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Current Indian Science

Editor-in-Chief

ISSN (Print): 2210-299X
ISSN (Online): 2210-3007

Review Article

Promising Anticancer Stand-ins of Phyllanthus Species

Author(s): Simran, Vani, Priyanka Kriplani* and Kumar Guarve

Volume 1, 2023

Published on: 14 September, 2023

Article ID: e060923220756 Pages: 12

DOI: 10.2174/2210299X01666230906092220

open_access

Abstract

Background: Phyllanthus species plants along with their active constituent phyllanthin, are the most widely used plants to cure various diseases. Present studies indicate their applicability as anti-diabetic, anti-malarial, antiplasmodial, anti-viral, anti-inflammatory, antibacterial, antioxidant, antineoplastic, diuretic, nephroprotective, hypolipidemic, and hepatoprotective properties.

Objective: The objective of the present review is to study the recent literature and patents, including the various methods of extraction and isolation of phyllanthin along with its pharmacokinetics and clinical trials and mainly focussing on their anticancer potential along with a brief on other pharmacological activities.

Methods: Recent prose and patents focussing on the anticancer potential of mainly P. amarus and P. niruri have been highlighted with special emphasis on scientific novelty and impact.

Results: Both P.amarus and P.niruri displayed good anticancer potential in multiple tumors and synergistic effects when combined with other anticancer drugs. Ne isolation/extraction methods, clinical trials, and pharmacokinetic studies have been discussed.

Conclusion: The anticancer potential of P.amarus and P.niruri has opened new avenues for further research. Clinical trials are the need of the hour to validate and confirm the tumor-suppressing properties of both plants.

