Abstract
Osteosarcoma is the most common primary bone malignancy and has a high tendency of local invasion. Although a lot of studies have focused on chemotherapy and combination chemotherapy regimens in recent years, still, there is no particularly perfect regimen for the treatment of relapsed or metastatic OS, and the prognosis is still relatively poor. As a new therapeutic method, targeted therapy provides a new scheme for patients with osteosarcoma and has a wide application prospect. This article reviews the latest progress of targeted therapy for osteosarcoma, and summarizes the research on the corresponding targets of osteosarcoma through six major pathways. These studies can pave the way for new treatments for osteosarcoma patients who need them.
[http://dx.doi.org/10.3322/caac.21442] [PMID: 29313949]
[http://dx.doi.org/10.2174/157488708785700267] [PMID: 18782081]
[http://dx.doi.org/10.1093/annonc/mdq276] [PMID: 20943636]
[http://dx.doi.org/10.1016/S0959-8049(02)00037-0] [PMID: 12044509]
[http://dx.doi.org/10.1016/j.epsc.2017.09.022] [PMID: 29085778]
[http://dx.doi.org/10.1002/pbc.27227] [PMID: 29923370]
[http://dx.doi.org/10.1016/j.canlet.2020.12.024] [PMID: 33359211]
[http://dx.doi.org/10.1002/cncr.21369] [PMID: 16155943]
[http://dx.doi.org/10.3390/cells10051240] [PMID: 34069999]
[http://dx.doi.org/10.1093/annonc/mdu256] [PMID: 25210081]
[http://dx.doi.org/10.1093/annonc/mdu526] [PMID: 25421877]
[http://dx.doi.org/10.1042/BST20191055] [PMID: 32311020]
[PMID: 30695681]
[http://dx.doi.org/10.21873/anticanres.12661] [PMID: 29848743]
[http://dx.doi.org/10.1111/cpr.13102] [PMID: 34309110]
[http://dx.doi.org/10.1016/j.phrs.2021.105684] [PMID: 34022396]
[http://dx.doi.org/10.1038/s41571-021-00519-8] [PMID: 34131316]
[http://dx.doi.org/10.1002/jor.24659] [PMID: 32162720]
[http://dx.doi.org/10.1016/j.jmoldx.2010.11.020] [PMID: 21458381]
[http://dx.doi.org/10.3390/ijms21083018] [PMID: 32344731]
[http://dx.doi.org/10.1038/onc.2012.387] [PMID: 22945645]
[http://dx.doi.org/10.1158/0008-5472.CAN-17-1240] [PMID: 28760857]
[http://dx.doi.org/10.1073/pnas.96.8.4325] [PMID: 10200261]
[http://dx.doi.org/10.18632/aging.100140] [PMID: 20445224]
[http://dx.doi.org/10.1038/ncb2004]
[http://dx.doi.org/10.18632/oncotarget.4857] [PMID: 26219338]
[http://dx.doi.org/10.1038/s41419-022-04800-1] [PMID: 35428764]
[http://dx.doi.org/10.1007/s11356-020-11466-9] [PMID: 33222070]
[http://dx.doi.org/10.1038/s41598-018-24075-x] [PMID: 29636527]
[http://dx.doi.org/10.1158/1078-0432.CCR-09-2151] [PMID: 20028770]
[http://dx.doi.org/10.1158/0008-5472.CAN-05-1276] [PMID: 16230394]
[http://dx.doi.org/10.1371/journal.pone.0166233] [PMID: 27898692]
