242560]
[http://dx.doi.org/10.3390/molecules24173082] [PMID: 31450672]
[http://dx.doi.org/10.1016/j.fct.2019.110730] [PMID: 31369850]
[http://dx.doi.org/10.1016/j.foodchem.2019.125739] [PMID: 31787394]
[http://dx.doi.org/10.1080/14786419.2020.1810036] [PMID: 32840147]
[http://dx.doi.org/10.1007/s11130-021-00922-7] [PMID: 34570290]
[http://dx.doi.org/10.3390/foods11091252] [PMID: 35563975]
[http://dx.doi.org/10.3390/antiox12020382] [PMID: 36829941]
[http://dx.doi.org/10.3390/ijms22158120] [PMID: 34360887]
[http://dx.doi.org/10.3390/molecules26247642] [PMID: 34946724]
[http://dx.doi.org/10.1016/j.jep.2021.114483] [PMID: 34339793]
[http://dx.doi.org/10.3390/ijms22073659] [PMID: 33915826]
[http://dx.doi.org/10.1080/14786419.2018.1527832] [PMID: 30470128]
[http://dx.doi.org/10.3390/molecules25061385] [PMID: 32197466]
[http://dx.doi.org/10.1039/C5FO00474H] [PMID: 26294257]
[http://dx.doi.org/10.3390/metabo10010007] [PMID: 31861822]
[http://dx.doi.org/10.1039/D0FO00012D] [PMID: 32196541]
[http://dx.doi.org/10.1016/j.jnutbio.2016.07.004] [PMID: 27580020]
[http://dx.doi.org/10.1080/14786419.2019.1601094] [PMID: 30968706]
[PMID: 30989864]
[http://dx.doi.org/10.1016/j.ijbiomac.2014.09.060] [PMID: 25316427]
[http://dx.doi.org/10.1039/C7FO00417F] [PMID: 28650018]
[http://dx.doi.org/10.1016/j.carbpol.2014.09.052] [PMID: 25498609]
[http://dx.doi.org/10.1021/acs.jafc.8b01357] [PMID: 29969905]
[http://dx.doi.org/10.3390/ijms21186541] [PMID: 32906784]
[http://dx.doi.org/10.1002/ptr.6878] [PMID: 32935429]
[http://dx.doi.org/10.3390/nu12020488] [PMID: 32075054]
[http://dx.doi.org/10.3892/or.2017.5912] [PMID: 28849234]
[http://dx.doi.org/10.3390/ijms19092681]
[http://dx.doi.org/10.1016/j.foodchem.2020.126236] [PMID: 32000079]
[http://dx.doi.org/10.1016/j.phymed.2021.153641] [PMID: 34281775]
[http://dx.doi.org/10.1097/FBP.0000000000000549] [PMID: 32040015]
[http://dx.doi.org/10.1016/j.intimp.2018.01.014] [PMID: 29414639]
[http://dx.doi.org/10.1016/j.ijbiomac.2017.03.083] [PMID: 28322946]
[http://dx.doi.org/10.1016/j.biopha.2019.108675] [PMID: 30780108]
[http://dx.doi.org/10.1016/j.ijbiomac.2013.09.022 ] [PMID: 24076200]