[1]
Sibiya, A.M.; Ramya, A.K.; Vaseeharan, B. Bioactive molecules from phyllanthus niruri and investigating their effects against diabetes. MedDocs eBooks., 2020, 1-7.
[2]
National herbal medicine is writing the group volumeNational herbal medicine compilation; People's Health Publisher: Beijing, 1978, First Volume, p. 263.
[3]
Li, P.T. A revision of Chinese phyllanthus (Euphorbiaceae). J. Syst. Evol., 1987, 25(5), 371-383.
[4]
Mao, X.; Wu, L.F.; Guo, H.L.; Chen, W.J.; Cui, Y.P.; Qi, Q.; Li, S.; Liang, W.Y.; Yang, G.H.; Shao, Y.Y.; Zhu, D.; She, G.M.; You, Y.; Zhang, L.Z. The genus phyllanthus: An ethnopharmacological, phytochemical, and pharmacological review. Evid. Based Complement. Alternat. Med., 2016, 2016, 1-36.
[http://dx.doi.org/10.1155/2016/7584952] [PMID: 27200104]
[5]
Bagalkotkar, G.; Sagineedu, S.R.; Saad, M.S.; Stanslas, J. Phytochemicals from phyllanthus niruri Linn. and their pharmacological properties: A review. J. Pharm. Pharmacol., 2010, 58(12), 1559-1570.
[http://dx.doi.org/10.1211/jpp.58.12.0001] [PMID: 17331318]
[6]
Basavaraju, M.; Gunashree, B. S.; Bagalkotkar, G. phyllanthus niruri L: A holistic medicinal plant with modern therapeutics; Scientist R Academy, 2022, 1, p. 12.
[7]
Patel, J.R.; Tripathi, P.; Sharma, V.; Chauhan, N.S.; Dixit, V.K. phyllanthus amarus: Ethnomedicinal uses, phytochemistry and pharmacology: A review. J. Ethnopharmacol., 2011, 138(2), 286-313.
[http://dx.doi.org/10.1016/j.jep.2011.09.040] [PMID: 21982793]
[8]
Sharma, A.; Singh, R.T.; Handa, S.S. Estimation of phyllanthin and hypophyllanthin by high performance liquid chromatography inphyllanthus amarus.. Phytochem. Anal., 1993, 4(5), 226-229.
[http://dx.doi.org/10.1002/pca.2800040507]
[9]
Yanyun, C.; Yirao, Z.; Guanghui, K.N. phyllanthus embical fruit tablet and preparation method thereof. CN105166883B, 2019.
[10]
Yadav, N.P.; Pal, A.; Shanker, K.; Bawankule, D.U.; Gupta, A.K.; Darokar, M.P.; S Khanuja, S.P. Synergistic effect of silymarin and standardized extract of phyllanthus amarus against CCl4-induced hepatotoxicity in Rattus norvegicus. Phytomedicine., 2008, 15(12), 1053-1061.
[http://dx.doi.org/10.1016/j.phymed.2008.08.002] [PMID: 18848770]
[11]
Syamasundar, K.V.; Singh, B.; Singh Thakur, R.; Husain, A.; Yoshinobu, K.; Hiroshi, H. Antihepatotoxic principles of phyllanthus niruri herbs. J. Ethnopharmacol., 1985, 14(1), 41-44.
[http://dx.doi.org/10.1016/0378-8741(85)90026-1] [PMID: 4087921]
[12]
Baskaran, M.A.; Periyasamy, L.A.; Rajagopalan, R.U. Effect of phyllanthus niruri on alcohol and polyunsaturated fatty acid induced oxidative stress in Liver. Int. J. Pharm. Pharm. Sci., 2010, 2(4), 58-62.
[13]
Suresh, V.; Sojan, J.; Krishna Radhika, N.; Asha, V.V. Anti-HBV activity of the different extracts from phyllanthus rheedei wight in cell culture based assay systems. J. Ethnopharmacol., 2014, 156, 309-315.
[http://dx.doi.org/10.1016/j.jep.2014.08.028] [PMID: 25219604]
[14]
Krithika, R.; Jyothilakshmi, V.; Verma, R.J. Phyllanthin inhibits CCl 4 -mediated oxidative stress and hepatic fibrosis by down-regulating TNF-α/NF-κB, and pro-fibrotic factor TGF-β1 mediating inflammatory signaling. Toxicol. Ind. Health., 2016, 32(5), 953-960.
[http://dx.doi.org/10.1177/0748233714532996] [PMID: 24817434]
[15]
Pradit, W.; Chomdej, S.; Nganvongpanit, K.; Ongchai, S. Chondroprotective potential of phyllanthus amarus Schum. & Thonn. in experimentally induced cartilage degradation in the explants culture model. In Vitro Cell. Dev. Biol. Anim., 2015, 51(4), 336-344.