[http://dx.doi.org/10.1158/1535-7163.MCT-11-0167] [PMID: 21490307]
[http://dx.doi.org/10.1158/2159-8290.CD-17-1152] [PMID: 30266815]
[http://dx.doi.org/10.1002/ijc.22820] [PMID: 17520676]
[http://dx.doi.org/10.1016/j.ctrv.2021.102154] [PMID: 33524794]
[http://dx.doi.org/10.7150/ijbs.10190] [PMID: 25332683]
[http://dx.doi.org/10.1016/0092-8674(93)90663-B] [PMID: 8425220]
[http://dx.doi.org/10.1002/j.1460-2075.1993.tb06202.x] [PMID: 8262051]
[http://dx.doi.org/10.1177/1758835920922055] [PMID: 32426053]
[http://dx.doi.org/10.3727/096504012X13522227232237] [PMID: 23461061]
[http://dx.doi.org/10.1038/nrg3293] [PMID: 22986266]
[http://dx.doi.org/10.1016/j.cell.2010.03.030] [PMID: 20434984]
[http://dx.doi.org/10.1371/journal.pone.0087003] [PMID: 24466310]
[http://dx.doi.org/10.1038/s41419-019-2022-2] [PMID: 31653826]
[http://dx.doi.org/10.1038/s41413-018-0009-8] [PMID: 29644114]
[PMID: 32922477]
[http://dx.doi.org/10.1080/15384047.2019.1680061] [PMID: 31651209]
[http://dx.doi.org/10.1016/j.phymed.2020.153183] [PMID: 32113150]
[http://dx.doi.org/10.3892/mmr.2020.11000] [PMID: 32323765]
[http://dx.doi.org/10.18632/oncotarget.20987] [PMID: 29156780]
[http://dx.doi.org/10.1177/1534735419890917] [PMID: 31855073]
[http://dx.doi.org/10.1080/15384101.2019.1676087] [PMID: 31601147]
[http://dx.doi.org/10.1016/j.canlet.2020.10.008] [PMID: 33038488]
[http://dx.doi.org/10.1186/s12943-020-01269-4] [PMID: 33106166]
[http://dx.doi.org/10.2174/1871530320666200821155756] [PMID: 32955002]
[http://dx.doi.org/10.1016/S0140-6736(20)30165-3] [PMID: 32145796]
[http://dx.doi.org/10.1016/j.bbadis.2018.02.004] [PMID: 29452249]
[http://dx.doi.org/10.21873/anticanres.15406] [PMID: 34848441]
[http://dx.doi.org/10.21873/anticanres.13565] [PMID: 31366491]
[http://dx.doi.org/10.1007/s00280-021-04363-6] [PMID: 34655298]
[http://dx.doi.org/10.1158/1078-0432.CCR-18-1256] [PMID: 30131386]
[http://dx.doi.org/10.1158/1078-0432.CCR-18-0372] [PMID: 30397176]
[http://dx.doi.org/10.1016/j.annonc.2021.09.015] [PMID: 34656740]
[http://dx.doi.org/10.1016/S1470-2045(21)00034-6] [PMID: 33794206]
[http://dx.doi.org/10.1016/j.ccr.2011.10.001] [PMID: 22094256]
[http://dx.doi.org/10.1111/cas.13765] [PMID: 30099814]
[http://dx.doi.org/10.1002/jcp.28026] [PMID: 30624782]
[http://dx.doi.org/10.23736/S0391-1977.19.03108-0] [PMID: 31797655]
[http://dx.doi.org/10.3892/or.2020.7632] [PMID: 32627005]
[http://dx.doi.org/10.2147/OTT.S165647] [PMID: 30774369]
[http://dx.doi.org/10.1158/0008-5472.CAN-06-1576] [PMID: 17018632]
[http://dx.doi.org/10.1016/j.cell.2017.03.035] [PMID: 28388417]
[http://dx.doi.org/10.1016/j.trecan.2017.04.002] [PMID: 28718419]
[http://dx.doi.org/10.1016/j.tibs.2011.03.006] [PMID: 21531565]
