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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Review Article

Emergence of Monkeypox (MPX): A Close Relative of Small Pox During COVID-19 Era

Author(s): Ivneet Kour*, Lipika Singhal, Sonia Mehta and Varsha Gupta

Volume 24, Issue 1, 2024

Published on: 07 September, 2023

Article ID: e230823220244 Pages: 7

DOI: 10.2174/1871526523666230823105945

Price: $65

Abstract

After the eradication of smallpox (SPX), a new zoonotic threat that can trigger outbreaks has emerged. It may be fatal during the COVID19 outbreak. Humanity continues to be threatened due to re-emergence of the outbreaks. In most cases, new emerging viral agents originate from nonhuman hosts with zoonotic origins. Recent outbreaks of zoonotic infectious diseases with the potential to cause epidemics and pandemics continue to pose a major threat to the health security of entire regions, continents, and the world at large. Around five decades backthat Monkeypox (MPX) was reported for the first time in the Democratic Republic of the Congo (DRC) and was then confined to Central Africa only. Over the time, it has spread to other regions of Africa as well as outside Africa. As of August 2022, 40398 infections have been confirmed in almost 68 countries that have never reported MPX before. The majority of infections have been reported in Europe and Southeast Asia. On 23rd August 2022, MPX was declared a public health emergency of international concern, a step below declaring any disease as a pandemic. The article discusses the recent history of MPX outbreaks, as well as the evolving clinical manifestations of the disease, and the possible causes of the increase in cases, including the cessation of SPX vaccinations.

