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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Butadiene Sulfone-catalyzed Monobromination of Arenes with NBS as the Bromination Source: A Simple, Mild, Efficient, and Chemoselective Protocol

Author(s): Amit Sharma, Santosh Rudrawar and Hemant R. Jadhav*

Volume 21, Issue 2, 2024

Published on: 06 October, 2023

Page: [201 - 208] Pages: 8

DOI: 10.2174/1570178620666230914164247

Price: $65

Abstract

In literature, dimethyl sulfoxide (DMSO) catalyzed bromination of arenes and heteroarenes is reported. In this study, simple, mild, and chemoselective N-bromosuccinimide (NBS) mediated monobromination of arenes and heteroarenes using butadiene sulfone as a catalyst is reported.

Butadiene sulfone is a good substitute for DMSO as it is volatile, easy to recover and recycle, and environment- friendly. The method has been demonstrated to give high-yield brominated products for an extensive range of activated and deactivated arenes.

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