[http://dx.doi.org/10.1007/s11626-014-9846-y] [PMID: 25515248]
[16]
Ilangkovan, M.; Jantan, I.; Bukhari, S.N.A. Phyllanthin from phyllanthus amarus inhibits cellular and humoral immune responses in Balb/C mice. Phytomedicine., 2016, 23(12), 1441-1450.
[http://dx.doi.org/10.1016/j.phymed.2016.08.002] [PMID: 27765364]
[17]
Murugaiyah, V.; Chan, K.L. Mechanisms of antihyperuricemic effect of phyllanthus niruri and its lignan constituents. J. Ethnopharmacol., 2009, 124(2), 233-239.
[http://dx.doi.org/10.1016/j.jep.2009.04.026] [PMID: 19397979]
[18]
Gowrishanker, B.; Vivekanandan, O.S. In vivo studies of a crude extract of phyllanthus amarus L. in modifying the genotoxicity induced in Vicia faba L. by tannery effluents. Mutat Res., 1994, 322(3), 185-192.
[http://dx.doi.org/10.1016/0165-1218(94)90005-1] [PMID: 7521518]
[19]
Meselhy, M.R.; Abdel-Sattar, O.E.; El-Mekkawy, S.; EL-Desoky, A.M.; Mohamed, S.O.; Mohsen, S.M.; Abdel-Sattar, E.; El-Halawany, A. Preparation of Lignan-Rich Extract from the Aerial Parts of phyllanthus niruri Using Nonconventional Methods. Molecules., 2020, 25(5), 1179.
[http://dx.doi.org/10.3390/molecules25051179] [PMID: 32151037]
[20]
Murugaiyah, V.; Chan, K.L. Determination of four lignans in phyllanthus niruri L. by a simple high-performance liquid chromatography method with fluorescence detection. J. Chromatogr. A, 2007, 1154(1-2), 198-204.
[http://dx.doi.org/10.1016/j.chroma.2007.03.079] [PMID: 17418855]
[21]
Thakur, I.; Bigoniya, P. Radioprotective and free radicals scavenging activity of phyllanthin: Isolated from phyllanthus niruri.. Int. J. Pharm. Biol. Sci., 2014, 4, 1-10.
[22]
Row, L.R.; Srinivasulu, C.; Smith, M.; Rao, G.S.R.S. Crystalline constituents of euphorbiaceae—V. Tetrahedron., 1966, 22(8), 2899-2908.
[http://dx.doi.org/10.1016/S0040-4020(01)99083-0]
[23]
Liquon, R. Method for separating and purifying phyllanthin from common leaf flower herb. CN101898940A, 2010.
[24]
Zhenguo, Z.; Xuejian, L.; Mingjiao, D. Phyllanthus emblica leaf or fruit anticancer Chinese medicine and preparation method and use thereof. CN101391961A, 2009.
[25]
Tang, Y.Q.; Jaganath, I.B.; Sekaran, S.D. phyllanthus spp. induces selective growth inhibition of PC-3 and MeWo human cancer cells through modulation of cell cycle and induction of apoptosis. PLoS One., 2010, 5(9), e12644.
[http://dx.doi.org/10.1371/journal.pone.0012644] [PMID: 20838625]
[26]
de Araújo Júnior, R.F.; de Souza, T.P.; Pires, J.G.L.; Soares, L.A.L.; de Araújo, A.A.; Petrovick, P.R.; Mâcedo, H.D.O.; de Sá Leitão Oliveira, A.L.C.; Guerra, G.C.B. A dry extract of phyllanthus niruri protects normal cells and induces apoptosis in human liver carcinoma cells. Exp. Biol. Med., 2012, 237(11), 1281-1288.
[http://dx.doi.org/10.1258/ebm.2012.012130] [PMID: 23239439]
[27]
Tang, Y.Q.; Jaganath, I.; Manikam, R.; Sekaran, S.D. Phyllanthus Suppresses Prostate Cancer Cell, PC-3, Proliferation and Induces Apoptosis through Multiple Signalling Pathways (MAPKs, PI3K/Akt, NFκB, and Hypoxia). Evid. Based Complement. Alternat. Med., 2013, 2013, 1-13.
[http://dx.doi.org/10.1155/2013/609581] [PMID: 23690850]
[28]
Tang, Y.Q.; Jaganath, I.B.; Manikam, R.; Sekaran, S.D. Inhibition of MAPKs, Myc/Max, NFκB, and hypoxia pathways by phyllanthus prevents proliferation, metastasis and angiogenesis in human melanoma (MeWo) cancer cell line. Int. J. Med. Sci., 2014, 11(6), 564-577.
[http://dx.doi.org/10.7150/ijms.7704] [PMID: 24782645]
[29]
Lee, S.H.; Jaganath, I.B.; Atiya, N.; Manikam, R.; Sekaran, S.D. Suppression of ERK1/2 and hypoxia pathways by four phyllanthus species inhibits metastasis of human breast cancer cells. J. Food Drug. Anal., 2016, 24(4), 855-865.