Graphical Abstract

[1]
Chauhan V, Thakur S, Kelkar D, et al. Why should RNA viruses have all the fun - Monkeypox, a close relative of smallpox and a DNA virus. J Glob Infect Dis 2022; 14(2): 47-9.
[http://dx.doi.org/10.4103/jgid.jgid_104_22] [PMID: 35910829]
[2]
Woolhouse MJ, Adair K, Brierley L. RNA viruses: A case study of the biology of emerging infectious diseases. Microbiol Spectr 2013; 1(1)
[3]
Mourya D, Yadav P, Ullas PT, et al. Emerging/re-emerging viral diseases & new viruses on the Indian horizon. Indian J Med Res 2019; 149(4): 447-67.
[http://dx.doi.org/10.4103/ijmr.IJMR_1239_18] [PMID: 31411169]
[4]
Sklenovská N, Van Ranst M. Emergence of monkeypox as the most important orthopoxvirus infection in humans. Front Public Health 2018; 6: 241.
[http://dx.doi.org/10.3389/fpubh.2018.00241] [PMID: 30234087]
[5]
Woolhouse MEJ, Brierley L, McCaffery C, Lycett S. Assessing the epidemic potential of RNA and DNA Viruses. Emerg Infect Dis 2016; 22(12): 2037-44.
[http://dx.doi.org/10.3201/eid2212.160123] [PMID: 27869592]
[6]
Ejaz H, Junaid K, Younas S, et al. Emergence and dissemination of monkeypox, an intimidating global public health problem. J Infect Public Health 2022; 15(10): 1156-65.
[http://dx.doi.org/10.1016/j.jiph.2022.09.008] [PMID: 36174285]
[7]
Shafaati M, Zandi M. Human monkeypox (hMPXV) re‐emergence: Host immunity status and current vaccines landscape. J Med Virol 2023; 95(1): e28251.
[http://dx.doi.org/10.1002/jmv.28251] [PMID: 36271768]
[8]
Riedel S. Smallpox and biological warfare: A disease revisited. Proc Bayl Univ Med Cent 2005; 18(1): 13-20.
[9]
Singhal L, Kour I, Gupta V. Diagnostic Stewardship in Times of COVID-19 Pandemic. Infect Disord Drug Targets 2022; 22(5): e270122200587.
[http://dx.doi.org/10.2174/1871526522666220127115718] [PMID: 35086460]
[10]
Commemorating Smallpox Eradication. A legacy of hope, for COVID-19 and other diseases. 2022. Available from: https://www.who.int/news/item/08-05-2020-commemorating-smallpox-eradication-a-legacy-of (cited 13 July 2022)
[11]
Ligon BL. Monkeypox: A review of the history and emergence in the Western hemisphere. Semin Pediatr Infect Dis 2004; 15(4): 280-7.
[http://dx.doi.org/10.1053/j.spid.2004.09.001] [PMID: 15494953]
[12]
Colavita F, Antinori A, Nicastri E, Focosi D, Girardi E, Vaia F, et al. Monkeypox virus in human body sites and fluids: evidence for transmission. Lancet Infect Dis 2022; 23(1): 6-8.
[PMID: 36183708]
[13]
Ladnyj ID, Ziegler P, Kima E. A human infection caused by monkeypox virus in basankusu territory, democratic republic of the congo. Bull World Health Organ 1972; 46(5): 593-7.
[PMID: 4340218]
[14]
Reynolds MG, Doty JB, McCollum AM, Olson VA, Nakazawa Y. Monkeypox re-emergence in Africa: A call to expand the concept and practice of One Health. Expert Rev Anti Infect Ther 2019; 17(2): 129-39.
[http://dx.doi.org/10.1080/14787210.2019.1567330] [PMID: 30625020]
[15]
Monkeypox: Experts give virus variants new names. 2022. Available from: https://www.who.int/news/item/12-08-2022-monkeypox--experts-give-virus-variants-new-names (cited 16 August 2022).
[16]
Monkeypox. . 2022. Available from: https://www.who.int/news-room/fact-sheets/detail/monkeypox
[17]
Kozlov M. Monkeypox in Africa: the science the world ignored. Nature 2022; 607(7917): 17-8.
[http://dx.doi.org/10.1038/d41586-022-01686-z] [PMID: 35739391]
[18]
Bunge EM, Hoet B, Chen L, et al. The changing epidemiology of human monkeypox-A potential threat? A systematic review. PLoS Negl Trop Dis 2022; 16(2): e0010141.
[http://dx.doi.org/10.1371/journal.pntd.0010141] [PMID: 35148313]
[19]
Nigeria Centre for Disease Control Nigeria monkeypox monthly situation report. 2019. Available from: [https://reliefweb.int/sites/reliefweb.int/files/resources/5a1a9820f21136842ba43f186b8d09e7.pdf
[20]
Shanmugaraj B, Phoolcharoen W, Khorattanakulchai N. Emergence of monkeypox: Another concern amidst COVID-19 crisis. Asian Pac J Trop Med 2022; 15(5): 193-5.
[http://dx.doi.org/10.4103/1995-7645.346081]
[21]
Fenner F, Henderson DA, Arita I, Jezek Z, Ladnyi ID. Smallpox and its eradication. Geneva: World Health Organization 1988.
[22]
Schneider WH. Smallpox in Africa during colonial rule. Med Hist 2009; 53(2): 193-227.
[http://dx.doi.org/10.1017/S002572730000363X] [PMID: 19367346]
[23]
Doty J, Malekani J, Kalemba L, et al. Assessing monkeypox virus prevalence in small mammals at the human-animal interface in the democratic republic of the Congo. Viruses 2017; 9(10): 283.