[http://dx.doi.org/10.1016/j.semcancer.2021.06.019] [PMID: 34175443]
[http://dx.doi.org/10.1016/j.cca.2014.12.041] [PMID: 25704303]
[http://dx.doi.org/10.2174/092986710793361234] [PMID: 20939811]
[http://dx.doi.org/10.1007/s00280-012-2043-3] [PMID: 23377372]
[http://dx.doi.org/10.1016/j.ijsu.2015.04.050] [PMID: 25936826]
[http://dx.doi.org/10.1177/1533034615609014] [PMID: 26443801]
[http://dx.doi.org/10.1016/j.sjbs.2021.05.006] [PMID: 34220214]
[http://dx.doi.org/10.3892/or.2018.6346] [PMID: 29620278]
[http://dx.doi.org/10.3892/mmr.2021.12569] [PMID: 34913077]
[http://dx.doi.org/10.1042/BSR20181501] [PMID: 30442873]
[PMID: 25792811]
[http://dx.doi.org/10.1080/15384047.2015.1017155] [PMID: 25869769]
[http://dx.doi.org/10.1158/1535-7163.MCT-14-0711] [PMID: 25519700]
[http://dx.doi.org/10.1016/S1470-2045(14)71136-2] [PMID: 25498219]
[http://dx.doi.org/10.1002/pbc.25334] [PMID: 25446280]
[http://dx.doi.org/10.2147/CMAR.S238173] [PMID: 32368141]
[http://dx.doi.org/10.12659/MSM.910201] [PMID: 30182951]
[http://dx.doi.org/10.1016/j.pharep.2017.04.007] [PMID: 28623712]
[http://dx.doi.org/10.1016/j.jbo.2022.100415] [PMID: 35573641]
[http://dx.doi.org/10.1042/BSR20160165] [PMID: 27653525]
[http://dx.doi.org/10.1016/j.ejphar.2019.172477] [PMID: 31228450]
[http://dx.doi.org/10.1016/j.sjbs.2021.07.019] [PMID: 34466065]
[http://dx.doi.org/10.3390/molecules24142665] [PMID: 31340526]
[http://dx.doi.org/10.1248/bpb.b21-00991] [PMID: 35431285]
[http://dx.doi.org/10.1155/2018/4306579] [PMID: 29750154]
[http://dx.doi.org/10.1186/s13020-021-00520-4] [PMID: 34819120]
[http://dx.doi.org/10.1002/jbt.22597] [PMID: 32762018]
[http://dx.doi.org/10.1016/j.jpba.2021.114088] [PMID: 33957363]
[http://dx.doi.org/10.1155/2022/3983637] [PMID: 35310040]
[http://dx.doi.org/10.1159/000485536] [PMID: 29197865]
[http://dx.doi.org/10.1111/cpr.12093] [PMID: 24517182]
[http://dx.doi.org/10.1155/2021/2895893] [PMID: 34950224]
[http://dx.doi.org/10.2147/OTT.S274451] [PMID: 33235467]
[http://dx.doi.org/10.1002/ijc.28933] [PMID: 24771207]
[http://dx.doi.org/10.3892/or.2016.4922] [PMID: 27430283]
[http://dx.doi.org/10.3892/ijo.2021.5229] [PMID: 34080667]
[http://dx.doi.org/10.1016/j.canlet.2022.215660] [PMID: 35318116]
[http://dx.doi.org/10.1083/jcb.153.4.865] [PMID: 11352945]
[PMID: 12234980]
[http://dx.doi.org/10.1002/mc.22993] [PMID: 30790360]
[PMID: 31122179]
[http://dx.doi.org/10.1016/j.ejmech.2020.112589] [PMID: 32717530]
[http://dx.doi.org/10.1038/bjc.2013.643] [PMID: 24129234]
[http://dx.doi.org/10.1038/s41416-018-0020-2] [PMID: 29551775]
[http://dx.doi.org/10.3390/molecules28083385] [PMID: 37110619]
[http://dx.doi.org/10.1080/13543776.2021.1890027] [PMID: 33573401]