[http://dx.doi.org/10.1016/j.jfda.2016.03.010] [PMID: 28911625]
[30]
Jose, J.; Sudhakaran, S.; Kumar, S.; Jayaraman, S.; Variyar, E.J. A comparative evaluation of anticancer activities of flavonoids isolated from mimosa pudica, aloe vera and phyllanthus niruri against human breast carcinoma cell line (Mcf-7) using mtt assay. Int. J. Pharm. Pharm. Sci., 2014, 6(2), 319-322.
[31]
Hermansyah, D.; Putra, A.; Munir, D.; Lelo, A.; Amalina, N.D.; Alif, I. Synergistic effect of Curcuma longa extract in combination with Phyllanthus niruri extract in regulating Annexin A2, epidermal growth factor receptor, matrix metalloproteinases, and pyruvate kinase M1/2 signaling pathway on breast cancer stem cell. Open Access Maced. J. Med. Sci., 2021, 9(A), 271-285.
[32]
Parvathaneni, M.; Battu, G.R.; Gray, A.I.; Gummalla, P. Investigation of anticancer potential of hypophyllanthin and phyllanthin against breast cancer by in vitro and in vivo methods. Asian Pac. J. Trop. Dis., 2014, 4, S71-S76.
[http://dx.doi.org/10.1016/S2222-1808(14)60417-5]
[33]
Guo, J.; Jiang, Z.; Liu, B; Wang, C; Zhang, W. Synergistic combination of a Phyllanthus amarus extract and 5-fluorouracil for treatment of subjects with cancer. AU2016101447A4, 2016.
[34]
Deliang, L.; Pingkang, G.; Artemisia, C.; Zhong, C.; Hui, Y.H. Application of traditional Chinese medicine composition containing Phyllanthus urinaria, corious versicolor, salvia miltiorrhiza and lithospermum in preparation of medicine for inhibiting postoperative recurrence of liver cancer. CN114699441A, 2022.
[35]
Chunquan, L; Yicun, C; Chaosheng, C; Xiuying, C Preparation method and application of Phyllanthus emblica L. polysaccharide. CN104262504A, 2016.
[36]
Mohamed, S.I.A.; Jantan, I.; Nafiah, M.A.; Seyed, M.A.; Chan, K.M. Lignans and polyphenols of phyllanthus amarus schumach and thonn induce apoptosis in hct116 human colon cancer cells through caspases-dependent pathway. Curr. Pharm. Biotechnol., 2021, 22(2), 262-273.
[http://dx.doi.org/10.2174/1389201021666200612173029] [PMID: 32532192]
[37]
Raphael, K.R.; Kuttan, R. Inhibition of experimental gastric lesion and inflammation by phyllanthus amarus extract. J. Ethnopharmacol., 2003, 87(2-3), 193-197.
[http://dx.doi.org/10.1016/S0378-8741(03)00120-X] [PMID: 12860307]
[38]
Júnior, R.F.A.; Soares, L.A.; da Costa Porto, C.R.; de Aquino, R.G.; Guedes, H.G.; Petrovick, P.R.; de Souza, T.P.; Araújo, A.A.; Guerra, G.C. Growth inhibitory effects of phyllanthus niruri extracts in combination with cisplatin on cancer cell lines. World J. Gastroenterol., 2012, 18(31), 4162-6168.
[http://dx.doi.org/10.3748/wjg.v18.i31.4162] [PMID: 22919249]
[39]
Sayuti, M.; Riwanto, I.; Boediono, B.P.; Akbar, T.I. Anticancer Activity of phyllanthus niruri Linn Extract in Colorectal Cancer Patients: A phase II Clinical Trial. Studies, 2020, 10, 17.
[40]
Puspita, N.A.; Alhebshi, H. The effect of phyllanthus niruri L extracts on human leukemic cell proliferation and apoptosis induction. Indones. J. Pharm., 2019, 30(4), 241.
[http://dx.doi.org/10.14499/indonesianjpharm30iss4pp241]
[41]
Sharma, P.; Parmar, J.; Verma, P.; Sharma, P.; Goyal, P.K. Anti-tumor activity of phyllanthus niruri (a medicinal plant) on chemical-induced skin carcinogenesis in mice. Asian Pac. J. Cancer Prev., 2009, 10(6), 1089-1094.
[PMID: 20192590]
[42]
Unni, R.; Shah, G.; Snima, K.S.; Kamath, C.R.; Nair, S.; Lakshmanan, V.K. Enhanced delivery of phyllanthus niruri nanoparticles for prostate cancer therapy. J. of Bionanoscience., 2014, 8(2), 101-107.