[http://dx.doi.org/10.3390/v9100283] [PMID: 28972544]
[24]
Concern grows that human monkeypox outbreak will establish virus in animals outside Africa. 2022. Available from: https://www.science.org/content/article/concern-grows-human-monkeypox-outbreak-willestablish-well (cited 10 October 2022).
[25]
Centers for Disease Control and Prevention. Preliminary report: Multistate outbreak of monkeypox in persons exposed to pet prairie dogs. Available from: http://www.cdc.gov/ncidod/monkeypox/report060903.htm
[26]
The Lancet Regional Health - Europe. Lessons from COVID-19 are shaping the response to monkeypox outbreak. Lancet Reg Health Eur 2022; 18: 100463.
[http://dx.doi.org/10.1016/j.lanepe.2022.100463] [PMID: 35791347]
[27]
Multi-country monkeypox outbreak: situation update. 2022. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON396 (cited 10 October 2022).
[28]
Philip S. 35-yr-old from Kerala is India’s first monkeypox case; Centre sends team. The Indian Express 2022; p. 3.
[29]
Yadav PD, Reghukumar A, Sahay RR, et al. First two cases of Monkeypox virus infection in travellers returned from UAE to India, July 2022. J Infect 2022; 85(5): e145-8.
[http://dx.doi.org/10.1016/j.jinf.2022.08.007]
[30]
Haller SL, Peng C, McFadden G, Rothenburg S. Poxviruses and the evolution of host range and virulence. Infect Genet Evol 2014; 21: 15-40.
[http://dx.doi.org/10.1016/j.meegid.2013.10.014] [PMID: 24161410]
[31]
Hutson CL, Olson VA, Carroll DS, et al. A prairie dog animal model of systemic orthopoxvirus disease using West African and Congo Basin strains of monkeypox virus. J Gen Virol 2009; 90(2): 323-33.
[http://dx.doi.org/10.1099/vir.0.005108-0] [PMID: 19141441]
[32]
Alakunle EF, Okeke MI. Monkeypox virus: A neglected zoonotic pathogen spreads globally. Nat Rev Microbiol 2022; 20(9): 507-8.
[http://dx.doi.org/10.1038/s41579-022-00776-z] [PMID: 35859005]
[33]
Iñigo Martínez J, Gil Montalbán E, Jiménez Bueno S, et al. Monkeypox outbreak predominantly affecting men who have sex with men, Madrid, Spain, 26 April to 16 June 2022. Euro Surveill 2022; 27(27): 2200471.
[http://dx.doi.org/10.2807/1560-7917.ES.2022.27.27.2200471] [PMID: 35801519]
[34]
Word Health Organization (WHO). Disease Outbreak News Available from: https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON393 (accessed on 15 June 2022).
[35]
Ribeiro S, Martins JV, Casaca P, Leite PP, Tavares M, Mansinho K, et al. Ongoing monkeypox virus outbreak, portugal, 29 april to 23 may 2022. euro surveillance: Bulletin europeen sur les maladies transmissibleeuropean. Commun Dis Bull 2022; 27(22)
[36]
MikeS.If monkeypox spreads through sexual contact, is it an STD? Los Angeles Times 2022. ;7.
[37]
Multi-country outbreak of monkeypox, External situation report #3 - 10 August 2022. 2022. Available from: www.who.int/publications/m/item/multi-country-outbreak-of-monkeypox-external (cited 16 August 2022).
[38]
Wang Y, Leng P. Global transmission of Monkeypox virus—a potential threat under the COVID-19 pandemic. Front Immunol 2023; 14: 1174223.
[http://dx.doi.org/10.3389/fimmu.2023.1174223]
[39]
Lum FM, Torres-Ruesta A, Tay MZ, et al. Monkeypox: Disease epidemiology, host immunity and clinical interventions. Nat Rev Immunol 2022; 22(10): 597-613.
[http://dx.doi.org/10.1038/s41577-022-00775-4] [PMID: 36064780]
[40]
McCollum AM, Damon IK. Human monkeypox. Clin Infect Dis 2014; 58(2): 260-7.
[http://dx.doi.org/10.1093/cid/cit703] [PMID: 24158414]
[41]
Vivancos R, Anderson C, Blomquist P, et al. Community transmission of monkeypox in the United Kingdom, April to May 2022. Euro Surveill 2022; 27(22): 2200422.
[http://dx.doi.org/10.2807/1560-7917.ES.2022.27.22.2200422] [PMID: 35656834]
[42]
Guarner J, Johnson BJ, Paddock CD, et al. Monkeypox transmission and pathogenesis in prairie dogs. Emerg Infect Dis 2004; 10(3): 426-31.
[http://dx.doi.org/10.3201/eid1003.030878] [PMID: 15109408]
[43]
Bras G. Observations on the formation of smallpox scars. AMA Arch Pathol 1952; 54(2): 149-56.
[PMID: 14943347]
[44]
Jezek Z, Szczeniowski M, Paluku KM, Mutombo M. Human monkeypox: Clinical features of 282 patients. J Infect Dis 1987; 156(2): 293-8.
[http://dx.doi.org/10.1093/infdis/156.2.293] [PMID: 3036967]
[45]
Likos AM, Sammons SA, Olson VA, et al. A tale of two clades: Monkeypox viruses. J Gen Virol 2005; 86(10): 2661-72.
[http://dx.doi.org/10.1099/vir.0.81215-0] [PMID: 16186219]
[46]
