Abstract
Several human diseases are associated with the presence of toxic fibrillar protein deposits. These diseases called protein misfolding disorders, are characterized by the accumulation of misfolded protein aggregates in diverse tissues. Strong evidence indicates that the conversion of a normal soluble protein into a β-sheet-rich oligomeric structure and further fibrillar aggregation are the key events in the disease pathogenesis. Therefore, a promising therapeutic target consists of the prevention and dissolution of misfolded protein aggregates. Peptides designed to specifically bind to the pathogenic protein and block and/or reverse its abnormal conformational change constitute a new class of drugs. This article reviews this approach, describing diverse compounds reported to have this activity.
Keywords: Peptide inhibitors, β-sheet breakers, amyloid, conformational disorders, Alzheimer's disease
Current Pharmaceutical Design
Title: Inhibition of Protein Misfolding and Aggregation by Small Rationally-Designed Peptides
Volume: 12 Issue: 20
Author(s): L. D. Estrada and C. Soto
Affiliation:
Keywords: Peptide inhibitors, β-sheet breakers, amyloid, conformational disorders, Alzheimer's disease
Abstract: Several human diseases are associated with the presence of toxic fibrillar protein deposits. These diseases called protein misfolding disorders, are characterized by the accumulation of misfolded protein aggregates in diverse tissues. Strong evidence indicates that the conversion of a normal soluble protein into a β-sheet-rich oligomeric structure and further fibrillar aggregation are the key events in the disease pathogenesis. Therefore, a promising therapeutic target consists of the prevention and dissolution of misfolded protein aggregates. Peptides designed to specifically bind to the pathogenic protein and block and/or reverse its abnormal conformational change constitute a new class of drugs. This article reviews this approach, describing diverse compounds reported to have this activity.
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Cite this article as:
Estrada D. L. and Soto C., Inhibition of Protein Misfolding and Aggregation by Small Rationally-Designed Peptides, Current Pharmaceutical Design 2006; 12 (20) . https://dx.doi.org/10.2174/138161206777698792
DOI https://dx.doi.org/10.2174/138161206777698792 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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