[http://dx.doi.org/10.1166/jbns.2014.1204]
[43]
Kalidindi, S.R. Phyllanthus emblica and shilajit have synergistic benefits when used with chromium-containing compositions to improve endothelial function and cardiovascular health. US10183047B2, 2019.
[44]
Ying, F; Zhang, S.G; Chen, H.; Zhang, X.; Zheng, W.; Jin, H.G; Hou, L.K; Min, B.Z. Phyllanthus emblica fruit wine preparation method and Phyllanthus emblica fruit wine prepared through method. CN105462743A, 2014.
[45]
Kaur, S.; Mahmood, K.; Southall, M.D. Extracts of Phyllanthus niruri. US8075931B2, 2011.
[46]
Ott Manns, MP Inventor. use of phyllanthus constituents for treating or preventing infections caused by hepatitis b viruses. US7829124B2, 2010.
[47]
Van, N; Kiang, H.T. Fructose Phyllanthus emblica juice and production method there of. CN103519263A, 2014.
[48]
Li, X.Y.; Huang, M.; Shi, S.; Min, W.Z.; Yi, Z.; Yi, D. A kind of Phyllanthus emblica Nectar wine and preparation method thereof. CN103484293B, 2016.
[49]
Changan, P.; Weihua, W. Production method of Phyllanthus emblica and Athyrium multidentatum fruit-vegetable chewable tablets. CN106036617A, 2016.
[50]
Yang, C.G.; Changyi, P.Y.; Chuanhai, S. Low sugar beverage of Phyllanthus emblica and preparation method thereof. CN108925794A, 2018.
[51]
Dongliang, Y.Y.L.; Zongze, G. Phyllanthus emblica targeted refined substance, preparation method and application thereof in cigarettes. CN111772227B, 2022.
[52]
Lingxiao, W.; Bitao, W. kind of preparation method of Phyllanthus embical fruit sprouted unpolished rice vegetable protein dew. CN109363022A, 2019.
[53]
Wu, L.Y.; Zhengping, S.L.; Wang, L.J.; Liang, F.L.; Wenting, W. Method for preparing nano-silver composite particles from Phyllanthus emblica polysaccharide. CN107309438B, 2021.
[54]
Jun, Z. Phyllanthus emblica-containing pearl-shaped ball and processing method thereof. CN103393044A, 2013.
[55]
Kalidindi, S R Phyllanthus emblica compositions for reduction of blood glucose levels. WO2015191206A1, 2015.
[56]
Liguo, Z.; Jiaping, Z. 2014.
[57]
Cui Taomei Double Happiness Su Mei Zhou Lin Cha Yufeng Yang and Kim Li Xueqin Wang Dayuan Gao Ying. preparation method of phyllanthus emblica extract for removing freckles and whitening skin. CN108186456B, 2020.
[58]
Minghao, Z.; Jindan, Z.; Ruffa, Z. Quality control method and application of Phyllanthus urinaria capsules. CN113447598A, 2021.
[59]
Keudell, C.V.; Giessen, R.V. Use of phyllanthus component for the treatment or prophylaxis of infections triggered by flaviviridae. US20040028754A1, 2004.
[60]
Keudell, C.V. Compositions comprising Phyllanthus extract for use in the treatment or prevention of a sars-cov-2 infection and/or at least one symptom of covid-19. EP3954379A1, 2022.
[61]
Nishiura, J.L.; Campos, A.H.; Boim, M.A.; Heilberg, I.P.; Schor, N. phyllanthus niruri normalizes elevated urinary calcium levels in calcium stone forming (CSF) patients. Urol. Res., 2004, 32(5), 362-366.
[http://dx.doi.org/10.1007/s00240-004-0432-8] [PMID: 15221244]
[62]
Sarisetyaningtyas, P.V.; Hadinegoro, S.R.; Munasir, Z. Randomized controlled trial of phyllanthus niruri linn extract. Paediatr. Indones., 2016, 46(2), 77-81.
[http://dx.doi.org/10.14238/pi46.2.2006.77-81]
[63]
Dirjomuljono, M.; Kristyono, I.; Tjandrawinata, R.R.; Nofiarny, D. Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and phyllanthus niruri extract. Int. J. Clin. Pharmacol. Ther., 2008, 46(6), 295-306.