[http://dx.doi.org/10.18632/aging.102423] [PMID: 31719210]
[http://dx.doi.org/10.1016/j.ctarc.2022.100617] [PMID: 36027697]
[http://dx.doi.org/10.1093/abbs/gmt002] [PMID: 23403511]
[http://dx.doi.org/10.1021/ml500394m] [PMID: 25589937]
[http://dx.doi.org/10.1016/S1470-2045(21)00387-9] [PMID: 34416158]
[http://dx.doi.org/10.1016/j.lfs.2020.118011] [PMID: 32592723]
[http://dx.doi.org/10.1038/cddis.2016.421] [PMID: 28406476]
[http://dx.doi.org/10.18632/oncotarget.17142] [PMID: 28465477]
[http://dx.doi.org/10.18632/oncotarget.6708] [PMID: 26713602]
[http://dx.doi.org/10.1111/febs.14416] [PMID: 29474747]
[http://dx.doi.org/10.2174/1871520620666200402074752] [PMID: 32238141]
[PMID: 33015767]
[http://dx.doi.org/10.3233/CBM-170906] [PMID: 30223385]
[http://dx.doi.org/10.1155/2016/7068986] [PMID: 27777493]
[http://dx.doi.org/10.1159/000430172] [PMID: 26202364]
[http://dx.doi.org/10.3389/fonc.2022.884559] [PMID: 35651811]
[PMID: 26396534]
[http://dx.doi.org/10.1371/journal.pone.0190086] [PMID: 29293555]
[http://dx.doi.org/10.3390/ijms23020705] [PMID: 35054891]
[PMID: 29257309]
[PMID: 26045903]
[http://dx.doi.org/10.18632/oncotarget.27115] [PMID: 31448053]
[http://dx.doi.org/10.1007/s10147-015-0848-x] [PMID: 26077139]
[http://dx.doi.org/10.1002/pbc.22479] [PMID: 20486173]
[http://dx.doi.org/10.1158/0008-5472.CAN-09-1693] [PMID: 19789339]
[http://dx.doi.org/10.1002/pbc.23157] [PMID: 21630428]
[http://dx.doi.org/10.1158/1078-0432.CCR-12-2293] [PMID: 23434734]
[http://dx.doi.org/10.1016/j.jot.2019.07.003] [PMID: 32440509]
[http://dx.doi.org/10.1002/ijc.29269] [PMID: 25307878]
[http://dx.doi.org/10.1111/cas.12686] [PMID: 25940371]
[http://dx.doi.org/10.1186/s13045-016-0313-y] [PMID: 27590878]
[http://dx.doi.org/10.1002/ijc.32180] [PMID: 30719715]
[PMID: 26328246]
[http://dx.doi.org/10.1016/S1470-2045(19)30825-3] [PMID: 32078813]
[http://dx.doi.org/10.1038/s41598-018-22469-5] [PMID: 29520051]
[http://dx.doi.org/10.18632/genesandcancer.91] [PMID: 26807203]
[http://dx.doi.org/10.1158/1078-0432.CCR-17-0754] [PMID: 28533223]
[http://dx.doi.org/10.1021/jm401753e] [PMID: 24456472]
[http://dx.doi.org/10.1038/sj.onc.1207198] [PMID: 14614447]
[http://dx.doi.org/10.1016/j.molonc.2008.02.004] [PMID: 19383329]
[http://dx.doi.org/10.1038/sj.onc.1208419] [PMID: 15735745]
[http://dx.doi.org/10.1093/abbs/gms053] [PMID: 22843172]
[http://dx.doi.org/10.1158/0008-5472.CAN-12-2807] [PMID: 23400593]
[http://dx.doi.org/10.1158/1078-0432.CCR-07-5113] [PMID: 18927278]
[http://dx.doi.org/10.1186/s11658-022-00320-0] [PMID: 35236304]
[http://dx.doi.org/10.3390/jcm8060900] [PMID: 31238539]
[http://dx.doi.org/10.1186/1476-4598-8-118] [PMID: 20003259]