Simpson K, Heymann D, Brown CS, et al. Human monkeypox - After 40 years, an unintended consequence of smallpox eradication. Vaccine 2020; 38(33): 5077-81.
[http://dx.doi.org/10.1016/j.vaccine.2020.04.062] [PMID: 32417140]
[47]
Moss B. Smallpox vaccines: Targets of protective immunity. Immunol Rev 2011; 239(1): 8-26.
[http://dx.doi.org/10.1111/j.1600-065X.2010.00975.x] [PMID: 21198662]
[48]
Spicknall IH, Pollock ED, Clay PA, et al. Modeling the impact of sexual networks in the transmission of monkeypox virus among gay, bisexual, and other men who have sex with men — united states, 2022. MMWR Morb Mortal Wkly Rep 2022; 71(35): 1131-5.
[http://dx.doi.org/10.15585/mmwr.mm7135e2] [PMID: 36048619]
[49]
Cursino M. Monkeypox: First deaths outside Africa in Brazil and Spain. BBC 2022.
[50]
World Health Organization. Vaccines and Immunization for Monkeypox: Interim Guidance.
[51]
von Krempelhuber A, Vollmar J, Pokorny R, et al. A randomized, double-blind, dose-finding Phase II study to evaluate immunogenicity and safety of the third generation smallpox vaccine candidate IMVAMUNE®. Vaccine 2010; 28(5): 1209-16.
[http://dx.doi.org/10.1016/j.vaccine.2009.11.030] [PMID: 19944151]
[52]
Rao AK, Petersen BW, Whitehill F, et al. Use of jynneos (smallpox and monkeypox vaccine, live, nonreplicating) for preexposure vaccination of persons at risk for occupational exposure to orthopoxviruses: Recommendations of the advisory committee on immunization practices — united states, 2022. MMWR Morb Mortal Wkly Rep 2022; 71(22): 734-42.
[http://dx.doi.org/10.15585/mmwr.mm7122e1] [PMID: 35653347]
[53]
Jackson LA, Frey SE, El Sahly HM, et al. Safety and immunogenicity of a modified vaccinia Ankara vaccine using three immunization schedules and two modes of delivery: A randomized clinical non-inferiority trial. Vaccine 2017; 35(13): 1675-82.
[http://dx.doi.org/10.1016/j.vaccine.2017.02.032] [PMID: 28256358]
[54]
Nishiyama Y, Fujii T, Kanatani Y, Shinmura Y, Yokote H, Hashizume S. Freeze-dried live attenuated smallpox vaccine prepared in cell culture “LC16-KAKETSUKEN”: Post-marketing surveillance study on safety and efficacy compliant with Good Clinical Practice. Vaccine 2015; 33(45): 6120-7.
[http://dx.doi.org/10.1016/j.vaccine.2015.09.067] [PMID: 26455406]
[55]
Petersen BW, Harms TJ, Reynolds MG, Harrison LH. Use of vaccinia virus smallpox vaccine in laboratory and health care personnel at risk for occupational exposure to orthopoxviruses-recommendations of the Advisory Committee on Immunization Practices (ACIP), 2015. MMWR Morb Mortal Wkly Rep 2016; 65(10): 257-62.
[http://dx.doi.org/10.15585/mmwr.mm6510a2] [PMID: 26985679]
[56]
Interim Clinical Considerations for Use of JYNNEOS and ACAM2000 Vaccines during the 2022 U.S. Mpox Outbreak. 2022. Available from: https://www.cdc.gov/poxvirus/monkeypox/considerations-for-monkeypox-vaccination.html
[57]
Grosenbach DW, Honeychurch K, Rose EA, et al. Oral tecovirimat for the treatment of smallpox. N Engl J Med 2018; 379(1): 44-53.
[http://dx.doi.org/10.1056/NEJMoa1705688] [PMID: 29972742]
[58]
Russo AT, Berhanu A, Bigger CB, et al. Co-administration of tecovirimat and ACAM2000™ in non-human primates: Effect of tecovirimat treatment on ACAM2000 immunogenicity and efficacy versus lethal monkeypox virus challenge. Vaccine 2020; 38(3): 644-54.
[http://dx.doi.org/10.1016/j.vaccine.2019.10.049] [PMID: 31677948]
[59]
Correction to Lancet Infect Dis. Outcomes of flucytosine-containing combination treatment for cryptococcal meningitis in a South African national access programme: A cross-sectional observational study. Lancet Infect Dis 2022; 22(9): 1365-73.
[http://dx.doi.org/10.1016/S1473-3099(22)00234-1]
[60]
Siegrist E, Sassine J. Antivirals with activity against monkeypox: A clinically oriented review. Clin Infect Dis 2022; 76(1): 155-64.
[PMID: 35904001]
[61]
Dounias E, Ichikawa M. Seasonal bushmeat hunger in the congo basin. EcoHealth 2017; 14(3): 575-90.
[http://dx.doi.org/10.1007/s10393-017-1252-y] [PMID: 28707044]
[62]
Bidaisee S, Macpherson CN. Zoonoses and one health: A review of the literature. J Parasitol Res 2014; 2014: 874345.
[http://dx.doi.org/10.1155/2014/874345]
[63]
Di Gennaro F, Veronese N, Marotta C, et al. Human monkeypox: A comprehensive narrative review and analysis of the public health implications. Microorganisms 2022; 10(8): 1633.
[http://dx.doi.org/10.3390/microorganisms10081633] [PMID: 36014051]

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