[http://dx.doi.org/10.5414/CPP46295] [PMID: 18541126]
[64]
Schuler, T.D.; Shahani, R.; Honey, R.J.D.A.; Pace, K.T. Medical expulsive therapy as an adjunct to improve shockwave lithotripsy outcomes: A systematic review and meta-analysis. J. Endourol., 2009, 23(3), 387-393.
[http://dx.doi.org/10.1089/end.2008.0216] [PMID: 19245302]
[65]
Boim, M.A.; Heilberg, I.P.; Schor, N. phyllanthus niruri as a promising alternative treatment for nephrolithiasis. Int. Braz J Urol, 2010, 36(6), 657-664.
[http://dx.doi.org/10.1590/S1677-55382010000600002] [PMID: 21176271]
[66]
Colpo, E.; Vilanova, C.D.D.A.; Pereira, R.P.; Reetz, L.G.B.; Oliveira, L.; Farias, I.L.G.; Boligon, A.A.; Athayde, M.L.; Rocha, J.B.T. Antioxidant effects of phyllanthus niruri tea on healthy subjects. Asian Pac. J. Trop. Med., 2014, 7(2), 113-118.
[http://dx.doi.org/10.1016/S1995-7645(14)60005-5] [PMID: 24461523]
[67]
Shanmugam, K.; Shanmugam, B.; Ravi, S.; Subbaiah, G.; Ramakrishana, C.; Mallikarjuna, K.; Reddy, K. Exploratory studies of (-)-Epicatechin, a bioactive compound of phyllanthus niruri, on the antioxidant enzymes and oxidative stress markers in D-galactosamine-induced hepatitis in rats: A study with reference to clinical prospective. Pharmacogn. Mag., 2017, 13(49)(Suppl. 1), 56.
[http://dx.doi.org/10.4103/0973-1296.203973] [PMID: 28479727]
[68]
Pucci, N.D.; Marchini, G.S.; Mazzucchi, E.; Reis, S.T.; Srougi, M.; Evazian, D.; Nahas, W.C. Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: A perspective for disease prevention. Int. Braz J. Urol., 2018, 44(4), 758-764.
[http://dx.doi.org/10.1590/s1677-5538.ibju.2017.0521] [PMID: 29617079]
[69]
Baiguera, C.; Boschetti, A.; Raffetti, E.; Zanini, B.; Puoti, M.; Donato, F. <b><i>phyllanthus niruri</i></b> versus Placebo for Chronic Hepatitis B Virus Infection: A Randomized Controlled Trial. Complement. Med. Res., 2018, 25(6), 376-382.
[http://dx.doi.org/10.1159/000484927] [PMID: 30372693]
[70]
Girish, C.; Sowjanya, K.; Bammigatti, C.; Prasanna Lakshmi, N. Efficacy of phyllanthus niruri on improving liver functions in patients with alcoholic hepatitis: A double-blind randomized controlled trial. Indian J. Pharmacol., 2021, 53(6), 448-456.
[http://dx.doi.org/10.4103/ijp.IJP_540_20] [PMID: 34975132]
[71]
Decha, P.; Kanokwan, K.; Khanittha, W.; Pisittawoot, A. Phonophoresis of phyllanthus amarus nanoparticle gel improves functional capacity in individuals with knee osteoarthritis: A randomized controlled trial. 2020, 24(1), 15-18.
[72]
George, A.; Udani, J.K.; Yusof, A. Effects of phyllanthus amarus PHYLLPRO TM leaves on hangover symptoms: A randomized, double-blind, placebo-controlled crossover study. Pharm. Biol., 2019, 57(1), 145-153.
[http://dx.doi.org/10.1080/13880209.2019.1585460] [PMID: 30922154]
[73]
Hanh, N.D.; Sinchaipanid, N.; Mitrevej, A. Physicochemical characterization of phyllanthin from phyllanthus amarus Schum. et Thonn. Drug Dev. Ind. Pharm., 2014, 40(6), 793-802.
[http://dx.doi.org/10.3109/03639045.2013.788010] [PMID: 23594304]
[74]
Parvathaneni, M.; Rao Battu, G.; Jangiti, R.; Diyya, K. Pharmacokinetic study of phyllanthin and hypophyllanthin after oral administration to rats. Pharmacogn. J., 2014, 6(2), 45-51.
[http://dx.doi.org/10.5530/pj.2014.2.8]
[75]
Sethiya, N.K.; Shah, P.; Rajpara, A.; Nagar, P.A.; Mishra, S.H. Antioxidant and hepatoprotective effects of mixed micellar lipid formulation of phyllanthin and piperine in carbon tetrachloride-induced liver injury in rodents. Food Funct., 2015, 6(11), 3593-3603.
[http://dx.doi.org/10.1039/C5FO00947B] [PMID: 26333006]

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      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('316409794','',1,1740457185,1740457185) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740457185
      2.12msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('316409794','/article/134300',1,1740457185,1740457185)
      260μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 316409794 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316409794) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 316409794 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316409794) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 316409794 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316409794) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 316409794 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316409794) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 316409794 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316409794) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 316409794 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316409794) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 316409794 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316409794) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 316409794 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316409794) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 316409794 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316409794) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 316409794 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316409794) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 316409794 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316409794) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 316409794 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316409794) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 316409794 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316409794) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 316409794 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316409794) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 316409794 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316409794) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 316409794 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316409794) limit 1
      17.52msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 316409794
      • 1: 316409794
      • 2: 316409794
      • 3: 316409794
      • 4: 316409794
      • 5: 316409794
      • 6: 316409794
      • 7: 316409794
      • 8: 316409794
      • 9: 316409794
      • 10: 316409794
      • 11: 316409794
      • 12: 316409794
      • 13: 316409794
      • 14: 316409794
      • 15: 316409794
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=134300
      920μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 213 limit 1
      400μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 213
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=213) and sj.journal_id!=213 group by `j`.`nid`) as `aggregate_table`
      670μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=213) and sj.journal_id!=213 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      590μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=213) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      1.41msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=213) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      1.28msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '134300'
      230μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 134300
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '134300'
      2.42msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 134300
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '134300' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      2.71msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 134300
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      260μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      490μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 213 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      28.71msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 213 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      3.08msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 213 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      1msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 134300 limit 1
      210μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 134300
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 134300 and content_type = 'article' order by status desc limit 1
      270μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 220756 limit 1
      210μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 220756
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      250μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CIS' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      820μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CIS
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '134300' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      370μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '12232' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      340μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3282' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      350μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '1' and is_uploaded = 1 and issue_id = 12232 order by cast(first_page as SIGNED) desc limit 1
      720μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 1
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '12' and is_uploaded = 1 and issue_id = 12232 order by cast(first_page as SIGNED) asc limit 1
      750μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 12
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      200μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      220μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 134300 limit 1
      2.42msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 134300
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 213 and `b`.`banner_from_date` <= 1740457185 and `b`.`banner_to_date` >= 1740457185 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.15msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 213
      • 3: 1740457185
      • 4: 1740457185
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 213 and `b`.`banner_from_date` <= 1740457185 and `b`.`banner_to_date` >= 1740457185 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.13msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 213
      • 3: 1740457185
      • 4: 1740457185
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='08851ca843d755a8fbccea9000832ead'
      260μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
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        ClearShow all
        Date ↕MethodURLData
        #12025-02-25 04:19:45GET/article/134300514331